Cellulaire veroudering bij hepatocellulair carcinoom geïnduceerd door een lang niet-coderend RNA-gecodeerd peptide PINT87aa door FOXM1-gemedieerde PHB2 te blokkeren
Rationale: Onlangs is aangetoond dat lange niet-coderende RNA’s (lncRNA’s), waarvan bekend is dat ze betrokken zijn bij de progressie van kanker bij de mens, coderen voor peptiden met biologische functies, maar de rol van door lncRNA gecodeerde peptiden bij cellulaire veroudering is grotendeels onontgonnen. We rapporteerden eerder de tumor-onderdrukkende rol van PINT87aa, een peptide dat wordt gecodeerd door het lange intergene niet-eiwit coderende RNA, p53-geïnduceerde transcript ( LINC-PINT). Hier hebben we de rol van PINT87aa bij cellulaire senescentie van hepatocellulair carcinoom (HCC) onderzocht.
Methoden: We onderzochten de functies van PINT87aa en afgeknotte PINT87aa in vitro door celproliferatie te volgen en voerden flowcytometrie uit, senescentie-geassocieerde β-galactosidase-kleuring, JC-1-kleuring die indicatief is voor mitochondriaal membraanpotentieel, de verhouding van het overlappende gebied van lichte keten Three bèta ( LC3B) en mitochondriale sondes en de verhouding van lysosomaal geassocieerd membraaneiwit 1 (LAMP1) overlapt met cytochroom c-oxidase-subeenheid 4I1 (COXIV) die mitofagie aangeeft. PINT87aa en afgeknotte PINT87aa-functies in vivo werden geverifieerd door subcutaan getransplanteerde tumoren in naakte muizen. De mogelijke binding tussen PINT87aa en forkhead subject M1 (FOXM1) werd voorspeld door middel van structurele analyse en geverifieerd door co-immunoprecipitatie en immunofluorescentie co-lokalisatie. Rescue-experimenten werden in vivo en in vitro uitgevoerd na overexpressie van FOXM1. Verder werden chromatine-immunoprecipitatie, polymerasekettingreactie en dual-luciferase-reportergentest uitgevoerd om FOXM1-binding aan de prohibitine 2 ( PHB2 ) -promotor te valideren .
Resultaten: PINT87aa was necessary verhoogd in het door waterstofperoxide geïnduceerde HCC-celsenescentiemodel. Overexpressie van PINT87aa induceerde groeiremming, cellulaire veroudering en verminderde mitofagie in vitro en in vivo . Daarentegen zou FOXM1 gain-of-function het aandeel senescente HCC-cellen gedeeltelijk kunnen verminderen en de mitofagie kunnen verbeteren. PINT87aa-overexpressie had geen invloed op de expressie van FOXM1 zelf, maar verminderde die van zijn doelwitgenen die betrokken zijn bij celcyclus en proliferatie, met establish PHB2, die betrokken was bij mitofagie en getranscribeerd door FOXM1. Structurele analyse gaf aan dat PINT87aa kon binden aan het DNA-bindende domein van FOXM1, wat werd bevestigd door co-immunoprecipitatie en immunofluorescentie co-lokalisatie. Verder hebben we aangetoond dat de afgeknotte vorm van 2 tot 39 aminozuren van het peptide effecten uitoefende die vergelijkbaar waren met de volledige vorm.
Conclusie: Onze studie stelde de rol enormous van PINT87aa als een nieuwe biomarker en een belangrijke regulator van cellulaire veroudering in HCC en identificeerde PINT87aa als een potentieel therapeutisch doelwit voor HCC.
 UCP5 Polyclonal Antibody |
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| ES9457-100ul | ELK Biotech | 100ul | EUR 279 |
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Description: A Rabbit Polyclonal antibody against UCP5 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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UCP5 Polyclonal Antibody |
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| ES9457-50ul | ELK Biotech | 50ul | EUR 207 |
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Description: A Rabbit Polyclonal antibody against UCP5 from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA |
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 anti- UCP5 antibody |
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| FNab09230 | FN Test | 100µg | EUR 585 |
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Description: Antibody raised against UCP5 |
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 Substance P reversed sequence Peptide |
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| 20-abx266314 | Abbexa |
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 Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0001 | Bachem | 1.0mg | EUR 454 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0005 | Bachem | 5.0mg | EUR 1723 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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 UCP5 ELISA KIT|Human |
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| EF004049 | Lifescience Market | 96 Tests | EUR 689 |
) NET Blocking Peptide (Rat) |
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| 30R-AN036 | Fitzgerald | 100 ug | EUR 241 |
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Description: A synthetic NET Blocking peptide for use as a blocking control in assays to test for specificity of NET antibody, catalog no. 70R-NR004 |
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) UCP3 Blocking Peptide (Rat) |
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| 30R-AU003 | Fitzgerald | 100 ug | EUR 256 |
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Description: A synthetic UCP3 Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 antibody, catalog no. 70R-UR005 |
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 Rat Calnuc Blocking Peptide |
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| 33R-2673 | Fitzgerald | 100 ug | EUR 180 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NUCB1 antibody, catalog no. 70R-1118 |
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 Rat C-Peptide ELISA Kit |
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| DLR-C-Peptide-Ra-48T | DL Develop | 48T | EUR 467 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Rat C-Peptide ELISA Kit |
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| DLR-C-Peptide-Ra-96T | DL Develop | 96T | EUR 605 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Rat C-Peptide ELISA Kit |
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| RD-C-Peptide-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 465 |
Rat C-Peptide ELISA Kit |
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| RD-C-Peptide-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 643 |
Rat C-Peptide ELISA Kit |
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| RDR-C-Peptide-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 486 |
Rat C-Peptide ELISA Kit |
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| RDR-C-Peptide-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 672 |
5 peptide (repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide) (NANP)5 peptide (repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide |
