themoralbrain

Cellulaire veroudering bij hepatocellulair carcinoom

Cellulaire veroudering bij hepatocellulair carcinoom geïnduceerd door een lang niet-coderend RNA-gecodeerd peptide PINT87aa door FOXM1-gemedieerde PHB2 te blokkeren

Rationale:  Onlangs is aangetoond dat lange niet-coderende RNA’s (lncRNA’s), waarvan bekend is dat ze betrokken zijn bij de progressie van kanker bij de mens, coderen voor peptiden met biologische functies, maar de rol van door lncRNA gecodeerde peptiden bij cellulaire veroudering is grotendeels onontgonnen. We rapporteerden eerder de tumor-onderdrukkende rol van PINT87aa, een peptide dat wordt gecodeerd door het lange intergene niet-eiwit coderende RNA, p53-geïnduceerde transcript ( LINC-PINT).  Hier hebben we de rol van PINT87aa bij cellulaire senescentie van hepatocellulair carcinoom (HCC) onderzocht.

Methoden:  We onderzochten de functies van PINT87aa en afgeknotte PINT87aa  in vitro  door celproliferatie te volgen en voerden flowcytometrie uit, senescentie-geassocieerde β-galactosidase-kleuring, JC-1-kleuring die indicatief is voor mitochondriaal membraanpotentieel, de verhouding van het overlappende gebied van lichte keten Three bèta ( LC3B) en mitochondriale sondes en de verhouding van lysosomaal geassocieerd membraaneiwit 1 (LAMP1) overlapt met cytochroom c-oxidase-subeenheid 4I1 (COXIV) die mitofagie aangeeft. PINT87aa en afgeknotte PINT87aa-functies  in vivo werden geverifieerd door subcutaan getransplanteerde tumoren in naakte muizen. De mogelijke binding tussen PINT87aa en forkhead subject M1 (FOXM1) werd voorspeld door middel van structurele analyse en geverifieerd door co-immunoprecipitatie en immunofluorescentie co-lokalisatie. Rescue-experimenten werden  in vivo en in vitro uitgevoerd  na overexpressie van FOXM1. Verder werden chromatine-immunoprecipitatie, polymerasekettingreactie en dual-luciferase-reportergentest uitgevoerd om FOXM1-binding aan de prohibitine 2  ( PHB2 ) -promotor te valideren  .

Resultaten:  PINT87aa was necessary verhoogd in het door waterstofperoxide geïnduceerde HCC-celsenescentiemodel. Overexpressie van PINT87aa induceerde groeiremming, cellulaire veroudering en verminderde mitofagie  in vitro  en  in vivo . Daarentegen zou FOXM1 gain-of-function het aandeel senescente HCC-cellen gedeeltelijk kunnen verminderen en de mitofagie kunnen verbeteren. PINT87aa-overexpressie had geen invloed op de expressie van FOXM1 zelf, maar verminderde die van zijn doelwitgenen die betrokken zijn bij celcyclus en proliferatie, met establish  PHB2, die betrokken was bij mitofagie en getranscribeerd door FOXM1. Structurele analyse gaf aan dat PINT87aa kon binden aan het DNA-bindende domein van FOXM1, wat werd bevestigd door co-immunoprecipitatie en immunofluorescentie co-lokalisatie. Verder hebben we aangetoond dat de afgeknotte vorm van 2 tot 39 aminozuren van het peptide effecten uitoefende die vergelijkbaar waren met de volledige vorm.

Conclusie:  Onze studie stelde de rol enormous van PINT87aa als een nieuwe biomarker en een belangrijke regulator van cellulaire veroudering in HCC en identificeerde PINT87aa als een potentieel therapeutisch doelwit voor HCC.

themoralbrain
themoralbrain

 

 

 

 

 

 

 

 

UCP2 Blocking Peptide

DF8626-BP 1mg
EUR 234

UCP3 Blocking Peptide

DF6443-BP 1mg
EUR 234

UCP3 Blocking Peptide

20-abx161750
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Erythropoietin Mimetic Peptide Sequence 20

H-4344.0001 1.0mg
EUR 544.8
Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net

Erythropoietin Mimetic Peptide Sequence 20

H-4344.0005 5.0mg
EUR 2067.6
Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net

Substance P reversed sequence Peptide

20-abx266314
  • EUR 594.00
  • EUR 978.00
  • EUR 427.20
  • 10 mg
  • 25 mg
  • 5 mg

UCP2 Blocking Peptide (Mouse)

30R-AU001 100 ug
EUR 289.2
Description: A synthetic UCP2 Blocking peptide for use as a blocking control in assays to test for specificity of UCP2 antibody, catalog no. 20R-UR001

UCP3 C-terminal Blocking Peptide

30R-AU002 100 ug
EUR 289.2
Description: A synthetic UCP3 C-terminal Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 C-terminal antibody, catalog no. 70R-UR004

Rat Uncoupling Protein 3 (UCP3) Control/blocking peptide #3

UCP33-P 100 ug
EUR 196.8

Rat Uncoupling Protein 4 (UCP4) Control/blocking peptide #2

UCP42-P 100 ug
EUR 196.8

Borrelia Vmp-like sequence expressed (VlsE) C6 peptide (>90%) for ELISA

VLSE65-UL 100 ug
EUR 416.4

NET Blocking Peptide (Rat)

