Op de reukbol gericht QD-bioconjugaat en Kv1.3-blokkerende peptide verbeteren de metabole gezondheid bij zwaarlijvige mannelijke muizen

Het reuksysteem is een aanjager van het voedingsgedrag, waarbij de reukscherpte wordt gemoduleerd door de metabolische toestand van het individu. De prikkelbaarheid van de belangrijkste outputneuronen van de bulbus olfactorius (OB) kan worden gemoduleerd door zich te richten op een spanningsafhankelijk kaliumkanaal, Kv1.3, dat reageert op veranderingen in metabole factoren zoals insuline, glucose en glucagon-achtig peptide-1 .

Omdat is vastgesteld dat gengerichte deletie of remming van Kv1.3 in de periferie het energiemetabolisme verhoogt en het lichaamsgewicht verlaagt, veronderstelden we dat remming van Kv1.3 selectief in de OB de prikkelbaarheid van de outputneuronen zou kunnen verbeteren om veranderingen in energie op te roepen. homeostase. We hebben daarbij metaal-histidine-coördinatie gebruikt om de Kv1.3-remmer margatoxine (MgTx) zelf te assembleren tot fluorescerende kwantumdots (QDMgTx) als een middel om cellen in vivo te labelen en veranderingen in neuronale prikkelbaarheid en metabolisme te testen wanneer ze aan de OB worden afgeleverd.

Gebruik patch-clamp elektrofysiologie te Kv1.3 eigenschappen meten heteroloog tot expressie cellen en natieve mitrale cellen OB plakken, vonden we dat QDMgTx hadden een hoge snelheid van remming, maar met een lagere IC _50,  en verhoogde actiepotentiaal spuitfrequentie. QDMgTx was in staat om gekloonde Kv1.3-kanalen te labelen, maar was niet zichtbaar bij levering aan native Kv1.3 in de OB. Door voeding geïnduceerde zwaarlijvige muizen bleken het lichaamsgewicht te verminderen en glucose sneller te verwijderen na osmotische minipompafgifte van QDMgTx/MgTx aan de verloskundige, en na toediening van MgTx verhoogden ze het gebruik van vetten als brandstof (verminderde respiratoire uitwisselingsratio). Deze resultaten suggereren dat een verbeterde prikkelbaarheid van bulbaire output-neuronen metabolische reacties kan aansturen.

Verbeterde veiligheid en anti-tumor werkzaamheid van schakelbare dubbele chimere antigeenreceptor-engineered T-cel tegen solide tumor door middel van een synthetisch bifunctioneel PD-L1-blokkerend peptide

Door chimere antigeenreceptor (CAR) ontwikkelde T-cellen (CAR-Ts)-therapie heeft een uitstekende werkzaamheid bij de behandeling van kanker, met name de indrukwekkende resultaten bij hematologische maligniteiten. Helaas wordt de toepassing ervan op solide tumoren uitgedaagd door de off-target effecten veroorzaakt door het ontbreken van tumorspecifieke antigenen en de immunosuppressie veroorzaakt door de micro-omgeving van de tumor.

We construeerden een schakelbare dubbele receptor CAR-T-cel (sdCAR-T) waarvan de activiteit was gebaseerd op dubbele antigenen (mesotheline en fluoresceïne-isothiocyanaat) en strikt werd gecontroleerd door een “switch” (FPBM) bestaande uit een PD-L1-blokkerend peptide geconjugeerd aan fluoresceïne isothiocyanaat. SdCAR-T-cellen werden alleen geactiveerd wanneer FPBM en verwante tumorcellen die zowel PD-L1 als mesotheline tot expressie brengen, naast elkaar bestaan. Belangrijk is dat langdurige proliferatie-experimenten in vitro en farmacodynamisch onderzoek in vivo een sterkere antitumoractiviteit van dit systeem aantoonden in vergelijking met de tweede generatie mesotheline CAR-T-cellen. Aangezien dit nieuwe behandelingsparadigma veiliger en effectiever was dan traditionele CAR-T-cellen, kan het een nieuwe strategie worden voor de behandeling van solide tumoren.

