Op de reukbol gericht QD-bioconjugaat en Kv1.3-blokkerende peptide verbeteren de metabole gezondheid bij zwaarlijvige mannelijke muizen
Het reuksysteem is een aanjager van het voedingsgedrag, waarbij de reukscherpte wordt gemoduleerd door de metabolische toestand van het individu. De prikkelbaarheid van de belangrijkste outputneuronen van de bulbus olfactorius (OB) kan worden gemoduleerd door zich te richten op een spanningsafhankelijk kaliumkanaal, Kv1.3, dat reageert op veranderingen in metabole factoren zoals insuline, glucose en glucagon-achtig peptide-1 .
Omdat is vastgesteld dat gengerichte deletie of remming van Kv1.3 in de periferie het energiemetabolisme verhoogt en het lichaamsgewicht verlaagt, veronderstelden we dat remming van Kv1.3 selectief in de OB de prikkelbaarheid van de outputneuronen zou kunnen verbeteren om veranderingen in energie op te roepen. homeostase. We hebben daarbij metaal-histidine-coördinatie gebruikt om de Kv1.3-remmer margatoxine (MgTx) zelf te assembleren tot fluorescerende kwantumdots (QDMgTx) als een middel om cellen in vivo te labelen en veranderingen in neuronale prikkelbaarheid en metabolisme te testen wanneer ze aan de OB worden afgeleverd.
Gebruik patch-clamp elektrofysiologie te Kv1.3 eigenschappen meten heteroloog tot expressie cellen en natieve mitrale cellen OB plakken, vonden we dat QDMgTx hadden een hoge snelheid van remming, maar met een lagere IC 50, en verhoogde actiepotentiaal spuitfrequentie. QDMgTx was in staat om gekloonde Kv1.3-kanalen te labelen, maar was niet zichtbaar bij levering aan native Kv1.3 in de OB. Door voeding geïnduceerde zwaarlijvige muizen bleken het lichaamsgewicht te verminderen en glucose sneller te verwijderen na osmotische minipompafgifte van QDMgTx/MgTx aan de verloskundige, en na toediening van MgTx verhoogden ze het gebruik van vetten als brandstof (verminderde respiratoire uitwisselingsratio). Deze resultaten suggereren dat een verbeterde prikkelbaarheid van bulbaire output-neuronen metabolische reacties kan aansturen.
Verbeterde veiligheid en anti-tumor werkzaamheid van schakelbare dubbele chimere antigeenreceptor-engineered T-cel tegen solide tumor door middel van een synthetisch bifunctioneel PD-L1-blokkerend peptide
Door chimere antigeenreceptor (CAR) ontwikkelde T-cellen (CAR-Ts)-therapie heeft een uitstekende werkzaamheid bij de behandeling van kanker, met name de indrukwekkende resultaten bij hematologische maligniteiten. Helaas wordt de toepassing ervan op solide tumoren uitgedaagd door de off-target effecten veroorzaakt door het ontbreken van tumorspecifieke antigenen en de immunosuppressie veroorzaakt door de micro-omgeving van de tumor.
We construeerden een schakelbare dubbele receptor CAR-T-cel (sdCAR-T) waarvan de activiteit was gebaseerd op dubbele antigenen (mesotheline en fluoresceïne-isothiocyanaat) en strikt werd gecontroleerd door een “switch” (FPBM) bestaande uit een PD-L1-blokkerend peptide geconjugeerd aan fluoresceïne isothiocyanaat. SdCAR-T-cellen werden alleen geactiveerd wanneer FPBM en verwante tumorcellen die zowel PD-L1 als mesotheline tot expressie brengen, naast elkaar bestaan. Belangrijk is dat langdurige proliferatie-experimenten in vitro en farmacodynamisch onderzoek in vivo een sterkere antitumoractiviteit van dit systeem aantoonden in vergelijking met de tweede generatie mesotheline CAR-T-cellen. Aangezien dit nieuwe behandelingsparadigma veiliger en effectiever was dan traditionele CAR-T-cellen, kan het een nieuwe strategie worden voor de behandeling van solide tumoren.

Gerichte blokkering van TGF-β-receptor I-bindingsplaats met behulp van op maat gemaakte peptidesegmenten om de signaalroute te remmen
Achtergrond: TGF-β-isovormen spelen een cruciale rol in diverse cellulaire processen. Daarom biedt het targeten en remmen van de TGF-β-signaleringsroute een potentiële therapeutische mogelijkheid. TGF-β-isovormen binden en brengen de receptoren (TβRII en TβRI) op een geordende manier samen om een signaalcomplex te vormen.