30R-AN036 100 ug
EUR 289.2
Description: A synthetic NET Blocking peptide for use as a blocking control in assays to test for specificity of NET antibody, catalog no. 70R-NR004

Mouse Uncoupling Protein 1 (UCP1) Control/blocking peptide # 1

UCP11-P 100 ug
EUR 196.8

Mouse Uncoupling Protein 1 (UCP1) Control/blocking peptide # 2

UCP12-P 100 ug
EUR 196.8

Mouse Uncoupling Protein 2 (UCP2) Control/blocking peptide #1

UCP21-P 100 ug
EUR 196.8

Mouse Uncoupling Protein 2 (UCP2) Control/blocking peptide #2

UCP22-P 100 ug
EUR 196.8

Human Uncoupling Protein 2 (UCP2) Control/blocking peptide #3

UCP23-P 100 ug
EUR 196.8

Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #1

UCP31-P 100 ug
EUR 196.8

Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #2

UCP32-P 100 ug
EUR 196.8

Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #4

UCP34-P 100 ug
EUR 196.8

Human Uncoupling Protein 4 (UCP4) Control/blocking peptide #1

UCP41-P 100 ug
EUR 196.8

Borrelia Vmp-like sequence expressed (VlsE) C6 peptide-Biotin (>90%) for ELISA

VLSE65-BTN 100 ug
EUR 489.6

Rat Calnuc Blocking Peptide

33R-2673 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NUCB1 antibody, catalog no. 70R-1118

Rabbit Anti-Borrelia Vmp-like sequence expressed (VlsE) C6 peptide IgG, aff pure

VLSE61-A 100 ul
EUR 578.4

Rat GTRAP41 Control/blocking peptide

GTRAP41-P 100 ug
EUR 196.8

Rat GTRAP48 Control/blocking peptide

GTRAP48-P 100 ug
EUR 196.8

40787 Blocking Peptide

33R-2900 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT1 antibody, catalog no. 70R-9926

hCG_1982709 Blocking Peptide

33R-3437 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1982709 antibody, catalog no. 70R-9054

hCG_2042202 Blocking Peptide

33R-3770 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2042202 antibody, catalog no. 70R-9063

hCG_1660138 Blocking Peptide

33R-4078 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1660138 antibody, catalog no. 70R-9044

hCG_1646157 Blocking Peptide

33R-4162 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9034

hCG_20426 Blocking Peptide

33R-4753 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8776

hCG_2007354 Blocking Peptide

33R-5366 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2007354 antibody, catalog no. 70R-9061

hCG_20426 Blocking Peptide

33R-5875 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8775

HCG_1745121 Blocking Peptide

33R-6558 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1745121 antibody, catalog no. 70R-3903

hCG_1646157 Blocking Peptide

33R-7420 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9035

TK Blocking Peptide

AF7678-BP 1mg
EUR 234

Rb Blocking Peptide

AF7698-BP 1mg
EUR 234

T Blocking Peptide

BF0015-BP 1mg
EUR 234

A1 Blocking Peptide

3401BP-50 each
EUR 183.6

Ub Blocking Peptide

20-abx063395
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

E7 Blocking Peptide

BF0311-BP 1mg
EUR 234

AR Blocking Peptide

BF0418-BP 1mg
EUR 234

PR Blocking Peptide

BF0581-BP 1mg
EUR 234

RB Blocking Peptide

BF0614-BP 1mg
EUR 234

ER Blocking Peptide

BF0674-BP 1mg
EUR 234

GK Blocking Peptide

AF0829-BP 1mg
EUR 234

GR Blocking Peptide

AF5004-BP 1mg
EUR 234

GR Blocking Peptide

AF6066-BP 1mg
EUR 234

GR Blocking Peptide

AF6067-BP 1mg
EUR 234

TK Blocking Peptide

AF6068-BP 1mg
EUR 234

IR Blocking Peptide

AF6098-BP 1mg
EUR 234

IR Blocking Peptide

AF6099-BP 1mg
EUR 234

F7 Blocking Peptide

33R-1026 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DLG4 antibody, catalog no. 70R-4080

GC Blocking Peptide

33R-10350 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10252

A1 Blocking Peptide

33R-10744 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of A1 antibody, catalog no. 70R-11802

KC Blocking Peptide

33R-11041 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KC antibody, catalog no. 70R-12298

F2 Blocking Peptide

33R-1783 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F2 antibody, catalog no. 70R-8514

PB Blocking Peptide

33R-2067 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of pb antibody, catalog no. 70R-2192

AC Blocking Peptide

33R-3003 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ac antibody, catalog no. 70R-1978

XK Blocking Peptide

33R-7655 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7274

F7 Blocking Peptide

33R-7835 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F7 antibody, catalog no. 70R-9970

PC Blocking Peptide

33R-8614 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PC antibody, catalog no. 70R-9828

TH Blocking Peptide

33R-3167 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-7854

F8 Blocking Peptide

33R-3569 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F8 antibody, catalog no. 70R-9971