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| NANP51-P | Alpha Diagnostics | 1 mg | EUR 347 |
3 peptide (repeat-sequence peptide of the P. berghei circumsporozoite protein, CSP) control/blocking peptide) (PPPPNAND)3 peptide (repeat-sequence peptide of the P. berghei circumsporozoite protein, CSP) control/blocking peptide |
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| PPPP321-P | Alpha Diagnostics | 100 ug | EUR 164 |
) Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
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| RAT-5 | Alpha Diagnostics | 1 | EUR 1138 |
4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide) (NVDP)4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide |
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| NVDP41-P | Alpha Diagnostics | 100 ug | EUR 164 |
 matrix protein 2 hybrid sequence Control/blocking peptide) Influenza A virus (H5N1) matrix protein 2 hybrid sequence Control/blocking peptide |
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| M2E11-P | Alpha Diagnostics | 100 ug | EUR 164 |
3 (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) control/blocking peptide) (DRAAGQPAG)3 (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) control/blocking peptide |
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| DRAA31-P | Alpha Diagnostics | 100 ug | EUR 164 |
 Rat GTRAP41 Control/blocking peptide |
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| GTRAP41-P | Alpha Diagnostics | 100 ug | EUR 164 |
 Rat GTRAP48 Control/blocking peptide |
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| GTRAP48-P | Alpha Diagnostics | 100 ug | EUR 164 |
 C-Peptide Blocking Peptide |
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| 3277BP-50 | Biovision | EUR 153 | |
 ELNE Blocking Peptide |
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| AF0010-BP | Affbiotech | 1mg | EUR 195 |
 ERLN2 Blocking Peptide |
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| AF0011-BP | Affbiotech | 1mg | EUR 195 |
 CAPG Blocking Peptide |
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| AF0012-BP | Affbiotech | 1mg | EUR 195 |
CAPG Blocking Peptide |
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| AF0013-BP | Affbiotech | 1mg | EUR 195 |
 CD28 Blocking Peptide |
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| AF0014-BP | Affbiotech | 1mg | EUR 195 |
 RYR2 Blocking Peptide |
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| AF0015-BP | Affbiotech | 1mg | EUR 195 |
 CD31 Blocking Peptide |
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| AF0077-BP | Affbiotech | 1mg | EUR 195 |
 Bax Blocking Peptide |
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| AF0083-BP | Affbiotech | 1mg | EUR 195 |
 hnRPD Blocking Peptide |
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| AF0092-BP | Affbiotech | 1mg | EUR 195 |
 eNOS Blocking Peptide |
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| AF0096-BP | Affbiotech | 1mg | EUR 195 |
 HSF1 Blocking Peptide |
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| AF0098-BP | Affbiotech | 1mg | EUR 195 |
 TTK Blocking Peptide |
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| AF0102-BP | Affbiotech | 1mg | EUR 195 |
 FRS2 Blocking Peptide |
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| AF0103-BP | Affbiotech | 1mg | EUR 195 |
 Gab2 Blocking Peptide |
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| AF0106-BP | Affbiotech | 1mg | EUR 195 |
 APLF Blocking Peptide |
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| AF0108-BP | Affbiotech | 1mg | EUR 195 |
 RAD17 Blocking Peptide |
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| AF0110-BP | Affbiotech | 1mg | EUR 195 |
 RON Blocking Peptide |
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| AF0111-BP | Affbiotech | 1mg | EUR 195 |
 APAF1 Blocking Peptide |
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| AF0117-BP | Affbiotech | 1mg | EUR 195 |
 ARC Blocking Peptide |
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| AF0118-BP | Affbiotech | 1mg | EUR 195 |
 Bak Blocking Peptide |
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| AF0119-BP | Affbiotech | 1mg | EUR 195 |
Bax Blocking Peptide |
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| AF0120-BP | Affbiotech | 1mg | EUR 195 |
 BIM Blocking Peptide |
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| AF0121-BP | Affbiotech | 1mg | EUR 195 |
 CARD6 Blocking Peptide |
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| AF0123-BP | Affbiotech | 1mg | EUR 195 |
 Fos Blocking Peptide |
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| AF0132-BP | Affbiotech | 1mg | EUR 195 |
 Cox1 Blocking Peptide |
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| AF0138-BP | Affbiotech | 1mg | EUR 195 |
 Desmin Blocking Peptide |
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| AF0147-BP | Affbiotech | 1mg | EUR 195 |
 TFDP1 Blocking Peptide |
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| AF0149-BP | Affbiotech | 1mg | EUR 195 |
 Dysferlin Blocking Peptide |
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| AF0150-BP | Affbiotech | 1mg | EUR 195 |
 E2F4 Blocking Peptide |
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| AF0151-BP | Affbiotech | 1mg | EUR 195 |
 E2F6 Blocking Peptide |
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| AF0152-BP | Affbiotech | 1mg | EUR 195 |
 ERCC1 Blocking Peptide |
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| AF0154-BP | Affbiotech | 1mg | EUR 195 |
 FASL Blocking Peptide |
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| AF0157-BP | Affbiotech | 1mg | EUR 195 |
 FGFR2 Blocking Peptide |
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| AF0159-BP | Affbiotech | 1mg | EUR 195 |
 FGFR3 Blocking Peptide |
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| AF0160-BP | Affbiotech | 1mg | EUR 195 |
 FLI1 Blocking Peptide |
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| AF0161-BP | Affbiotech | 1mg | EUR 195 |
 GABBR1 Blocking Peptide |
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| AF0162-BP | Affbiotech | 1mg | EUR 195 |
 GAD1 Blocking Peptide |
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| AF0163-BP | Affbiotech | 1mg | EUR 195 |
 GANP Blocking Peptide |
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| AF0165-BP | Affbiotech | 1mg | EUR 195 |
 mGluR4 Blocking Peptide |
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| AF0168-BP | Affbiotech | 1mg | EUR 195 |
 GluR5 Blocking Peptide |
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| AF0169-BP | Affbiotech | 1mg | EUR 195 |
 mGluR6 Blocking Peptide |
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| AF0170-BP | Affbiotech | 1mg | EUR 195 |
 mGluR7 Blocking Peptide |
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| AF0171-BP | Affbiotech | 1mg | EUR 195 |