Doelstellingen: Hierin is een antagonistische variant van TGF-β (AnTβ) ontworpen en bereid om de vorming van een signaalcomplex en bijgevolg de signaalroute ervan te remmen. Deze TGF-β homodimere variant bevat intacte TβRII-bindingsplaatsen en geblokkeerde TβRI-bindingsplaatsen door drie peptidesegmenten te vervangen. Dus AnTβ kon alleen binden aan TβRII, maar binding en rekrutering van TβRI voorkomen om een signaleringscomplex te vormen.
Materialen en methoden: Een betrouwbaar model van AnTβ werd gebouwd en verfijnd met behulp van moleculaire dynamica (MD) simulatie, gevolgd door het onderzoeken van de interacties van AnTβ met de receptoren met behulp van in silico docking-onderzoeken. Na expressie van disulfide-gebonden AnTβ in een SHuffle-stam en zuivering van het eiwit met behulp van affiniteitschromatografie, werd de biologische activiteit ervan geëvalueerd met behulp van Mink-longepitheelcellen (Mvl Lu).
Resultaten: Er werden geen significante significante veranderingen in de AnTβ-structuur waargenomen in vergelijking met het natieve eiwit. Op basis van de koppelingsanalyse bindt AnTβ aan TβRII vergelijkbaar met TGF-β en de binding aan TRI was aanzienlijk verminderd, wat consistent was met ons ontwerpdoel. Op cellen gebaseerde bioassay gaf aan dat AnTβ door TGF-β geïnduceerde remming van celgroei zou kunnen moduleren.
Conclusies: Onze analyse suggereert dat de antagonistische potentie van AnTβ kan worden gebruikt als een anti-TGFβ-signaleringsfactor in de toekomstperspectieven.
Van erwt afgeleide peptiden, VLP, LLP, VA en LL, verbeteren de insulineresistentie in HepG2-cellen door IRS-1/PI3K/AKT te activeren en ROS-gemedieerde p38MAPK-signalering te blokkeren
Deze studie evalueerde het effect van vier peptiden, VLP, LLP, LL en LL van erwt op het reguleren van glucosemetabolisme en antioxidant via IRS-1/PI3K/AKT en p38MAPK-signaalroute in IR-HepG2- cellen geïnduceerd door 10-6 M insuline. De genenexpressie van PEPCK, G6Pase, GLUT2 en IRS-1 en eiwitten van IRS-1, p(Ser307)-IRS-1, AKT, p(Ser473)-AKT, p38MAPK en p-p38MAPK werden bepaald door RT- PCR en western blotting, respectievelijk.
De resultaten laten zien dat ze zeer krachtig zijn op het stimuleren van het glucosemetabolisme en het verlichten van oxidatieve stress in IR-HepG2-cellen. VLP, LLP, VA en LL verminderden Ser307- fosforylering van IRS-1 en bevorderden Ser473-fosforylering van AKT. Onder hen verhoogden LLP, VA en LL de expressie van zowel het gen als het eiwit van GLUT2, en VLP en LL verminderden p38MAPK-fosforylering en vertoonden een sterke antioxidantcapaciteit.
Daarom hebben erwten-oligopeptiden een aanzienlijk potentieel voor het omkeren van de metabole afwijkingen die gepaard gaan met type 2-diabetes. PRAKTISCHE TOEPASSINGEN: Dit artikel onderzocht het interventie-effect van VLP, LLP, VA en LL dat van erwt op insulineresistentie, en de mechanismen werden gedetecteerd door western blotting. De resultaten bieden theoretische kennis voor de preventie van insulineresistentie in T2D van erwt-afgeleide peptiden en leggen de basis voor de ontwikkeling van functionele producten en medicijnen in de toekomst.
Blokkering van de PD-1/PD-L1-interactie door een nieuwe cyclische peptideremmer voor kankerimmunotherapie
Door de interactie van PD-1/PD-L1 kunnen tumorcellen ontsnappen aan immuunsurveillance. Klinisch succes van de antilichaamgeneesmiddelen heeft bewezen dat blokkade van de PD-1/PD-L1-route een veelbelovende strategie is voor immunotherapie tegen kanker. Hier hebben we een cyclisch peptide C8 ontwikkeld met behulp van Ph.D.-C7C-faagweergavetechnologie.