 

Gerichte blokkering van TGF-β-receptor I-bindingsplaats met behulp van op maat gemaakte peptidesegmenten om de signaalroute te remmen

Achtergrond:  TGF-β-isovormen spelen een cruciale rol in diverse cellulaire processen. Daarom biedt het targeten en remmen van de TGF-β-signaleringsroute een potentiële therapeutische mogelijkheid. TGF-β-isovormen binden en brengen de receptoren (TβRII en TβRI) op een geordende manier samen om een ​​signaalcomplex te vormen.

Doelstellingen:  Hierin is een antagonistische variant van TGF-β (AnTβ) ontworpen en bereid om de vorming van een signaalcomplex en bijgevolg de signaalroute ervan te remmen. Deze TGF-β homodimere variant bevat intacte TβRII-bindingsplaatsen en geblokkeerde TβRI-bindingsplaatsen door drie peptidesegmenten te vervangen. Dus AnTβ kon alleen binden aan TβRII, maar binding en rekrutering van TβRI voorkomen om een ​​signaleringscomplex te vormen.

Materialen en methoden:  Een betrouwbaar model van AnTβ werd gebouwd en verfijnd met behulp van moleculaire dynamica (MD) simulatie, gevolgd door het onderzoeken van de interacties van AnTβ met de receptoren met behulp van in silico docking-onderzoeken. Na expressie van disulfide-gebonden AnTβ in een SHuffle-stam en zuivering van het eiwit met behulp van affiniteitschromatografie, werd de biologische activiteit ervan geëvalueerd met behulp van Mink-longepitheelcellen (Mvl Lu).

Resultaten:  Er werden geen significante significante veranderingen in de AnTβ-structuur waargenomen in vergelijking met het natieve eiwit. Op basis van de koppelingsanalyse bindt AnTβ aan TβRII vergelijkbaar met TGF-β en de binding aan TRI was aanzienlijk verminderd, wat consistent was met ons ontwerpdoel. Op cellen gebaseerde bioassay gaf aan dat AnTβ door TGF-β geïnduceerde remming van celgroei zou kunnen moduleren.

Conclusies:  Onze analyse suggereert dat de antagonistische potentie van AnTβ kan worden gebruikt als een anti-TGFβ-signaleringsfactor in de toekomstperspectieven.

Van erwt afgeleide peptiden, VLP, LLP, VA en LL, verbeteren de insulineresistentie in HepG2-cellen door IRS-1/PI3K/AKT te activeren en ROS-gemedieerde p38MAPK-signalering te blokkeren

Deze studie evalueerde het effect van vier peptiden, VLP, LLP, LL en LL van erwt op het reguleren van glucosemetabolisme en antioxidant via IRS-1/PI3K/AKT en p38MAPK-signaalroute in IR-HepG2- cellen geïnduceerd door ^10-6  M insuline. De genenexpressie van PEPCK, G6Pase, GLUT2 en IRS-1 en eiwitten van IRS-1, p(Ser307)-IRS-1, AKT, p(Ser473)-AKT, p38MAPK en p-p38MAPK werden bepaald door RT- PCR en western blotting, respectievelijk.

De resultaten laten zien dat ze zeer krachtig zijn op het stimuleren van het glucosemetabolisme en het verlichten van oxidatieve stress in IR-HepG2-cellen. VLP, LLP, VA en LL verminderden Ser307- fosforylering van IRS-1 en bevorderden Ser473-fosforylering van AKT. Onder hen verhoogden LLP, VA en LL de expressie van zowel het gen als het eiwit van GLUT2, en VLP en LL verminderden p38MAPK-fosforylering en vertoonden een sterke antioxidantcapaciteit.

Daarom hebben erwten-oligopeptiden een aanzienlijk potentieel voor het omkeren van de metabole afwijkingen die gepaard gaan met type 2-diabetes. PRAKTISCHE TOEPASSINGEN: Dit artikel onderzocht het interventie-effect van VLP, LLP, VA en LL dat van erwt op insulineresistentie, en de mechanismen werden gedetecteerd door western blotting. De resultaten bieden theoretische kennis voor de preventie van insulineresistentie in T2D van erwt-afgeleide peptiden en leggen de basis voor de ontwikkeling van functionele producten en medicijnen in de toekomst.