 mGluR8 Blocking Peptide |
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| AF0172-BP | Affbiotech | 1mg | EUR 195 |
 GLUT1 Blocking Peptide |
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| AF0173-BP | Affbiotech | 1mg | EUR 195 |
 GLUT3 Blocking Peptide |
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| AF0174-BP | Affbiotech | 1mg | EUR 195 |
 GRP75 Blocking Peptide |
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| AF0176-BP | Affbiotech | 1mg | EUR 195 |
 HDAC1 Blocking Peptide |
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| AF0178-BP | Affbiotech | 1mg | EUR 195 |
 HDAC10 Blocking Peptide |
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| AF0179-BP | Affbiotech | 1mg | EUR 195 |
 HDAC7 Blocking Peptide |
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| AF0180-BP | Affbiotech | 1mg | EUR 195 |
 HDAC9 Blocking Peptide |
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| AF0181-BP | Affbiotech | 1mg | EUR 195 |
 HSP10 Blocking Peptide |
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| AF0183-BP | Affbiotech | 1mg | EUR 195 |
 HSP60 Blocking Peptide |
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| AF0184-BP | Affbiotech | 1mg | EUR 195 |
 Involucrin Blocking Peptide |
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| AF0186-BP | Affbiotech | 1mg | EUR 195 |
 COPS3 Blocking Peptide |
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| AF0187-BP | Affbiotech | 1mg | EUR 195 |
 JM4 Blocking Peptide |
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| AF0188-BP | Affbiotech | 1mg | EUR 195 |
 Ki67 Blocking Peptide |
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| AF0198-BP | Affbiotech | 1mg | EUR 195 |
 iNOS Blocking Peptide |
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| AF0199-BP | Affbiotech | 1mg | EUR 195 |
 Ku80 Blocking Peptide |
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| AF0200-BP | Affbiotech | 1mg | EUR 195 |
 Ku70 Blocking Peptide |
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| AF0201-BP | Affbiotech | 1mg | EUR 195 |
 Mammaglobin Blocking Peptide |
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| AF0202-BP | Affbiotech | 1mg | EUR 195 |
 MLANA Blocking Peptide |
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| AF0204-BP | Affbiotech | 1mg | EUR 195 |
 MCL1 Blocking Peptide |
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| AF0205-BP | Affbiotech | 1mg | EUR 195 |
 MCM2 Blocking Peptide |
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| AF0206-BP | Affbiotech | 1mg | EUR 195 |
 MCM5 Blocking Peptide |
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| AF0207-BP | Affbiotech | 1mg | EUR 195 |
 MDM2 Blocking Peptide |
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| AF0208-BP | Affbiotech | 1mg | EUR 195 |
 MMP1 Blocking Peptide |
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| AF0209-BP | Affbiotech | 1mg | EUR 195 |
 MMP11 Blocking Peptide |
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| AF0211-BP | Affbiotech | 1mg | EUR 195 |
 MMP14 Blocking Peptide |
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| AF0212-BP | Affbiotech | 1mg | EUR 195 |
 MMP15 Blocking Peptide |
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| AF0213-BP | Affbiotech | 1mg | EUR 195 |
 MMP16 Blocking Peptide |
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| AF0214-BP | Affbiotech | 1mg | EUR 195 |
 MMP19 Blocking Peptide |
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| AF0215-BP | Affbiotech | 1mg | EUR 195 |
 MMP23 Blocking Peptide |
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| AF0216-BP | Affbiotech | 1mg | EUR 195 |
 MMP3 Blocking Peptide |
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| AF0217-BP | Affbiotech | 1mg | EUR 195 |
 MMP7 Blocking Peptide |
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| AF0218-BP | Affbiotech | 1mg | EUR 195 |
 MMP8 Blocking Peptide |
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| AF0219-BP | Affbiotech | 1mg | EUR 195 |
 MMP9 Blocking Peptide |
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| AF0220-BP | Affbiotech | 1mg | EUR 195 |
 NKX3.1 Blocking Peptide |
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| AF0221-BP | Affbiotech | 1mg | EUR 195 |
 NM23 Blocking Peptide |
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| AF0222-BP | Affbiotech | 1mg | EUR 195 |
 NSE Blocking Peptide |
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| AF0223-BP | Affbiotech | 1mg | EUR 195 |
 OCT1 Blocking Peptide |
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| AF0224-BP | Affbiotech | 1mg | EUR 195 |
 OCT2 Blocking Peptide |
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| AF0225-BP | Affbiotech | 1mg | EUR 195 |
 OCT3 Blocking Peptide |
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| AF0226-BP | Affbiotech | 1mg | EUR 195 |
 Osteopontin Blocking Peptide |
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| AF0227-BP | Affbiotech | 1mg | EUR 195 |
 PCAF Blocking Peptide |
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| AF0231-BP | Affbiotech | 1mg | EUR 195 |
 p63 Blocking Peptide |
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| AF0233-BP | Affbiotech | 1mg | EUR 195 |
 Parkin Blocking Peptide |
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| AF0235-BP | Affbiotech | 1mg | EUR 195 |
 Patched Blocking Peptide |
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| AF0237-BP | Affbiotech | 1mg | EUR 195 |
 PCNA Blocking Peptide |
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| AF0239-BP | Affbiotech | 1mg | EUR 195 |
 PDGFB Blocking Peptide |
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| AF0240-BP | Affbiotech | 1mg | EUR 195 |
 PDGFRalpha Blocking Peptide |
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| AF0241-BP | Affbiotech | 1mg | EUR 195 |
 Peripherin Blocking Peptide |
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| AF0242-BP | Affbiotech | 1mg | EUR 195 |
 PGP9.5 Blocking Peptide |
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| AF0243-BP | Affbiotech | 1mg | EUR 195 |
 KCNC2 Blocking Peptide |
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| AF0244-BP | Affbiotech | 1mg | EUR 195 |
 KLK3 Blocking Peptide |
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| AF0246-BP | Affbiotech | 1mg | EUR 195 |
 RCBTB1 Blocking Peptide |
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| AF0248-BP | Affbiotech | 1mg | EUR 195 |
 RIT1 Blocking Peptide |
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| AF0250-BP | Affbiotech | 1mg | EUR 195 |
 SHIP1 Blocking Peptide |
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| AF0252-BP | Affbiotech | 1mg | EUR 195 |
 SHPS1 Blocking Peptide |
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| AF0253-BP | Affbiotech | 1mg | EUR 195 |