NP Blocking Peptide

33R-3631 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NP antibody, catalog no. 70R-2286

GC Blocking Peptide

33R-4418 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10253

XK Blocking Peptide

33R-5017 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7169

SI Blocking Peptide

33R-5258 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7230

GK Blocking Peptide

33R-5595 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GK antibody, catalog no. 70R-4533

TH Blocking Peptide

33R-6309 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-10442

HB Blocking Peptide

33R-6336 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hb antibody, catalog no. 70R-3198

N Blocking Peptide

33R-6561 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LSM8 antibody, catalog no. 70R-4590

SI Blocking Peptide

33R-6891 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7205

KC Blocking Peptide

5212BP-50 each
EUR 183.6

OR Blocking Peptide

DF10250-BP 1mg
EUR 234

CP Blocking Peptide

DF9369-BP 1mg
EUR 234

C7 Blocking Peptide

DF9410-BP 1mg
EUR 234

MB Blocking Peptide

DF7358-BP 1mg
EUR 234

FH Blocking Peptide

DF7460-BP 1mg
EUR 234

AR Blocking Peptide

DF6783-BP 1mg
EUR 234

C5 Blocking Peptide

DF7719-BP 1mg
EUR 234

GC Blocking Peptide

DF7840-BP 1mg
EUR 234

TG Blocking Peptide

DF7885-BP 1mg
EUR 234

F5 Blocking Peptide

DF8265-BP 1mg
EUR 234

Ob Blocking Peptide

DF8583-BP 1mg
EUR 234

ST Blocking Peptide

DF8616-BP 1mg
EUR 234

C6 Blocking Peptide

DF3963-BP 1mg
EUR 234

C9 Blocking Peptide

DF3964-BP 1mg
EUR 234

MB Blocking Peptide

DF4194-BP 1mg
EUR 234

NT Blocking Peptide

DF4245-BP 1mg
EUR 234

PC Blocking Peptide

DF4364-BP 1mg
EUR 234

F3 Blocking Peptide

DF6400-BP 1mg
EUR 234

HP Blocking Peptide

DF6467-BP 1mg
EUR 234

F9 Blocking Peptide

DF6474-BP 1mg
EUR 234

GK Blocking Peptide

DF3151-BP 1mg
EUR 234

FX Blocking Peptide

20-abx161511
  • EUR 727.20
  • EUR 1713.60
  • 1 mg
  • 5 mg

GW Blocking Peptide

20-abx162574
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Rat UT2 Control/blocking peptide #1

RUT21-P 100 ug
EUR 196.8

PEPT1 Blocking Peptide

20-abx063272
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

SKI Blocking Peptide

AF7536-BP 1mg
EUR 234

EED Blocking Peptide

AF7558-BP 1mg
EUR 234

TXN Blocking Peptide

AF7577-BP 1mg
EUR 234

Bim Blocking Peptide

AF7620-BP 1mg
EUR 234

Bim Blocking Peptide

AF7621-BP 1mg
EUR 234

LAT Blocking Peptide

AF7625-BP 1mg
EUR 234

LAT Blocking Peptide

AF7626-BP 1mg
EUR 234

DR6 Blocking Peptide

AF7652-BP 1mg
EUR 234

PZR Blocking Peptide

AF7665-BP 1mg
EUR 234

PZR Blocking Peptide

AF7666-BP 1mg
EUR 234

PZR Blocking Peptide

AF7667-BP 1mg
EUR 234

Myc Blocking Peptide

AF7674-BP 1mg
EUR 234

p53 Blocking Peptide

AF7685-BP 1mg
EUR 234

p53 Blocking Peptide

AF7686-BP 1mg
EUR 234

APP Blocking Peptide

AF7687-BP 1mg
EUR 234

Lck Blocking Peptide

AF7694-BP 1mg
EUR 234

Lck Blocking Peptide

AF7695-BP 1mg
EUR 234

LCK Blocking Peptide

AF7696-BP 1mg
EUR 234

Fyn Blocking Peptide

AF7697-BP 1mg
EUR 234

NPM Blocking Peptide

AF7703-BP 1mg
EUR 234

Lyn Blocking Peptide

AF7708-BP 1mg
EUR 234

HCK Blocking Peptide

AF7711-BP 1mg
EUR 234

Bcr Blocking Peptide

AF7715-BP 1mg
EUR 234

Bcr Blocking Peptide

AF7716-BP 1mg
EUR 234

HS1 Blocking Peptide

AF7726-BP 1mg
EUR 234

FER Blocking Peptide

AF7737-BP 1mg
EUR 234

UBF Blocking Peptide

AF7743-BP 1mg
EUR 234

MAK Blocking Peptide

AF7757-BP 1mg
EUR 234

CBL Blocking Peptide

AF7763-BP 1mg
EUR 234

AXL Blocking Peptide

AF7793-BP 1mg
EUR 234

YB1 Blocking Peptide

AF7832-BP 1mg
EUR 234

YB1 Blocking Peptide

AF7833-BP 1mg
EUR 234

BTK Blocking Peptide

AF7854-BP 1mg
EUR 234

BTK Blocking Peptide

AF7855-BP 1mg
EUR 234

SF1 Blocking Peptide

AF7895-BP 1mg
EUR 234

Bad Blocking Peptide

AF7927-BP 1mg
EUR 234

AT2 Blocking Peptide

30R-AA024 100 ug
EUR 289.2
Description: A synthetic AT2 Blocking peptide for use as a blocking control in assays to test for specificity of AT2 antibody, catalog no. 70R-AR006