C8 vertoonde een hoge bindingsaffiniteit met hPD-1 en zou de interactie van PD-1/PD-L1 effectief kunnen verstoren. Verder zou C8 de activering van CD8 + -T-cellen in mononucleaire cellen van menselijk perifeer bloed (PBMC’s) kunnen stimuleren . We hebben ook waargenomen dat C8 tumorgroei in CT26 en B16-OVA kon onderdrukken , evenals anti-PD-1 antilichaam-resistent B16-muismodel. De infiltratie van CD8 T-cellen nam significant toe in de micro-omgeving van de tumor, en de IFN-γ-secretie door CD8 + T-cellen in drainerende lymfeklieren nam ook toe.
Tegelijkertijd maakten we gebruik van modellen voor uitputting van T-cellen en bevestigden we dat C8 anti-tumor effecten uitoefende via het activeren van CD8 + T-cellen afhankelijke wijze. Het interactiemodel van C8 met hPD-1 werd gesimuleerd en bevestigd door alanine-scanning. Concluderend, C8 vertoont antitumorvermogen door blokkering van PD-1/PD-L1-interactie, en C8 kan een alternatieve kandidaat zijn voor kankerimmunotherapie.
Human Visfatin(Visfatin)ELISA Kit |
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YLA0808HU-48T | Shanghai YL Biotech | 48T | EUR 435 |
Human Visfatin(Visfatin)ELISA Kit |
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YLA0808HU-96T | Shanghai YL Biotech | 96T | EUR 562.5 |
(NVDP)4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide |
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NVDP41-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Influenza A virus (H5N1) matrix protein 2 hybrid sequence Control/blocking peptide |
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M2E11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
(DRAAGQPAG)3 (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) control/blocking peptide |
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DRAA31-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
C-Peptide Blocking Peptide |
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3277BP-50 | Biovision | each | EUR 183.6 |
Visfatin antibody |
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70R-12451 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal Visfatin antibody |
Visfatin antibody |
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70R-12452 | Fitzgerald | 100 ug | EUR 552 |
Description: Rabbit polyclonal Visfatin antibody |
Visfatin antibody |
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70R-12453 | Fitzgerald | 100 ug | EUR 483.6 |
Description: Rabbit polyclonal Visfatin antibody |
Visfatin protein |
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30R-2761 | Fitzgerald | 10 ug | EUR 224.4 |
Description: Purified recombinant Human Visfatin protein |
Visfatin protein |
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30R-2762 | Fitzgerald | 10 ug | EUR 268.8 |
Description: Purified recombinant Human Visfatin protein |
Visfatin protein |
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30R-2763 | Fitzgerald | 10 ug | EUR 337.2 |
Description: Purified recombinant Human Visfatin protein |
Visfatin protein |
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30R-AV022 | Fitzgerald | 25 ug | EUR 327.6 |
Description: Purified recombinant Human Visfatin protein |
Visfatin antibody |
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10R-1077 | Fitzgerald | 100 ul | EUR 418.8 |
Description: Mouse monoclonal Visfatin antibody |
Visfatin antibody |
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20R-1861 | Fitzgerald | 100 ug | EUR 807.6 |
Description: Rabbit polyclonal Visfatin antibody |
Visfatin antibody |
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20R-1862 | Fitzgerald | 100 ug | EUR 807.6 |
Description: Rabbit polyclonal Visfatin antibody |
Visfatin antibody |
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20R-1863 | Fitzgerald | 100 ug | EUR 807.6 |
Description: Rabbit polyclonal Visfatin antibody |
Visfatin Protein |
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20-abx261744 | Abbexa |
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Visfatin Protein |
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20-abx262039 | Abbexa |
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Visfatin Protein |
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20-abx262171 | Abbexa |
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rHu Visfatin |
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AK9981-0005 | Akron Biotech | 5µg | Ask for price |
rHu Visfatin |
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AK9981-0025 | Akron Biotech | 25µg | Ask for price |
rHu Visfatin |
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AK9981-0100 | Akron Biotech | 100µg | Ask for price |
rHu Visfatin |
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AK9981-1000 | Akron Biotech | 1mg | Ask for price |
Visfatin antibody |
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PAab09847 | Lifescience Market | 100 ug | EUR 463.2 |
Visfatin Antibody |
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5907R-100 | Biovision | each | EUR 379.2 |
Visfatin Antibody |
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5907R-30T | Biovision | each | EUR 175.2 |
Visfatin Antibody |
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5908-100 | Biovision | each | EUR 424.8 |
Visfatin Antibody |
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5908-30T | Biovision | each | EUR 175.2 |
Visfatin Antibody |
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5909-100 | Biovision | each | EUR 379.2 |
Visfatin Antibody |
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5909-30T | Biovision | each | EUR 175.2 |
Hsp70 Blocking Peptide |
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33R-10632 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Hsp70 antibody, catalog no. 70R-11611 |
SIRT7 Blocking Peptide |
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33R-10633 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIRT7 antibody, catalog no. 70R-11612 |
MAPKAPK2 Blocking Peptide |
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33R-10634 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MAPKAPK2 antibody, catalog no. 70R-11613 |
CD339 Blocking Peptide |
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33R-10635 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CD339 antibody, catalog no. 70R-11614 |
PKA Blocking Peptide |
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33R-10637 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PKA antibody, catalog no. 70R-11621 |