 SNAP25 Blocking Peptide |
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| AF0254-BP | Affbiotech | 1mg | EUR 195 |
 CSTB Blocking Peptide |
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| AF0256-BP | Affbiotech | 1mg | EUR 195 |
 Synaptophysin Blocking Peptide |
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| AF0257-BP | Affbiotech | 1mg | EUR 195 |
 TGFR2 Blocking Peptide |
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| AF0259-BP | Affbiotech | 1mg | EUR 195 |
 TGFB3 Blocking Peptide |
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| AF0261-BP | Affbiotech | 1mg | EUR 195 |
 TIMP2 Blocking Peptide |
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| AF0264-BP | Affbiotech | 1mg | EUR 195 |
 TIMP3 Blocking Peptide |
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| AF0265-BP | Affbiotech | 1mg | EUR 195 |
 AOS1 Blocking Peptide |
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| AF0266-BP | Affbiotech | 1mg | EUR 195 |
 CDK7 Blocking Peptide |
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| AF0267-BP | Affbiotech | 1mg | EUR 195 |
 EDD Blocking Peptide |
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| AF0268-BP | Affbiotech | 1mg | EUR 195 |
 HAT Blocking Peptide |
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| AF0269-BP | Affbiotech | 1mg | EUR 195 |
 NCoR1 Blocking Peptide |
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| AF0270-BP | Affbiotech | 1mg | EUR 195 |
 NEDD8 Blocking Peptide |
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| AF0271-BP | Affbiotech | 1mg | EUR 195 |
 NYREN18 Blocking Peptide |
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| AF0272-BP | Affbiotech | 1mg | EUR 195 |
 PIAS2 Blocking Peptide |
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| AF0273-BP | Affbiotech | 1mg | EUR 195 |
 PIAS3 Blocking Peptide |
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| AF0274-BP | Affbiotech | 1mg | EUR 195 |
 SENP1 Blocking Peptide |
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| AF0275-BP | Affbiotech | 1mg | EUR 195 |
 SENP5 Blocking Peptide |
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| AF0276-BP | Affbiotech | 1mg | EUR 195 |
 SENP6 Blocking Peptide |
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| AF0277-BP | Affbiotech | 1mg | EUR 195 |
 SENP7 Blocking Peptide |
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| AF0278-BP | Affbiotech | 1mg | EUR 195 |
 SENP8 Blocking Peptide |
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| AF0279-BP | Affbiotech | 1mg | EUR 195 |
 Sumo1 Blocking Peptide |
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| AF0280-BP | Affbiotech | 1mg | EUR 195 |
 TIMP4 Blocking Peptide |
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| AF0281-BP | Affbiotech | 1mg | EUR 195 |
 TNFR1 Blocking Peptide |
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| AF0282-BP | Affbiotech | 1mg | EUR 195 |
 TOP2B Blocking Peptide |
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| AF0283-BP | Affbiotech | 1mg | EUR 195 |
 TRADD Blocking Peptide |
|||
| AF0284-BP | Affbiotech | 1mg | EUR 195 |
 Tyrosinase Blocking Peptide |
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| AF0286-BP | Affbiotech | 1mg | EUR 195 |
 Uba2 Blocking Peptide |
|||
| AF0287-BP | Affbiotech | 1mg | EUR 195 |
 UBE1L Blocking Peptide |
|||
| AF0288-BP | Affbiotech | 1mg | EUR 195 |
 Ubiquitin Blocking Peptide |
|||
| AF0289-BP | Affbiotech | 1mg | EUR 195 |
 Urocortin Blocking Peptide |
|||
| AF0290-BP | Affbiotech | 1mg | EUR 195 |
 USF2 Blocking Peptide |
|||
| AF0291-BP | Affbiotech | 1mg | EUR 195 |
 Vimentin Blocking Peptide |
|||
| AF0292-BP | Affbiotech | 1mg | EUR 195 |
 RPL10 Blocking Peptide |
|||
| AF0293-BP | Affbiotech | 1mg | EUR 195 |
 XPA Blocking Peptide |
|||
| AF0294-BP | Affbiotech | 1mg | EUR 195 |
 XPF Blocking Peptide |
|||
| AF0295-BP | Affbiotech | 1mg | EUR 195 |
 XRCC1 Blocking Peptide |
|||
| AF0296-BP | Affbiotech | 1mg | EUR 195 |
 XRCC3 Blocking Peptide |
|||
| AF0298-BP | Affbiotech | 1mg | EUR 195 |
 XRCC4 Blocking Peptide |
|||
| AF0299-BP | Affbiotech | 1mg | EUR 195 |
 TM16J Blocking Peptide |
|||
| AF0301-BP | Affbiotech | 1mg | EUR 195 |
 NKX6.3 Blocking Peptide |
|||
| AF0302-BP | Affbiotech | 1mg | EUR 195 |
 PDLIM1 Blocking Peptide |
|||
| AF0303-BP | Affbiotech | 1mg | EUR 195 |
 DR4 Blocking Peptide |
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| AF0304-BP | Affbiotech | 1mg | EUR 195 |
Biocide werkzaamheid van tutine en de invloed ervan op immuuncellen en expressie van groeiremmende en neurogliale peptiden in Mythimna separata (Lepidoptera: Noctuidae)
Mythimna separata Walker (Lepidoptera: Noctuidae) is een van de belangrijkste plagen die ernstige schade aan graangewassen kan veroorzaken. De ontwikkeling van botanische insecticiden met een lage toxiciteit en hoge prestaties wordt de focus van nieuw onderzoek naar pesticiden om M. separata te bestrijden. Tutin, een sesquiterpeenlactonverbinding die wordt verkregen uit Coriaria sinica Maxim, een inheemse Chinese language language giftige plant, heeft een antivoedingsmiddel, absorptie en maagvergiftiging tegen een verscheidenheid aan plagen. Om het toxische impression van tutine op de larven van M. separata te begrijpen, wilden we hun anti-voedingsmiddel, mortaliteit, verlamming, gewichtsverandering bepalen en de verspreiding van M. separata hemocyten onder verschillende concentraties van tutinebehandeling onderzoeken.
Weefselverdeling van het immuun-geassocieerde gengroei-blokkerende peptide (GBP) en neuroglian peptide (Nrg) werd gedetecteerd door reverse transcriptie polymerase kettingreactie (PCR). Verder werd real-time kwantitatieve PCR uitgevoerd om de expressieprofielen van GBP en Nrg te bepalen na verschillende concentraties van tutine-stimulatie. Onze resultaten onthulden dat tutine significante anti-feedant en insecticide activiteiten, verlamming, gewichtsverlies voor M. separata vertoonde . Bovendien had tutine een significante invloed op de morfologie van hemocyten en versterkte het de expressie van GBP en Nrg in M. separata.
Van stress afgeleide reactieve zuurstofsoorten stellen hemocyten in staat om activator van groeiblokkerend peptide (GBP) -verwerkingsenzym af te geven
Insectencytokinegroeiblokkerend peptide (GBP) wordt gesynthetiseerd als een inactieve voorloper, proGBP genaamd, die normaal in een significante concentratie aanwezig is in de hemolymfe van dieren zonder stress (Hayakawa, 1990, 1991). Onder stressomstandigheden wordt proGBP onmiddellijk omgezet tot actief GBP door een serineprotease en males denkt dat dit een belangrijke eerste stap is voor insecten om het hoofd te bieden aan door stress veroorzaakte nadelige effecten by the use of GBP-geïnduceerde fysiologische veranderingen.