PKA Blocking Peptide

3115BP-50 each
EUR 183.6

Bax Blocking Peptide

3032BP-50 each
EUR 183.6

p53 Blocking Peptide

3036RBP-50 each
EUR 183.6

PBR Blocking Peptide

3044BP-50 each
EUR 183.6

DR4 Blocking Peptide

3061BP-50 each
EUR 183.6

DR5 Blocking Peptide

3062BP-50 each
EUR 183.6

PPY Blocking Peptide

BF0012-BP 1mg
EUR 234

ILK Blocking Peptide

BF0030-BP 1mg
EUR 234

CD5 Blocking Peptide

BF0031-BP 1mg
EUR 234

SRY Blocking Peptide

BF0037-BP 1mg
EUR 234

SST Blocking Peptide

BF0042-BP 1mg
EUR 234

CD6 Blocking Peptide

BF0044-BP 1mg
EUR 234

EGF Blocking Peptide

BF0066-BP 1mg
EUR 234

KDR Blocking Peptide

BF0068-BP 1mg
EUR 234

AGT Blocking Peptide

BF0069-BP 1mg
EUR 234

SYK Blocking Peptide

BF0074-BP 1mg
EUR 234

FER Blocking Peptide

BF0076-BP 1mg
EUR 234

LAL Blocking Peptide

BF0079-BP 1mg
EUR 234

DCX Blocking Peptide

BF0083-BP 1mg
EUR 234

CRK Blocking Peptide

BF0088-BP 1mg
EUR 234

CEA Blocking Peptide

BF0092-BP 1mg
EUR 234

TEC Blocking Peptide

BF0100-BP 1mg
EUR 234

AAT Blocking Peptide

BF0101-BP 1mg
EUR 234

FOS Blocking Peptide

BF0115-BP 1mg
EUR 234

CRP Blocking Peptide

BF0116-BP 1mg
EUR 234

BLK Blocking Peptide

BF0124-BP 1mg
EUR 234

HK1 Blocking Peptide

BF0126-BP 1mg
EUR 234

PGR Blocking Peptide

BF0135-BP 1mg
EUR 234

FRK Blocking Peptide

BF0136-BP 1mg
EUR 234

Biocide werkzaamheid van tutine en de invloed ervan op immuuncellen en expressie van groeiremmende en neurogliale peptiden in Mythimna separata (Lepidoptera: Noctuidae)

Mythimna separata Walker (Lepidoptera: Noctuidae) is een van de belangrijkste plagen die ernstige schade aan graangewassen kan veroorzaken. De ontwikkeling van botanische insecticiden met een lage toxiciteit en hoge prestaties wordt de focus van nieuw onderzoek naar pesticiden om M. separata te bestrijden. Tutin, een sesquiterpeenlactonverbinding die wordt verkregen uit Coriaria sinica Maxim, een inheemse Chinese language language giftige plant, heeft een antivoedingsmiddel, absorptie en maagvergiftiging tegen een verscheidenheid aan plagen. Om het toxische impression van tutine op de larven van M. separata te begrijpen, wilden we hun anti-voedingsmiddel, mortaliteit, verlamming, gewichtsverandering bepalen en de verspreiding van M. separata hemocyten onder verschillende concentraties van tutinebehandeling onderzoeken.

Weefselverdeling van het immuun-geassocieerde gengroei-blokkerende peptide (GBP) en neuroglian peptide (Nrg) werd gedetecteerd door reverse transcriptie polymerase kettingreactie (PCR). Verder werd real-time kwantitatieve PCR uitgevoerd om de expressieprofielen van GBP en Nrg te bepalen na verschillende concentraties van tutine-stimulatie. Onze resultaten onthulden dat tutine significante anti-feedant en insecticide activiteiten, verlamming, gewichtsverlies voor M. separata vertoonde . Bovendien had tutine een significante invloed op de morfologie van hemocyten en versterkte het de expressie van GBP en Nrg in M. separata.

Van stress afgeleide reactieve zuurstofsoorten stellen hemocyten in staat om activator van groeiblokkerend peptide (GBP) -verwerkingsenzym af te geven

Insectencytokinegroeiblokkerend peptide (GBP) wordt gesynthetiseerd als een inactieve voorloper, proGBP genaamd, die normaal in een significante concentratie aanwezig is in de hemolymfe van dieren zonder stress (Hayakawa, 1990, 1991). Onder stressomstandigheden wordt proGBP onmiddellijk omgezet tot actief GBP door een serineprotease en males denkt dat dit een belangrijke eerste stap is voor insecten om het hoofd te bieden aan door stress veroorzaakte nadelige effecten by the use of GBP-geïnduceerde fysiologische veranderingen.