Blokkering van de PD-1/PD-L1-interactie door een nieuwe cyclische peptideremmer voor kankerimmunotherapie

Door de interactie van PD-1/PD-L1 kunnen tumorcellen ontsnappen aan immuunsurveillance. Klinisch succes van de antilichaamgeneesmiddelen heeft bewezen dat blokkade van de PD-1/PD-L1-route een veelbelovende strategie is voor immunotherapie tegen kanker. Hier hebben we een cyclisch peptide C8 ontwikkeld met behulp van Ph.D.-C7C-faagweergavetechnologie.

C8 vertoonde een hoge bindingsaffiniteit met hPD-1 en zou de interactie van PD-1/PD-L1 effectief kunnen verstoren. Verder zou C8  de activering van CD8 ⁺ -T-cellen in mononucleaire cellen van menselijk perifeer bloed (PBMC’s) kunnen stimuleren . We hebben ook waargenomen dat C8 tumorgroei in CT26 en B16-OVA kon onderdrukken , evenals anti-PD-1 antilichaam-resistent B16-muismodel. De infiltratie van CD8 T-cellen nam significant toe in de micro-omgeving van de tumor, en de IFN-γ-secretie door CD8 ⁺  T-cellen in drainerende lymfeklieren nam ook toe.

Tegelijkertijd maakten we gebruik van modellen voor uitputting van T-cellen en bevestigden we dat C8 anti-tumor effecten uitoefende via het activeren van CD8 ⁺  T-cellen afhankelijke wijze. Het interactiemodel van C8 met hPD-1 werd gesimuleerd en bevestigd door alanine-scanning. Concluderend, C8 vertoont antitumorvermogen door blokkering van PD-1/PD-L1-interactie, en C8 kan een alternatieve kandidaat zijn voor kankerimmunotherapie.

Human Visfatin(Visfatin)ELISA Kit
YLA0808HU-48T	Shanghai YL Biotech	48T	EUR 435

Human Visfatin(Visfatin)ELISA Kit
YLA0808HU-96T	Shanghai YL Biotech	96T	EUR 562.5

(NVDP)4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide
NVDP41-P	Alpha Diagnostics	100 ug	EUR 196.8

Influenza A virus (H5N1) matrix protein 2 hybrid sequence Control/blocking peptide
M2E11-P	Alpha Diagnostics	100 ug	EUR 196.8

(DRAAGQPAG)3 (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) control/blocking peptide
DRAA31-P	Alpha Diagnostics	100 ug	EUR 196.8

C-Peptide Blocking Peptide
3277BP-50	Biovision	each	EUR 183.6

Visfatin antibody
70R-12451	Fitzgerald	100 ug	EUR 483.6
Description: Rabbit polyclonal Visfatin antibody

Visfatin antibody
70R-12452	Fitzgerald	100 ug	EUR 552
Description: Rabbit polyclonal Visfatin antibody

Visfatin antibody
70R-12453	Fitzgerald	100 ug	EUR 483.6
Description: Rabbit polyclonal Visfatin antibody

Visfatin protein
30R-2761	Fitzgerald	10 ug	EUR 224.4
Description: Purified recombinant Human Visfatin protein

Visfatin protein
30R-2762	Fitzgerald	10 ug	EUR 268.8
Description: Purified recombinant Human Visfatin protein

Visfatin protein
30R-2763	Fitzgerald	10 ug	EUR 337.2
Description: Purified recombinant Human Visfatin protein

Visfatin protein
30R-AV022	Fitzgerald	25 ug	EUR 327.6
Description: Purified recombinant Human Visfatin protein

Visfatin antibody
10R-1077	Fitzgerald	100 ul	EUR 418.8
Description: Mouse monoclonal Visfatin antibody

Visfatin antibody
20R-1861	Fitzgerald	100 ug	EUR 807.6
Description: Rabbit polyclonal Visfatin antibody

Visfatin antibody
20R-1862	Fitzgerald	100 ug	EUR 807.6
Description: Rabbit polyclonal Visfatin antibody

Visfatin antibody
20R-1863	Fitzgerald	100 ug	EUR 807.6
Description: Rabbit polyclonal Visfatin antibody

Visfatin Protein
20-abx261744	Abbexa	EUR 4318.80 EUR 393.60 EUR 276.00	1 mg 25 ug 5 ug

Visfatin Protein
20-abx262039	Abbexa	EUR 5388.00 EUR 393.60 EUR 276.00	1 mg 25 ug 5 ug