Het gedetailleerde mechanisme dat ten grondslag ligt aan de proteolytische verwerking van hemolymfe proGBP bij insecten onder stressomstandigheden blijft echter onbekend. Hier hebben we aangetoond dat proGBP-verwerking door ROS geïnduceerde afgifte van een eiwitachtige concern uit hemocyten vereist die het inactieve proGBP-verwerkingsenzym activeert. De afgifte van het activatoreiwit uit hemocyten wordt geïnitieerd door een verhoging van de cytoplasmatische Ca2 + -concentratie, geïnduceerd door ROS. Daarom concludeerden we dat door stress geïnduceerde activering van proGBP ROS-afhankelijke stimulatie van een intracellulaire calciumsignaleringsroute in hemocyten vereist, gevolgd door afgifte van de hemocyt-eiwitachtige concern die specifiek het proGBP-verwerkingsenzym activeert.
Lipopolysacharide beïnvloedt het plasma en hersenen farmacokinetiek van subcutaan toegediende HsTX1 [R14a], Okay V 1,3-blokkerende peptide
Okay<sub>V</sub>1.Three is een spanningsafhankelijk kaliumkanaal dat wordt opgereguleerd bij neuro-inflammatoire aandoeningen, zoals de ziekte van Alzheimer en de ziekte van Parkinson. HsTX1[R14A] is een krachtige en selectieve peptideblokker van Okay<sub>V</sub>1.Three met het potentieel om microgliale Okay<sub>V</sub>1.Three te blokkeren, maar de opname in de hersenen zal naar verwachting beperkt zijn vanwege de beperkende aard van de bloed-hersenbarrière. Om de perifere en hersenblootstelling te beoordelen , werd een LC-MS/MS-assay ontwikkeld om HsTX1[R14A]-concentraties in muizenplasma en hersenhomogenaat te kwantificeren die betrouwbaar en reproduceerbaar waren in het bereik van 6,7-66,7 nM (r<sup>2< /sup> = 0,9765) en 15-150 pmol/g (r<sup>2</sup> = 0,9984), respectievelijk.
Om te beoordelen of neuro-inflammatie de HsTX1[R14A]-dispositie beïnvloedde, kregen C57BL/6-muizen HsTX1[R14A] subcutaan (2 mg/kg) 24 uur na een intraperitoneale dosis Escherichia coli lipopolysaccharide (LPS), die vaak wordt gebruikt om neuro-inflammatie te induceren; hersen- en plasmaconcentraties van HsTX1[R14A] werden vervolgens gedurende 120 minuten gekwantificeerd. LPS-behandelingvertraagde de daling van de HsTX1[R14A]-plasmaconcentraties aanzienlijk, vermoedelijk als gevolg van een verminderde renale klaring, en leidde tot een substantiële opname van HsTX1[R14A] in de hersenen, vermoedelijk door verstoring van de inter-endotheliale tight junctions in de hersenen. Deze studie suggereert dat HsTX1[R14A] microglia kan bereiken in voldoende concentraties om Okay<sub>V</sub>1.Three te blokkeren bij neuro-inflammatoire aandoeningen, en daarom het potentieel heeft om neurodegeneratieve ziekten te verminderen.
 ELISA Kit) Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| DLR-UCP2-Ra-96T | DL Develop | 96T | EUR 718 |
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Uncoupling Protein 2, Mitochondrial (UCP2) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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 ELISA Kit) Human Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RD-UCP2-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 521 |
Human Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RD-UCP2-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 723 |
Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RD-UCP2-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 557 |
Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RD-UCP2-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 775 |
Human Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RDR-UCP2-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 544 |
Human Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RDR-UCP2-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 756 |
Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RDR-UCP2-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 583 |
Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RDR-UCP2-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 811 |
Substance P reversed sequence Peptide |
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| 20-abx266314 | Abbexa |
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0001 | Bachem | 1.0mg | EUR 454 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0005 | Bachem | 5.0mg | EUR 1723 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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 mouse Splunc2 Blocking Peptide |
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| BF0461-BP | Affbiotech | 1mg | EUR 195 |
) GLUT4 Blocking peptide (Mouse) |
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| 30R-AG010 | Fitzgerald | 100 ug | EUR 241 |
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Description: A synthetic GLUT4 Blocking peptide for use as a blocking control in assays to test for specificity of GLUT4 antibody, catalog no. 70R-GR014 |
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) GLUT8 Blocking Peptide (Mouse) |
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| 30R-AG011 | Fitzgerald | 100 ug | EUR 241 |
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Description: A synthetic GLUT8 Blocking peptide for use as a blocking control in assays to test for specificity of GLUT8 antibody, catalog no. 70R-GR008 |
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(NANP)5 peptide (repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide |
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| NANP51-P | Alpha Diagnostics | 1 mg | EUR 347 |
(PPPPNAND)3 peptide (repeat-sequence peptide of the P. berghei circumsporozoite protein, CSP) control/blocking peptide |
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| PPPP321-P | Alpha Diagnostics | 100 ug | EUR 164 |
) UCP2 Recombinant Protein (Mouse) |
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| RP182948 | ABM | 100 ug | Ask for price |
 Mouse UCP2 shRNA Plasmid |
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| 20-abx973302 | Abbexa |
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 Mouse C-Peptide ELISA Kit |
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| DLR-C-Peptide-Mu-48T | DL Develop | 48T | EUR 450 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse C-Peptide ELISA Kit |
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| DLR-C-Peptide-Mu-96T | DL Develop | 96T | EUR 582 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse C-Peptide ELISA Kit |
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| RD-C-Peptide-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 446 |
Mouse C-Peptide ELISA Kit |
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| RD-C-Peptide-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 615 |
Mouse C-Peptide ELISA Kit |
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| RDR-C-Peptide-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 465 |
Mouse C-Peptide ELISA Kit |
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| RDR-C-Peptide-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 643 |
(NVDP)4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide |
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| NVDP41-P | Alpha Diagnostics | 100 ug | EUR 164 |
(DRAAGQPAG)3 (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) control/blocking peptide |
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| DRAA31-P | Alpha Diagnostics | 100 ug | EUR 164 |
Influenza A virus (H5N1) matrix protein 2 hybrid sequence Control/blocking peptide |
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| M2E11-P | Alpha Diagnostics | 100 ug | EUR 164 |