Het gedetailleerde mechanisme dat ten grondslag ligt aan de proteolytische verwerking van hemolymfe proGBP bij insecten onder stressomstandigheden blijft echter onbekend. Hier hebben we aangetoond dat proGBP-verwerking door ROS geïnduceerde afgifte van een eiwitachtige concern uit hemocyten vereist die het inactieve proGBP-verwerkingsenzym activeert. De afgifte van het activatoreiwit uit hemocyten wordt geïnitieerd door een verhoging van de cytoplasmatische Ca2 +  -concentratie, geïnduceerd door ROS. Daarom concludeerden we dat door stress geïnduceerde activering van proGBP ROS-afhankelijke stimulatie van een intracellulaire calciumsignaleringsroute in hemocyten vereist, gevolgd door afgifte van de hemocyt-eiwitachtige concern die specifiek het proGBP-verwerkingsenzym activeert.

Lipopolysacharide beïnvloedt het plasma en hersenen farmacokinetiek van subcutaan toegediende HsTX1 [R14a], Okay  V  1,3-blokkerende peptide

Okay<sub>V</sub>1.Three is een spanningsafhankelijk kaliumkanaal dat wordt opgereguleerd bij neuro-inflammatoire aandoeningen, zoals de ziekte van Alzheimer en de ziekte van Parkinson. HsTX1[R14A] is een krachtige en selectieve peptideblokker van Okay<sub>V</sub>1.Three met het potentieel om microgliale Okay<sub>V</sub>1.Three te blokkeren, maar de opname in de hersenen zal naar verwachting beperkt zijn vanwege de beperkende aard van de bloed-hersenbarrière. Om de perifere en hersenblootstelling te beoordelen , werd een LC-MS/MS-assay ontwikkeld om HsTX1[R14A]-concentraties in muizenplasma en hersenhomogenaat te kwantificeren die betrouwbaar en reproduceerbaar waren in het bereik van 6,7-66,7 nM (r<sup>2< /sup> = 0,9765) en 15-150 pmol/g (r<sup>2</sup> = 0,9984), respectievelijk.

Om te beoordelen of neuro-inflammatie de HsTX1[R14A]-dispositie beïnvloedde, kregen C57BL/6-muizen HsTX1[R14A] subcutaan (2 mg/kg) 24 uur na een intraperitoneale dosis Escherichia coli lipopolysaccharide (LPS), die vaak wordt gebruikt om neuro-inflammatie te induceren; hersen- en plasmaconcentraties van HsTX1[R14A] werden vervolgens gedurende 120 minuten gekwantificeerd. LPS-behandelingvertraagde de daling van de HsTX1[R14A]-plasmaconcentraties aanzienlijk, vermoedelijk als gevolg van een verminderde renale klaring, en leidde tot een substantiële opname van HsTX1[R14A] in de hersenen, vermoedelijk door verstoring van de inter-endotheliale tight junctions in de hersenen. Deze studie suggereert dat HsTX1[R14A] microglia kan bereiken in voldoende concentraties om Okay<sub>V</sub>1.Three te blokkeren bij neuro-inflammatoire aandoeningen, en daarom het potentieel heeft om neurodegeneratieve ziekten te verminderen.

UCP3 Blocking Peptide

30R-AU006 100 ug
EUR 289.2
Description: A synthetic UCP3 Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 antibody, catalog no. 20R-UR003

UCP1 Blocking Peptide

DF7720-BP 1mg
EUR 234

UCP3 Blocking Peptide

DF6443-BP 1mg
EUR 234

UCP3 Blocking Peptide

20-abx161750
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Human Uncoupling Protein 2 (UCP2) Control/blocking peptide #3

UCP23-P 100 ug
EUR 196.8

Erythropoietin Mimetic Peptide Sequence 20

H-4344.0001 1.0mg
EUR 544.8
Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net

Erythropoietin Mimetic Peptide Sequence 20

H-4344.0005 5.0mg
EUR 2067.6
Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net

UCP3 Blocking Peptide (Rat)

30R-AU003 100 ug
EUR 307.2
Description: A synthetic UCP3 Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 antibody, catalog no. 70R-UR005

UCP5 Blocking Peptide (Rat)

30R-AU004 100 ug
EUR 262.8
Description: A synthetic UCP5 peptide for use as a blocking control in assays to test for specificity of UCP5 antibody, catalog no. 20R-UR002

Substance P reversed sequence Peptide

20-abx266314
  • EUR 594.00
  • EUR 978.00
  • EUR 427.20
  • 10 mg
  • 25 mg
  • 5 mg

Mouse Uncoupling Protein 1 (UCP1) Control/blocking peptide # 1

UCP11-P 100 ug
EUR 196.8

Mouse Uncoupling Protein 1 (UCP1) Control/blocking peptide # 2

UCP12-P 100 ug
EUR 196.8

UCP3 C-terminal Blocking Peptide

30R-AU002 100 ug
EUR 289.2
Description: A synthetic UCP3 C-terminal Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 C-terminal antibody, catalog no. 70R-UR004

Mouse Lipin-1 Control/blocking peptide control/blocking peptide #1

LPN11-P 100 ug
EUR 196.8

Mouse Lipin-2 Control/blocking peptide control/blocking peptide #1

LPN21-P 100 ug
EUR 196.8

Mouse Lipin-3 Control/blocking peptide control/blocking peptide #1

LPN31-P 100 ug
EUR 196.8

GLUT4 Blocking peptide (Mouse)