Visfatin Protein
20-abx262171	Abbexa	EUR 6674.40 EUR 393.60 EUR 276.00	1 mg 25 ug 5 ug

rHu Visfatin
AK9981-0005	Akron Biotech	5µg	Ask for price

rHu Visfatin
AK9981-0025	Akron Biotech	25µg	Ask for price

rHu Visfatin
AK9981-0100	Akron Biotech	100µg	Ask for price

rHu Visfatin
AK9981-1000	Akron Biotech	1mg	Ask for price

Visfatin antibody
PAab09847	Lifescience Market	100 ug	EUR 463.2

Visfatin Antibody
5907R-100	Biovision	each	EUR 379.2

Visfatin Antibody
5907R-30T	Biovision	each	EUR 175.2

Visfatin Antibody
5908-100	Biovision	each	EUR 424.8

Visfatin Antibody
5908-30T	Biovision	each	EUR 175.2

Visfatin Antibody
5909-100	Biovision	each	EUR 379.2

Visfatin Antibody
5909-30T	Biovision	each	EUR 175.2

Hsp70 Blocking Peptide
33R-10632	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Hsp70 antibody, catalog no. 70R-11611

SIRT7 Blocking Peptide
33R-10633	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIRT7 antibody, catalog no. 70R-11612

MAPKAPK2 Blocking Peptide
33R-10634	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MAPKAPK2 antibody, catalog no. 70R-11613

CD339 Blocking Peptide
33R-10635	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CD339 antibody, catalog no. 70R-11614

PKA Blocking Peptide
33R-10637	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PKA antibody, catalog no. 70R-11621

Raf1 Blocking Peptide
33R-10638	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Raf1 antibody, catalog no. 70R-11622

Wee1 Blocking Peptide
33R-10639	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Wee1 antibody, catalog no. 70R-11626

IHH Blocking Peptide
33R-1064	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SLC26A1 antibody, catalog no. 70R-6562

GSTP1 Blocking Peptide
33R-10640	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GSTP1 antibody, catalog no. 70R-11628

TNFR1 Blocking Peptide
33R-10641	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TNFR1 antibody, catalog no. 70R-11629

LSD1 Blocking Peptide
33R-10642	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LSD1 antibody, catalog no. 70R-11631

STAT1 Blocking Peptide
33R-10643	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of STAT1 antibody, catalog no. 70R-11633

MAK10 Blocking Peptide
33R-10644	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MAK10 antibody, catalog no. 70R-11634

ACADM Blocking Peptide
33R-10647	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADM antibody, catalog no. 70R-11637

ACADL Blocking Peptide
33R-10649	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADL antibody, catalog no. 70R-11639

SLC26A1 Blocking Peptide
33R-1065	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CACNB2 antibody, catalog no. 70R-1508

ACADSB Blocking Peptide
33R-10650	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADSB antibody, catalog no. 70R-11649

ACADSB Blocking Peptide
33R-10651	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADSB antibody, catalog no. 70R-11656

Survivin Blocking Peptide
33R-10653	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Survivin antibody, catalog no. 70R-11659

Bid Blocking Peptide
33R-10654	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bid antibody, catalog no. 70R-11670

CD40L Blocking Peptide
33R-10655	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CD40L antibody, catalog no. 70R-11674

cIAP1 Blocking Peptide
33R-10656	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of cIAP1 antibody, catalog no. 70R-11676

cIAP1 Blocking Peptide
33R-10657	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of cIAP1 antibody, catalog no. 70R-11675

cIAP2 Blocking Peptide
33R-10658	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of cIAP2 antibody, catalog no. 70R-11677

XIAP Blocking Peptide
33R-10659	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XIAP antibody, catalog no. 70R-11678

CACNB2 Blocking Peptide
33R-1066	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LHPP antibody, catalog no. 70R-4027

Perforin Blocking Peptide
33R-10660	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Perforin antibody, catalog no. 70R-11680

NIK Blocking Peptide
33R-10665	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NIK antibody, catalog no. 70R-11685

TrkA Blocking Peptide
33R-10666	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TrkA antibody, catalog no. 70R-11686

AIF Blocking Peptide
33R-10667	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AIF antibody, catalog no. 70R-11690