 UCP2 antibody |
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| 70R-UR002 | Fitzgerald | 100 ug | EUR 640 |
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Description: Affinity purified Rabbit polyclonal UCP2 antibody |
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UCP2 antibody |
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| 70R-UR003 | Fitzgerald | 100 ug | EUR 640 |
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Description: Affinity purified Rabbit polyclonal UCP2 antibody |
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 UCP2 Antibody |
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| ABD8626 | Lifescience Market | 100 ug | EUR 438 |
 anti-UCP2 |
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| YF-PA15210 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to UCP2 |
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anti-UCP2 |
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| YF-PA15211 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to UCP2 |
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anti-UCP2 |
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| YF-PA15212 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse polyclonal to UCP2 |
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anti-UCP2 |
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| YF-PA15213 | Abfrontier | 100 ug | EUR 403 |
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Description: Rabbit polyclonal to UCP2 |
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UCP2 antibody |
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| 20R-UR001 | Fitzgerald | 100 ug | EUR 673 |
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Description: Rabbit polyclonal UCP2 antibody |
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UCP2 antibody |
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| 70R-21145 | Fitzgerald | 50 ul | EUR 435 |
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Description: Rabbit polyclonal UCP2 antibody |
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UCP2 Antibody |
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| DF8626 | Affbiotech | 200ul | EUR 304 |
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Description: UCP2 Antibody detects endogenous levels of total UCP2. |
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UCP2 Antibody |
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| 1-CSB-PA060040 | Cusabio |
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|
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000 |
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UCP2 Antibody |
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| 1-CSB-PA299698 | Cusabio |
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|
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:10-1:50 |
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UCP2 Antibody |
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| 1-CSB-PA025555EA01HU | Cusabio |
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
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UCP2 Antibody |
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| 1-CSB-PA025555GA01HU | Cusabio |
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|
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
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UCP2 Antibody |
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| 1-CSB-PA032095 | Cusabio |
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100 |
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 UCP2 siRNA |
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| 20-abx938928 | Abbexa |
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UCP2 siRNA |
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| 20-abx938929 | Abbexa |
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UCP2 Antibody |
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| 40280-100ul | SAB | 100ul | EUR 252 |
UCP2 siRNA |
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| 20-abx905933 | Abbexa |
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 Mouse Lipin-1 Control/blocking peptide control/blocking peptide #1 |
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| LPN11-P | Alpha Diagnostics | 100 ug | EUR 164 |
 Mouse Lipin-2 Control/blocking peptide control/blocking peptide #1 |
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| LPN21-P | Alpha Diagnostics | 100 ug | EUR 164 |
 Mouse Lipin-3 Control/blocking peptide control/blocking peptide #1 |
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| LPN31-P | Alpha Diagnostics | 100 ug | EUR 164 |
C-Peptide Blocking Peptide |
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| 3277BP-50 | Biovision | EUR 153 | |
 CLDN6 Mouse mAb Blocking Peptide |
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| BF8001-BP | Affbiotech | 1mg | EUR 195 |
 Fibronectin Mouse mAb Blocking Peptide |
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| BF9010-BP | Affbiotech | 1mg | EUR 195 |
 HSP70 Mouse mAb Blocking Peptide |
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| BF9012-BP | Affbiotech | 1mg | EUR 195 |
) Angiopoietin 1 Blocking Peptide (Mouse) |
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| 30R-AA012 | Fitzgerald | 100 ug | EUR 256 |
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Description: A synthetic Angiopoietin 1 Blocking peptide for use as a blocking control in assays to test for specificity of Angiopoietin 1 antibody, catalog no. 70R-AR004 |
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) PPAR Delta Blocking Peptide (Mouse) |
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| 30R-AC025 | Fitzgerald | 50 ug | EUR 251 |
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Description: PPAR synthetic control neutralising peptide |
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 Mouse CYP1B1 control/blocking peptide |
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| CYP1B12-P | Alpha Diagnostics | 100 ug | EUR 164 |
 Mouse Agouti Control/blocking peptide |
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| AGO11-P | Alpha Diagnostics | 100 ug | EUR 164 |
 Mouse AQP12 control/blocking peptide |
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| AQP125-P | Alpha Diagnostics | 100 ug | EUR 152 |
 Mouse Klotho Control/blocking peptide |
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| KL11-P | Alpha Diagnostics | 100 ug | EUR 164 |
 Mouse Moesin control/blocking peptide |
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| MSN11-P | Alpha Diagnostics | 100 ug | EUR 164 |
 (pORF)) Ucp2 ORF Vector (Mouse) (pORF) |
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| ORF060984 | ABM | 1.0 ug DNA | EUR 506 |
 (OKEH05261)) UCP2 ELISA Kit (Mouse) (OKEH05261) |
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| OKEH05261 | Aviva Systems Biology | 96 Wells | EUR 662 |
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Description: Description of target: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.089 ng/mL |
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 (OKCD08189)) UCP2 ELISA Kit (Mouse) (OKCD08189) |
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| OKCD08189 | Aviva Systems Biology | 96 Wells | EUR 1001 |
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Description: Description of target: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 0.059ng/mL |