30R-AG010 100 ug
EUR 289.2
Description: A synthetic GLUT4 Blocking peptide for use as a blocking control in assays to test for specificity of GLUT4 antibody, catalog no. 70R-GR014

GLUT8 Blocking Peptide (Mouse)

30R-AG011 100 ug
EUR 289.2
Description: A synthetic GLUT8 Blocking peptide for use as a blocking control in assays to test for specificity of GLUT8 antibody, catalog no. 70R-GR008

mouse Splunc2 Blocking Peptide

BF0461-BP 1mg
EUR 234

Borrelia Vmp-like sequence expressed (VlsE) C6 peptide (>90%) for ELISA

VLSE65-UL 100 ug
EUR 416.4

Mouse Peptide YY (PYY) control/blocking peptide # 1

PYY11-P 100 ug
EUR 196.8

CLDN6 Mouse mAb Blocking Peptide

BF8001-BP 1mg
EUR 234

HSP70 Mouse mAb Blocking Peptide

BF9012-BP 1mg
EUR 234

PPAR Delta Blocking Peptide (Mouse)

30R-AC025 50 ug
EUR 301.2
Description: PPAR synthetic control neutralising peptide

Rat Uncoupling Protein 3 (UCP3) Control/blocking peptide #3

UCP33-P 100 ug
EUR 196.8

Rat Uncoupling Protein 4 (UCP4) Control/blocking peptide #2

UCP42-P 100 ug
EUR 196.8

Rat Uncoupling Protein 5 (UCP5) Control/blocking peptide #1

UCP51-P 100 ug
EUR 196.8

Mouse AQP12 control/blocking peptide

AQP125-P 100 ug
EUR 182.4

Mouse Agouti Control/blocking peptide

AGO11-P 100 ug
EUR 196.8

Mouse CYP1B1 control/blocking peptide

CYP1B12-P 100 ug
EUR 196.8

Mouse Moesin control/blocking peptide

MSN11-P 100 ug
EUR 196.8

Mouse Klotho Control/blocking peptide

KL11-P 100 ug
EUR 196.8

Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #1

UCP31-P 100 ug
EUR 196.8

Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #2

UCP32-P 100 ug
EUR 196.8

Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #4

UCP34-P 100 ug
EUR 196.8

Human Uncoupling Protein 4 (UCP4) Control/blocking peptide #1

UCP41-P 100 ug
EUR 196.8

Human Uncoupling Protein 5 (UCP5) Control/blocking peptide #2

UCP52-P 100 ug
EUR 196.8

Angiopoietin 1 Blocking Peptide (Mouse)

30R-AA012 100 ug
EUR 307.2
Description: A synthetic Angiopoietin 1 Blocking peptide for use as a blocking control in assays to test for specificity of Angiopoietin 1 antibody, catalog no. 70R-AR004