DR6 Blocking Peptide
33R-10668	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DR6 antibody, catalog no. 70R-11695

SIRT3 Blocking Peptide
33R-10669	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIRT3 antibody, catalog no. 70R-11698

LHPP Blocking Peptide
33R-1067	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of UPP1 antibody, catalog no. 70R-3171

SIRT4 Blocking Peptide
33R-10670	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIRT4 antibody, catalog no. 70R-11699

SIRT5 Blocking Peptide
33R-10671	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIRT5 antibody, catalog no. 70R-11700

NAIP Blocking Peptide
33R-10672	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NAIP antibody, catalog no. 70R-11701

MBD2a Blocking Peptide
33R-10673	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MBD2a antibody, catalog no. 70R-11702

SALL1 Blocking Peptide
33R-10674	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SALL1 antibody, catalog no. 70R-11703

SIAH3 Blocking Peptide
33R-10675	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIAH3 antibody, catalog no. 70R-11704

ACAD9 Blocking Peptide
33R-10676	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACAD9 antibody, catalog no. 70R-11705

ACADVL Blocking Peptide
33R-10677	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADVL antibody, catalog no. 70R-11706

TRIM71 Blocking Peptide
33R-10678	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TRIM71 antibody, catalog no. 70R-11707

EZH2 Blocking Peptide
33R-10679	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EZH2 antibody, catalog no. 70R-11708

UPP1 Blocking Peptide
33R-1068	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PVRIG antibody, catalog no. 70R-6255

MyD88 Blocking Peptide
33R-10680	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MyD88 antibody, catalog no. 70R-11710

ACAT1 Blocking Peptide
33R-10681	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACAT1 antibody, catalog no. 70R-11711

ABAD Blocking Peptide
33R-10682	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ABAD antibody, catalog no. 70R-11712

PKB Blocking Peptide
33R-10683	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PKB antibody, catalog no. 70R-11713

GAI2 Blocking Peptide
33R-10684	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GAI2 antibody, catalog no. 70R-11715

GABP Blocking Peptide
33R-10685	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GABP antibody, catalog no. 70R-11716

TLR4 Blocking Peptide
33R-10686	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TLR4 antibody, catalog no. 70R-11719

ACAT2 Blocking Peptide
33R-10687	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACAT2 antibody, catalog no. 70R-11720

ERAB Blocking Peptide
33R-10688	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ERAB antibody, catalog no. 70R-11721

PVRIG Blocking Peptide
33R-1069	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EXOSC10 antibody, catalog no. 70R-4673

PARD3 Blocking Peptide
33R-10691	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PARD3 antibody, catalog no. 70R-11725

TCTN2 Blocking Peptide
33R-10692	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TCTN2 antibody, catalog no. 70R-11727

HADH Blocking Peptide
33R-10693	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HADH antibody, catalog no. 70R-11728

FATP4 Blocking Peptide
33R-10696	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FATP4 antibody, catalog no. 70R-11731

Bid Blocking Peptide
33R-10697	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bid antibody, catalog no. 70R-11734

JMJD1A Blocking Peptide
33R-10698	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of JMJD1A antibody, catalog no. 70R-11735

RIP Blocking Peptide
33R-10699	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RIP antibody, catalog no. 70R-11737

EXOSC10 Blocking Peptide
33R-1070	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MKRN2 antibody, catalog no. 70R-2131

MBD1 Blocking Peptide
33R-10700	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MBD1 antibody, catalog no. 70R-11739

VENTX Blocking Peptide
33R-10702	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of VENTX antibody, catalog no. 70R-11742

ASC Blocking Peptide
33R-10703	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ASC antibody, catalog no. 70R-11744

RIP3 Blocking Peptide
33R-10704	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RIP3 antibody, catalog no. 70R-11745

SMAC Blocking Peptide
33R-10705	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SMAC antibody, catalog no. 70R-11747

RasGAP Blocking Peptide
33R-10706	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RasGAP antibody, catalog no. 70R-11749

TCTN3 Blocking Peptide
33R-10708	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TCTN3 antibody, catalog no. 70R-11753

BMF Blocking Peptide
33R-10709	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BMF antibody, catalog no. 70R-11754

MKRN2 Blocking Peptide
33R-1071	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AMZ2 antibody, catalog no. 70R-9376