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 (OKAN05918)) UCP2 ELISA Kit (Mouse) (OKAN05918) |
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| OKAN05918 | Aviva Systems Biology | 96 Wells | EUR 792 |
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Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.059 ng/mL |
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 control/blocking peptide # 1) Mouse Peptide YY (PYY) control/blocking peptide # 1 |
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| PYY11-P | Alpha Diagnostics | 100 ug | EUR 164 |
ELNE Blocking Peptide |
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| AF0010-BP | Affbiotech | 1mg | EUR 195 |
ERLN2 Blocking Peptide |
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| AF0011-BP | Affbiotech | 1mg | EUR 195 |
CAPG Blocking Peptide |
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| AF0012-BP | Affbiotech | 1mg | EUR 195 |
CAPG Blocking Peptide |
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| AF0013-BP | Affbiotech | 1mg | EUR 195 |
CD28 Blocking Peptide |
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| AF0014-BP | Affbiotech | 1mg | EUR 195 |
RYR2 Blocking Peptide |
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| AF0015-BP | Affbiotech | 1mg | EUR 195 |
CD31 Blocking Peptide |
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| AF0077-BP | Affbiotech | 1mg | EUR 195 |
Bax Blocking Peptide |
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| AF0083-BP | Affbiotech | 1mg | EUR 195 |
hnRPD Blocking Peptide |
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| AF0092-BP | Affbiotech | 1mg | EUR 195 |
eNOS Blocking Peptide |
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| AF0096-BP | Affbiotech | 1mg | EUR 195 |
HSF1 Blocking Peptide |
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| AF0098-BP | Affbiotech | 1mg | EUR 195 |
TTK Blocking Peptide |
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| AF0102-BP | Affbiotech | 1mg | EUR 195 |
FRS2 Blocking Peptide |
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| AF0103-BP | Affbiotech | 1mg | EUR 195 |
Gab2 Blocking Peptide |
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| AF0106-BP | Affbiotech | 1mg | EUR 195 |
APLF Blocking Peptide |
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| AF0108-BP | Affbiotech | 1mg | EUR 195 |
RAD17 Blocking Peptide |
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| AF0110-BP | Affbiotech | 1mg | EUR 195 |
RON Blocking Peptide |
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| AF0111-BP | Affbiotech | 1mg | EUR 195 |
APAF1 Blocking Peptide |
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| AF0117-BP | Affbiotech | 1mg | EUR 195 |
ARC Blocking Peptide |
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| AF0118-BP | Affbiotech | 1mg | EUR 195 |
Bak Blocking Peptide |
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| AF0119-BP | Affbiotech | 1mg | EUR 195 |
Bax Blocking Peptide |
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| AF0120-BP | Affbiotech | 1mg | EUR 195 |
BIM Blocking Peptide |
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| AF0121-BP | Affbiotech | 1mg | EUR 195 |
CARD6 Blocking Peptide |
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| AF0123-BP | Affbiotech | 1mg | EUR 195 |
Fos Blocking Peptide |
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| AF0132-BP | Affbiotech | 1mg | EUR 195 |
Cox1 Blocking Peptide |
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| AF0138-BP | Affbiotech | 1mg | EUR 195 |
Desmin Blocking Peptide |
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| AF0147-BP | Affbiotech | 1mg | EUR 195 |
TFDP1 Blocking Peptide |
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| AF0149-BP | Affbiotech | 1mg | EUR 195 |
Dysferlin Blocking Peptide |
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| AF0150-BP | Affbiotech | 1mg | EUR 195 |
E2F4 Blocking Peptide |
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| AF0151-BP | Affbiotech | 1mg | EUR 195 |
E2F6 Blocking Peptide |
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| AF0152-BP | Affbiotech | 1mg | EUR 195 |
ERCC1 Blocking Peptide |
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| AF0154-BP | Affbiotech | 1mg | EUR 195 |
FASL Blocking Peptide |
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| AF0157-BP | Affbiotech | 1mg | EUR 195 |
FGFR2 Blocking Peptide |
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| AF0159-BP | Affbiotech | 1mg | EUR 195 |
FGFR3 Blocking Peptide |
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| AF0160-BP | Affbiotech | 1mg | EUR 195 |
FLI1 Blocking Peptide |
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| AF0161-BP | Affbiotech | 1mg | EUR 195 |
GABBR1 Blocking Peptide |
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| AF0162-BP | Affbiotech | 1mg | EUR 195 |
GAD1 Blocking Peptide |
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| AF0163-BP | Affbiotech | 1mg | EUR 195 |
GANP Blocking Peptide |
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| AF0165-BP | Affbiotech | 1mg | EUR 195 |
mGluR4 Blocking Peptide |
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| AF0168-BP | Affbiotech | 1mg | EUR 195 |
GluR5 Blocking Peptide |
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| AF0169-BP | Affbiotech | 1mg | EUR 195 |
mGluR6 Blocking Peptide |
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| AF0170-BP | Affbiotech | 1mg | EUR 195 |
mGluR7 Blocking Peptide |
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| AF0171-BP | Affbiotech | 1mg | EUR 195 |
mGluR8 Blocking Peptide |
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| AF0172-BP | Affbiotech | 1mg | EUR 195 |
GLUT1 Blocking Peptide |
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| AF0173-BP | Affbiotech | 1mg | EUR 195 |
GLUT3 Blocking Peptide |
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| AF0174-BP | Affbiotech | 1mg | EUR 195 |
GRP75 Blocking Peptide |
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| AF0176-BP | Affbiotech | 1mg | EUR 195 |
HDAC1 Blocking Peptide |
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| AF0178-BP | Affbiotech | 1mg | EUR 195 |
HDAC10 Blocking Peptide |
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| AF0179-BP | Affbiotech | 1mg | EUR 195 |
HDAC7 Blocking Peptide |
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| AF0180-BP | Affbiotech | 1mg | EUR 195 |
HDAC9 Blocking Peptide |
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| AF0181-BP | Affbiotech | 1mg | EUR 195 |
HSP10 Blocking Peptide |
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| AF0183-BP | Affbiotech | 1mg | EUR 195 |
HSP60 Blocking Peptide |
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| AF0184-BP | Affbiotech | 1mg | EUR 195 |
Involucrin Blocking Peptide |
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| AF0186-BP | Affbiotech | 1mg | EUR 195 |
COPS3 Blocking Peptide |
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| AF0187-BP | Affbiotech | 1mg | EUR 195 |
JM4 Blocking Peptide |
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| AF0188-BP | Affbiotech | 1mg | EUR 195 |
Ki67 Blocking Peptide |
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| AF0198-BP | Affbiotech | 1mg | EUR 195 |
iNOS Blocking Peptide |
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| AF0199-BP | Affbiotech | 1mg | EUR 195 |
Ku80 Blocking Peptide |