Fibronectin Mouse mAb Blocking Peptide

BF9010-BP 1mg
EUR 234

Borrelia Vmp-like sequence expressed (VlsE) C6 peptide-Biotin (>90%) for ELISA

VLSE65-BTN 100 ug
EUR 489.6

HIF1 alpha Mouse mAb Blocking Peptide

BF8002-BP 1mg
EUR 234

Control/Blocking peptide Mouse BCL-2

BCL21-C 100 ug
EUR 196.8

Mouse Aven Control/blocking peptide # 2

AVEN12-P 100 ug
EUR 196.8

Mouse Per1 Control/blocking peptide #1

PER11-P 100 ug
EUR 196.8

Mouse Per2 Control/blocking peptide #1

PER21-P 100 ug
EUR 196.8

Mouse Per3 Control/blocking peptide #1

PER31-P 100 ug
EUR 196.8

Collagen III Mouse mAb Blocking Peptide

BF9208-BP 1mg
EUR 234

Mouse Clock Control/blocking peptide # 1

CLO11-P 100 ug
EUR 196.8

Mouse Leptin Control/blocking peptide # 1

OB11-P 100 ug
EUR 196.8

Mouse Leptin Control/blocking peptide # 2

OB12-P 100 ug
EUR 196.8

Rabbit Anti-Borrelia Vmp-like sequence expressed (VlsE) C6 peptide IgG, aff pure

VLSE61-A 100 ul
EUR 578.4

ErbB-2/HER2 Mouse mAb Blocking Peptide

BF9201-BP 1mg
EUR 234

Mouse/Human AQP11 control/blocking peptide

AQP115-P 100 ug
EUR 182.4

alpha-tubulin Mouse mAb Blocking Peptide

BF9210-BP 1mg
EUR 234

Mouse Meckelin (Mks3) Control/blocking peptide

AB-23268-P 100ug
EUR 196.8

Mouse Hephaestin (Hp) control/blocking peptide

HEPH11-P 100 ug
EUR 196.8

Mouse Vasoactive intestinal peptide (VIP) Control/blocking peptide #1

VIP16-P 100 ug
EUR 196.8

Mouse Neprilysin (NEP) Control/blocking peptide

NEP11-P 100 ug
EUR 196.8

Mouse Merlin 2 Control/blocking peptide #1

MERL21-P 100 ug
EUR 196.8

Mouse PiT1 (GLVR1) Control/blocking peptide #1

PIT11-P 100 ug
EUR 196.8

Mouse Orexin-B Control/blocking peptide # 1

OXB11-P 100 ug
EUR 196.8

Mouse dermatopontin (Dpt) Control/blocking peptide

AB-23026-P 100ug
EUR 196.8

Mouse p/CIP/p300 Control/blocking peptide # 1

CIP11-P 100 ug
EUR 196.8

Mouse p/CIP/p300 Control/blocking peptide # 2

CIP12-P 100 ug
EUR 196.8

Mouse Annexin A3 (Anxa3) Control/Blocking peptide

ANX311-P 100 ug
EUR 196.8

Mouse Neuromedin U control/blocking peptide # 4

NMU71-P 100 ug
EUR 196.8

Control/Blocking peptide for Mouse Vimentin (Vim)

VIM11-C 100 ug
EUR 196.8

Mouse Tubby Protein Control/blocking peptide # 1

TUBBY11-P 100 ug
EUR 196.8

40787 Blocking Peptide

33R-2900 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT1 antibody, catalog no. 70R-9926

hCG_1982709 Blocking Peptide

33R-3437 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1982709 antibody, catalog no. 70R-9054

hCG_2042202 Blocking Peptide

33R-3770 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2042202 antibody, catalog no. 70R-9063

hCG_1660138 Blocking Peptide

33R-4078 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1660138 antibody, catalog no. 70R-9044

hCG_1646157 Blocking Peptide

33R-4162 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9034

hCG_20426 Blocking Peptide

33R-4753 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8776

hCG_2007354 Blocking Peptide

33R-5366 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2007354 antibody, catalog no. 70R-9061

hCG_20426 Blocking Peptide

33R-5875 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8775

HCG_1745121 Blocking Peptide

33R-6558 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1745121 antibody, catalog no. 70R-3903

hCG_1646157 Blocking Peptide

33R-7420 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9035

TK Blocking Peptide

AF7678-BP 1mg
EUR 234

Rb Blocking Peptide

AF7698-BP 1mg
EUR 234

T Blocking Peptide

BF0015-BP 1mg
EUR 234

A1 Blocking Peptide

3401BP-50 each
EUR 183.6

Ub Blocking Peptide

20-abx063395
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

E7 Blocking Peptide

BF0311-BP 1mg
EUR 234

AR Blocking Peptide

BF0418-BP 1mg
EUR 234

PR Blocking Peptide

BF0581-BP 1mg
EUR 234

RB Blocking Peptide

BF0614-BP 1mg
EUR 234

ER Blocking Peptide

BF0674-BP 1mg
EUR 234

GK Blocking Peptide

AF0829-BP 1mg
EUR 234

GR Blocking Peptide

AF5004-BP 1mg
EUR 234

GR Blocking Peptide

AF6066-BP 1mg
EUR 234

GR Blocking Peptide

AF6067-BP 1mg
EUR 234

TK Blocking Peptide

AF6068-BP 1mg
EUR 234

IR Blocking Peptide

AF6098-BP 1mg
EUR 234

IR Blocking Peptide

AF6099-BP 1mg
EUR 234

F7 Blocking Peptide

33R-1026 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DLG4 antibody, catalog no. 70R-4080

GC Blocking Peptide

33R-10350 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10252

A1 Blocking Peptide

33R-10744 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of A1 antibody, catalog no. 70R-11802

KC Blocking Peptide

33R-11041 50 ug
EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KC antibody, catalog no. 70R-12298

F2 Blocking Peptide

33R-1783 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F2 antibody, catalog no. 70R-8514

PB Blocking Peptide

33R-2067 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of pb antibody, catalog no. 70R-2192

AC Blocking Peptide

33R-3003 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ac antibody, catalog no. 70R-1978

XK Blocking Peptide

33R-7655 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7274

F7 Blocking Peptide

33R-7835 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F7 antibody, catalog no. 70R-9970

PC Blocking Peptide

33R-8614 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PC antibody, catalog no. 70R-9828

TH Blocking Peptide

33R-3167 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-7854

F8 Blocking Peptide

33R-3569 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F8 antibody, catalog no. 70R-9971

NP Blocking Peptide

33R-3631 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NP antibody, catalog no. 70R-2286

GC Blocking Peptide

33R-4418 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10253

XK Blocking Peptide

33R-5017 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7169

SI Blocking Peptide

33R-5258 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7230

GK Blocking Peptide

33R-5595 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GK antibody, catalog no. 70R-4533

TH Blocking Peptide

33R-6309 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-10442

HB Blocking Peptide

33R-6336 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hb antibody, catalog no. 70R-3198

N Blocking Peptide

33R-6561 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LSM8 antibody, catalog no. 70R-4590