Raf1 Blocking Peptide |
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33R-10638 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Raf1 antibody, catalog no. 70R-11622 |
Wee1 Blocking Peptide |
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33R-10639 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Wee1 antibody, catalog no. 70R-11626 |
IHH Blocking Peptide |
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33R-1064 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SLC26A1 antibody, catalog no. 70R-6562 |
GSTP1 Blocking Peptide |
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33R-10640 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GSTP1 antibody, catalog no. 70R-11628 |
TNFR1 Blocking Peptide |
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33R-10641 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TNFR1 antibody, catalog no. 70R-11629 |
LSD1 Blocking Peptide |
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33R-10642 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LSD1 antibody, catalog no. 70R-11631 |
STAT1 Blocking Peptide |
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33R-10643 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of STAT1 antibody, catalog no. 70R-11633 |
MAK10 Blocking Peptide |
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33R-10644 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MAK10 antibody, catalog no. 70R-11634 |
ACADM Blocking Peptide |
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33R-10647 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADM antibody, catalog no. 70R-11637 |
ACADL Blocking Peptide |
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33R-10649 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADL antibody, catalog no. 70R-11639 |
SLC26A1 Blocking Peptide |
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33R-1065 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CACNB2 antibody, catalog no. 70R-1508 |
ACADSB Blocking Peptide |
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33R-10650 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADSB antibody, catalog no. 70R-11649 |
ACADSB Blocking Peptide |
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33R-10651 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADSB antibody, catalog no. 70R-11656 |
Survivin Blocking Peptide |
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33R-10653 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Survivin antibody, catalog no. 70R-11659 |
Bid Blocking Peptide |
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33R-10654 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bid antibody, catalog no. 70R-11670 |
CD40L Blocking Peptide |
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33R-10655 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CD40L antibody, catalog no. 70R-11674 |
cIAP1 Blocking Peptide |
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33R-10656 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of cIAP1 antibody, catalog no. 70R-11676 |
cIAP1 Blocking Peptide |
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33R-10657 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of cIAP1 antibody, catalog no. 70R-11675 |
cIAP2 Blocking Peptide |
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33R-10658 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of cIAP2 antibody, catalog no. 70R-11677 |
XIAP Blocking Peptide |
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33R-10659 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XIAP antibody, catalog no. 70R-11678 |
CACNB2 Blocking Peptide |
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33R-1066 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LHPP antibody, catalog no. 70R-4027 |
Perforin Blocking Peptide |
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33R-10660 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Perforin antibody, catalog no. 70R-11680 |
NIK Blocking Peptide |
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33R-10665 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NIK antibody, catalog no. 70R-11685 |
TrkA Blocking Peptide |
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33R-10666 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TrkA antibody, catalog no. 70R-11686 |
AIF Blocking Peptide |
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33R-10667 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AIF antibody, catalog no. 70R-11690 |
DR6 Blocking Peptide |
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33R-10668 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DR6 antibody, catalog no. 70R-11695 |
SIRT3 Blocking Peptide |
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33R-10669 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIRT3 antibody, catalog no. 70R-11698 |
LHPP Blocking Peptide |
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33R-1067 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of UPP1 antibody, catalog no. 70R-3171 |
SIRT4 Blocking Peptide |
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33R-10670 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIRT4 antibody, catalog no. 70R-11699 |
SIRT5 Blocking Peptide |
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33R-10671 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIRT5 antibody, catalog no. 70R-11700 |
NAIP Blocking Peptide |
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33R-10672 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NAIP antibody, catalog no. 70R-11701 |
MBD2a Blocking Peptide |
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33R-10673 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MBD2a antibody, catalog no. 70R-11702 |
SALL1 Blocking Peptide |
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33R-10674 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SALL1 antibody, catalog no. 70R-11703 |
SIAH3 Blocking Peptide |
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33R-10675 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SIAH3 antibody, catalog no. 70R-11704 |
ACAD9 Blocking Peptide |
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33R-10676 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACAD9 antibody, catalog no. 70R-11705 |
ACADVL Blocking Peptide |