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| AF0200-BP | Affbiotech | 1mg | EUR 195 |
Ku70 Blocking Peptide |
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| AF0201-BP | Affbiotech | 1mg | EUR 195 |
Mammaglobin Blocking Peptide |
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| AF0202-BP | Affbiotech | 1mg | EUR 195 |
MLANA Blocking Peptide |
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| AF0204-BP | Affbiotech | 1mg | EUR 195 |
MCL1 Blocking Peptide |
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| AF0205-BP | Affbiotech | 1mg | EUR 195 |
MCM2 Blocking Peptide |
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| AF0206-BP | Affbiotech | 1mg | EUR 195 |
MCM5 Blocking Peptide |
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| AF0207-BP | Affbiotech | 1mg | EUR 195 |
MDM2 Blocking Peptide |
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| AF0208-BP | Affbiotech | 1mg | EUR 195 |
MMP1 Blocking Peptide |
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| AF0209-BP | Affbiotech | 1mg | EUR 195 |
MMP11 Blocking Peptide |
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| AF0211-BP | Affbiotech | 1mg | EUR 195 |
MMP14 Blocking Peptide |
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| AF0212-BP | Affbiotech | 1mg | EUR 195 |
MMP15 Blocking Peptide |
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| AF0213-BP | Affbiotech | 1mg | EUR 195 |
MMP16 Blocking Peptide |
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| AF0214-BP | Affbiotech | 1mg | EUR 195 |
MMP19 Blocking Peptide |
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| AF0215-BP | Affbiotech | 1mg | EUR 195 |
MMP23 Blocking Peptide |
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| AF0216-BP | Affbiotech | 1mg | EUR 195 |
MMP3 Blocking Peptide |
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| AF0217-BP | Affbiotech | 1mg | EUR 195 |
MMP7 Blocking Peptide |
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| AF0218-BP | Affbiotech | 1mg | EUR 195 |
MMP8 Blocking Peptide |
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| AF0219-BP | Affbiotech | 1mg | EUR 195 |
MMP9 Blocking Peptide |
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| AF0220-BP | Affbiotech | 1mg | EUR 195 |
NKX3.1 Blocking Peptide |
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| AF0221-BP | Affbiotech | 1mg | EUR 195 |
NM23 Blocking Peptide |
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| AF0222-BP | Affbiotech | 1mg | EUR 195 |
NSE Blocking Peptide |
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| AF0223-BP | Affbiotech | 1mg | EUR 195 |
OCT1 Blocking Peptide |
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| AF0224-BP | Affbiotech | 1mg | EUR 195 |
OCT2 Blocking Peptide |
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| AF0225-BP | Affbiotech | 1mg | EUR 195 |
OCT3 Blocking Peptide |
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| AF0226-BP | Affbiotech | 1mg | EUR 195 |
Osteopontin Blocking Peptide |
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| AF0227-BP | Affbiotech | 1mg | EUR 195 |
PCAF Blocking Peptide |
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| AF0231-BP | Affbiotech | 1mg | EUR 195 |
p63 Blocking Peptide |
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| AF0233-BP | Affbiotech | 1mg | EUR 195 |
Parkin Blocking Peptide |
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| AF0235-BP | Affbiotech | 1mg | EUR 195 |
Patched Blocking Peptide |
|||
| AF0237-BP | Affbiotech | 1mg | EUR 195 |
PCNA Blocking Peptide |
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| AF0239-BP | Affbiotech | 1mg | EUR 195 |
PDGFB Blocking Peptide |
|||
| AF0240-BP | Affbiotech | 1mg | EUR 195 |
PDGFRalpha Blocking Peptide |
|||
| AF0241-BP | Affbiotech | 1mg | EUR 195 |
Peripherin Blocking Peptide |
|||
| AF0242-BP | Affbiotech | 1mg | EUR 195 |
PGP9.5 Blocking Peptide |
|||
| AF0243-BP | Affbiotech | 1mg | EUR 195 |
KCNC2 Blocking Peptide |
|||
| AF0244-BP | Affbiotech | 1mg | EUR 195 |
KLK3 Blocking Peptide |
|||
| AF0246-BP | Affbiotech | 1mg | EUR 195 |
RCBTB1 Blocking Peptide |
|||
| AF0248-BP | Affbiotech | 1mg | EUR 195 |
RIT1 Blocking Peptide |
|||
| AF0250-BP | Affbiotech | 1mg | EUR 195 |
SHIP1 Blocking Peptide |
|||
| AF0252-BP | Affbiotech | 1mg | EUR 195 |
SHPS1 Blocking Peptide |
|||
| AF0253-BP | Affbiotech | 1mg | EUR 195 |
SNAP25 Blocking Peptide |
|||
| AF0254-BP | Affbiotech | 1mg | EUR 195 |
CSTB Blocking Peptide |
|||
| AF0256-BP | Affbiotech | 1mg | EUR 195 |
Synaptophysin Blocking Peptide |
|||
| AF0257-BP | Affbiotech | 1mg | EUR 195 |
TGFR2 Blocking Peptide |
|||
| AF0259-BP | Affbiotech | 1mg | EUR 195 |
TGFB3 Blocking Peptide |
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| AF0261-BP | Affbiotech | 1mg | EUR 195 |
TIMP2 Blocking Peptide |
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| AF0264-BP | Affbiotech | 1mg | EUR 195 |
TIMP3 Blocking Peptide |
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| AF0265-BP | Affbiotech | 1mg | EUR 195 |
AOS1 Blocking Peptide |
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| AF0266-BP | Affbiotech | 1mg | EUR 195 |
CDK7 Blocking Peptide |
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| AF0267-BP | Affbiotech | 1mg | EUR 195 |
EDD Blocking Peptide |
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| AF0268-BP | Affbiotech | 1mg | EUR 195 |
HAT Blocking Peptide |
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| AF0269-BP | Affbiotech | 1mg | EUR 195 |
NCoR1 Blocking Peptide |
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| AF0270-BP | Affbiotech | 1mg | EUR 195 |
NEDD8 Blocking Peptide |
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| AF0271-BP | Affbiotech | 1mg | EUR 195 |
NYREN18 Blocking Peptide |
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| AF0272-BP | Affbiotech | 1mg | EUR 195 |
PIAS2 Blocking Peptide |
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| AF0273-BP | Affbiotech | 1mg | EUR 195 |
PIAS3 Blocking Peptide |
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| AF0274-BP | Affbiotech | 1mg | EUR 195 |
SENP1 Blocking Peptide |
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| AF0275-BP | Affbiotech | 1mg | EUR 195 |
SENP5 Blocking Peptide |
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| AF0276-BP | Affbiotech | 1mg | EUR 195 |
SENP6 Blocking Peptide |
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| AF0277-BP | Affbiotech | 1mg | EUR 195 |
SENP7 Blocking Peptide |
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| AF0278-BP | Affbiotech | 1mg | EUR 195 |
SENP8 Blocking Peptide |
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| AF0279-BP | Affbiotech | 1mg | EUR 195 |
Sumo1 Blocking Peptide |
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| AF0280-BP | Affbiotech | 1mg | EUR 195 |
TIMP4 Blocking Peptide |
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| AF0281-BP | Affbiotech | 1mg | EUR 195 |
TNFR1 Blocking Peptide |
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| AF0282-BP | Affbiotech | 1mg | EUR 195 |
TOP2B Blocking Peptide |
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| AF0283-BP | Affbiotech | 1mg | EUR 195 |
TRADD Blocking Peptide |
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| AF0284-BP | Affbiotech | 1mg | EUR 195 |
Tyrosinase Blocking Peptide |
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| AF0286-BP | Affbiotech | 1mg | EUR 195 |