EndoG Blocking Peptide
33R-10710	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EndoG antibody, catalog no. 70R-11755

ILP2 Blocking Peptide
33R-10711	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ILP2 antibody, catalog no. 70R-11756

PUMA Blocking Peptide
33R-10712	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PUMA antibody, catalog no. 70R-11758

p53NIDP1 Blocking Peptide
33R-10713	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of p53NIDP1 antibody, catalog no. 70R-11759

POU2F1 Blocking Peptide
33R-10714	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of POU2F1 antibody, catalog no. 70R-11760

FasL Blocking Peptide
33R-10715	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FasL antibody, catalog no. 70R-11761

FAF1 Blocking Peptide
33R-10716	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FAF1 antibody, catalog no. 70R-11762

BI1 Blocking Peptide
33R-10717	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BI1 antibody, catalog no. 70R-11763

TANK Blocking Peptide
33R-10718	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TANK antibody, catalog no. 70R-11764

PCNA Blocking Peptide
33R-10719	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PCNA antibody, catalog no. 70R-11765

AMZ2 Blocking Peptide
33R-1072	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RNF32 antibody, catalog no. 70R-1166

ALK Blocking Peptide
33R-10723	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ALK antibody, catalog no. 70R-11769

CREB Blocking Peptide
33R-10725	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CREB antibody, catalog no. 70R-11772

COX1 Blocking Peptide
33R-10726	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of COX1 antibody, catalog no. 70R-11773

COX1 Blocking Peptide
33R-10727	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of COX1 antibody, catalog no. 70R-11774

BLCAM Blocking Peptide
33R-10728	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BLCAM antibody, catalog no. 70R-11775

BRCA1 Blocking Peptide
33R-10729	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BRCA1 antibody, catalog no. 70R-11776

RNF32 Blocking Peptide
33R-1073	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GOLGA7 antibody, catalog no. 70R-2903

Cadherin Blocking Peptide
33R-10730	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Cadherin antibody, catalog no. 70R-11777

TFPI Blocking Peptide
33R-10735	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TFPI antibody, catalog no. 70R-11785

Hsp90 Blocking Peptide
33R-10737	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Hsp90 antibody, catalog no. 70R-11793

Hsp105 Blocking Peptide
33R-10738	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Hsp105 antibody, catalog no. 70R-11794

HMOX1 Blocking Peptide
33R-10739	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HMOX1 antibody, catalog no. 70R-11795

GOLGA7 Blocking Peptide
33R-1074	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACSL5 antibody, catalog no. 70R-6556

HMOX2 Blocking Peptide
33R-10740	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HMOX2 antibody, catalog no. 70R-11796

HCAM Blocking Peptide
33R-10741	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HCAM antibody, catalog no. 70R-11797

BMX Blocking Peptide
33R-10742	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BMX antibody, catalog no. 70R-11799

BMX Blocking Peptide
33R-10743	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BMX antibody, catalog no. 70R-11800

A1 Blocking Peptide
33R-10744	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of A1 antibody, catalog no. 70R-11802

AFX Blocking Peptide
33R-10745	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AFX antibody, catalog no. 70R-11803

BCL3 Blocking Peptide
33R-10746	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BCL3 antibody, catalog no. 70R-11804

BCL6 Blocking Peptide
33R-10747	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BCL6 antibody, catalog no. 70R-11805

ACSL5 Blocking Peptide
33R-1075	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CCND1 antibody, catalog no. 70R-10480

CETP Blocking Peptide
33R-10750	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CETP antibody, catalog no. 70R-11808

CCR1 Blocking Peptide
33R-10751	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CCR1 antibody, catalog no. 70R-11809

CCR2 Blocking Peptide
33R-10752	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CCR2 antibody, catalog no. 70R-11810

CCR3 Blocking Peptide
33R-10753	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CCR3 antibody, catalog no. 70R-11811

CXCR5 Blocking Peptide
33R-10754	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CXCR5 antibody, catalog no. 70R-11812

GADD153 Blocking Peptide
33R-10755	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GADD153 antibody, catalog no. 70R-11813

ICAM1 Blocking Peptide
33R-10756	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ICAM1 antibody, catalog no. 70R-11814

ILK1 Blocking Peptide
33R-10757	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ILK1 antibody, catalog no. 70R-11815