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33R-10677 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACADVL antibody, catalog no. 70R-11706 |
TRIM71 Blocking Peptide |
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33R-10678 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TRIM71 antibody, catalog no. 70R-11707 |
EZH2 Blocking Peptide |
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33R-10679 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EZH2 antibody, catalog no. 70R-11708 |
UPP1 Blocking Peptide |
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33R-1068 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PVRIG antibody, catalog no. 70R-6255 |
MyD88 Blocking Peptide |
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33R-10680 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MyD88 antibody, catalog no. 70R-11710 |
ACAT1 Blocking Peptide |
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33R-10681 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACAT1 antibody, catalog no. 70R-11711 |
ABAD Blocking Peptide |
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33R-10682 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ABAD antibody, catalog no. 70R-11712 |
PKB Blocking Peptide |
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33R-10683 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PKB antibody, catalog no. 70R-11713 |
GAI2 Blocking Peptide |
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33R-10684 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GAI2 antibody, catalog no. 70R-11715 |
GABP Blocking Peptide |
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33R-10685 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GABP antibody, catalog no. 70R-11716 |
TLR4 Blocking Peptide |
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33R-10686 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TLR4 antibody, catalog no. 70R-11719 |
ACAT2 Blocking Peptide |
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33R-10687 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACAT2 antibody, catalog no. 70R-11720 |
ERAB Blocking Peptide |
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33R-10688 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ERAB antibody, catalog no. 70R-11721 |
PVRIG Blocking Peptide |
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33R-1069 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EXOSC10 antibody, catalog no. 70R-4673 |
PARD3 Blocking Peptide |
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33R-10691 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PARD3 antibody, catalog no. 70R-11725 |
TCTN2 Blocking Peptide |
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33R-10692 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TCTN2 antibody, catalog no. 70R-11727 |
HADH Blocking Peptide |
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33R-10693 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HADH antibody, catalog no. 70R-11728 |
FATP4 Blocking Peptide |
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33R-10696 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FATP4 antibody, catalog no. 70R-11731 |
Bid Blocking Peptide |
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33R-10697 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bid antibody, catalog no. 70R-11734 |
JMJD1A Blocking Peptide |
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33R-10698 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of JMJD1A antibody, catalog no. 70R-11735 |
RIP Blocking Peptide |
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33R-10699 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RIP antibody, catalog no. 70R-11737 |
EXOSC10 Blocking Peptide |
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33R-1070 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MKRN2 antibody, catalog no. 70R-2131 |
MBD1 Blocking Peptide |
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33R-10700 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of MBD1 antibody, catalog no. 70R-11739 |
VENTX Blocking Peptide |
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33R-10702 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of VENTX antibody, catalog no. 70R-11742 |
ASC Blocking Peptide |
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33R-10703 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ASC antibody, catalog no. 70R-11744 |
RIP3 Blocking Peptide |
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33R-10704 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RIP3 antibody, catalog no. 70R-11745 |
SMAC Blocking Peptide |
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33R-10705 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SMAC antibody, catalog no. 70R-11747 |
RasGAP Blocking Peptide |
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33R-10706 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RasGAP antibody, catalog no. 70R-11749 |
TCTN3 Blocking Peptide |
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33R-10708 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TCTN3 antibody, catalog no. 70R-11753 |
BMF Blocking Peptide |
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33R-10709 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BMF antibody, catalog no. 70R-11754 |
MKRN2 Blocking Peptide |
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33R-1071 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AMZ2 antibody, catalog no. 70R-9376 |
EndoG Blocking Peptide |
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33R-10710 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of EndoG antibody, catalog no. 70R-11755 |
ILP2 Blocking Peptide |
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33R-10711 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ILP2 antibody, catalog no. 70R-11756 |
PUMA Blocking Peptide |
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33R-10712 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PUMA antibody, catalog no. 70R-11758 |
p53NIDP1 Blocking Peptide |
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33R-10713 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of p53NIDP1 antibody, catalog no. 70R-11759 |
POU2F1 Blocking Peptide |
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33R-10714 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of POU2F1 antibody, catalog no. 70R-11760 |
FasL Blocking Peptide |
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33R-10715 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FasL antibody, catalog no. 70R-11761 |
FAF1 Blocking Peptide |
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33R-10716 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of FAF1 antibody, catalog no. 70R-11762 |
BI1 Blocking Peptide |
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33R-10717 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BI1 antibody, catalog no. 70R-11763 |
TANK Blocking Peptide |
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33R-10718 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TANK antibody, catalog no. 70R-11764 |
PCNA Blocking Peptide |
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33R-10719 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PCNA antibody, catalog no. 70R-11765 |
AMZ2 Blocking Peptide |
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33R-1072 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of RNF32 antibody, catalog no. 70R-1166 |
ALK Blocking Peptide |
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33R-10723 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ALK antibody, catalog no. 70R-11769 |
CREB Blocking Peptide |
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33R-10725 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CREB antibody, catalog no. 70R-11772 |
COX1 Blocking Peptide |
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33R-10726 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of COX1 antibody, catalog no. 70R-11773 |
COX1 Blocking Peptide |
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33R-10727 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of COX1 antibody, catalog no. 70R-11774 |
BLCAM Blocking Peptide |
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33R-10728 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BLCAM antibody, catalog no. 70R-11775 |
BRCA1 Blocking Peptide |
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33R-10729 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BRCA1 antibody, catalog no. 70R-11776 |
RNF32 Blocking Peptide |
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33R-1073 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GOLGA7 antibody, catalog no. 70R-2903 |
Cadherin Blocking Peptide |
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33R-10730 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Cadherin antibody, catalog no. 70R-11777 |
TFPI Blocking Peptide |
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33R-10735 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TFPI antibody, catalog no. 70R-11785 |
Hsp90 Blocking Peptide |
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33R-10737 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Hsp90 antibody, catalog no. 70R-11793 |
Hsp105 Blocking Peptide |
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33R-10738 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Hsp105 antibody, catalog no. 70R-11794 |
HMOX1 Blocking Peptide |
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33R-10739 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HMOX1 antibody, catalog no. 70R-11795 |
GOLGA7 Blocking Peptide |
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33R-1074 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ACSL5 antibody, catalog no. 70R-6556 |
HMOX2 Blocking Peptide |
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33R-10740 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HMOX2 antibody, catalog no. 70R-11796 |
HCAM Blocking Peptide |
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33R-10741 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HCAM antibody, catalog no. 70R-11797 |
BMX Blocking Peptide |
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33R-10742 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BMX antibody, catalog no. 70R-11799 |
BMX Blocking Peptide |
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33R-10743 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BMX antibody, catalog no. 70R-11800 |
A1 Blocking Peptide |
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33R-10744 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of A1 antibody, catalog no. 70R-11802 |
AFX Blocking Peptide |
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33R-10745 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AFX antibody, catalog no. 70R-11803 |
BCL3 Blocking Peptide |
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33R-10746 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BCL3 antibody, catalog no. 70R-11804 |
BCL6 Blocking Peptide |
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33R-10747 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of BCL6 antibody, catalog no. 70R-11805 |
ACSL5 Blocking Peptide |
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33R-1075 | Fitzgerald | 100 ug | EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CCND1 antibody, catalog no. 70R-10480 |
CETP Blocking Peptide |
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33R-10750 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CETP antibody, catalog no. 70R-11808 |
CCR1 Blocking Peptide |
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33R-10751 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CCR1 antibody, catalog no. 70R-11809 |
CCR2 Blocking Peptide |
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33R-10752 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CCR2 antibody, catalog no. 70R-11810 |
CCR3 Blocking Peptide |
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33R-10753 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CCR3 antibody, catalog no. 70R-11811 |
CXCR5 Blocking Peptide |
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33R-10754 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of CXCR5 antibody, catalog no. 70R-11812 |
GADD153 Blocking Peptide |
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33R-10755 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GADD153 antibody, catalog no. 70R-11813 |
ICAM1 Blocking Peptide |
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33R-10756 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ICAM1 antibody, catalog no. 70R-11814 |
ILK1 Blocking Peptide |
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33R-10757 | Fitzgerald | 50 ug | EUR 229.2 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ILK1 antibody, catalog no. 70R-11815 |