SI Blocking Peptide

33R-6891 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7205

KC Blocking Peptide

5212BP-50 each
EUR 183.6

OR Blocking Peptide

DF10250-BP 1mg
EUR 234

CP Blocking Peptide

DF9369-BP 1mg
EUR 234

C7 Blocking Peptide

DF9410-BP 1mg
EUR 234

MB Blocking Peptide

DF7358-BP 1mg
EUR 234

FH Blocking Peptide

DF7460-BP 1mg
EUR 234

AR Blocking Peptide

DF6783-BP 1mg
EUR 234

C5 Blocking Peptide

DF7719-BP 1mg
EUR 234

GC Blocking Peptide

DF7840-BP 1mg
EUR 234

TG Blocking Peptide

DF7885-BP 1mg
EUR 234

F5 Blocking Peptide

DF8265-BP 1mg
EUR 234

Ob Blocking Peptide

DF8583-BP 1mg
EUR 234

ST Blocking Peptide

DF8616-BP 1mg
EUR 234

C6 Blocking Peptide

DF3963-BP 1mg
EUR 234

C9 Blocking Peptide

DF3964-BP 1mg
EUR 234

MB Blocking Peptide

DF4194-BP 1mg
EUR 234

NT Blocking Peptide

DF4245-BP 1mg
EUR 234

PC Blocking Peptide

DF4364-BP 1mg
EUR 234

F3 Blocking Peptide

DF6400-BP 1mg
EUR 234

HP Blocking Peptide

DF6467-BP 1mg
EUR 234

F9 Blocking Peptide

DF6474-BP 1mg
EUR 234

GK Blocking Peptide

DF3151-BP 1mg
EUR 234

FX Blocking Peptide

20-abx161511
  • EUR 727.20
  • EUR 1713.60
  • 1 mg
  • 5 mg

GW Blocking Peptide

20-abx162574
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

Mouse pannexin 3 (Panx3) Control/blocking peptide

AB-23242-P 100ug
EUR 196.8

Mouse pannexin 3 (Panx3) Control/blocking peptide

AB-23243-P 100ug
EUR 196.8

Mouse pannexin 3 (Panx3) Control/blocking peptide

AB-23244-P 100ug
EUR 196.8

Mouse pannexin 1 (Panx1) Control/blocking peptide

AB-23246-P 100ug
EUR 196.8

Mouse pannexin 1 (Panx1) Control/blocking peptide

AB-23247-P 100ug
EUR 196.8

Mouse pannexin 2 (Panx2) Control/blocking peptide

AB-23260-P 100ug
EUR 196.8

Mouse aquaporin 2 (AQP2) Control/blocking peptide

AB-23265-P 100ug
EUR 196.8

Mouse pannexin 1 (Panx1) Control/blocking peptide

AB-23016-P 100ug
EUR 196.8

Mouse/Human Mahogany Control/blocking peptide #1

MAHG11-P 100 ug
EUR 196.8

PEPT1 Blocking Peptide

20-abx063272
  • EUR 326.40
  • EUR 493.20
  • 1 mg
  • 5 mg

SKI Blocking Peptide

AF7536-BP 1mg
EUR 234

EED Blocking Peptide

AF7558-BP 1mg
EUR 234

TXN Blocking Peptide

AF7577-BP 1mg
EUR 234

Bim Blocking Peptide

AF7620-BP 1mg
EUR 234

Bim Blocking Peptide

AF7621-BP 1mg
EUR 234

LAT Blocking Peptide

AF7625-BP 1mg
EUR 234

LAT Blocking Peptide

AF7626-BP 1mg
EUR 234

DR6 Blocking Peptide

AF7652-BP 1mg
EUR 234

PZR Blocking Peptide

AF7665-BP 1mg
EUR 234

PZR Blocking Peptide

AF7666-BP 1mg
EUR 234

PZR Blocking Peptide

AF7667-BP 1mg
EUR 234

Myc Blocking Peptide

AF7674-BP 1mg
EUR 234

p53 Blocking Peptide

AF7685-BP 1mg
EUR 234

p53 Blocking Peptide

AF7686-BP 1mg
EUR 234

APP Blocking Peptide

AF7687-BP 1mg
EUR 234

Lck Blocking Peptide

AF7694-BP 1mg
EUR 234

Lck Blocking Peptide

AF7695-BP 1mg
EUR 234

LCK Blocking Peptide

AF7696-BP 1mg
EUR 234

Fyn Blocking Peptide

AF7697-BP 1mg
EUR 234

NPM Blocking Peptide

AF7703-BP 1mg
EUR 234

Lyn Blocking Peptide

AF7708-BP 1mg
EUR 234

HCK Blocking Peptide

AF7711-BP 1mg
EUR 234

Bcr Blocking Peptide

AF7715-BP 1mg
EUR 234

Bcr Blocking Peptide

AF7716-BP 1mg
EUR 234

HS1 Blocking Peptide

AF7726-BP 1mg
EUR 234

FER Blocking Peptide

AF7737-BP 1mg
EUR 234

UBF Blocking Peptide

AF7743-BP 1mg
EUR 234

MAK Blocking Peptide

AF7757-BP 1mg
EUR 234

CBL Blocking Peptide

AF7763-BP 1mg
EUR 234

AXL Blocking Peptide

AF7793-BP 1mg
EUR 234

YB1 Blocking Peptide

AF7832-BP 1mg
EUR 234

YB1 Blocking Peptide

AF7833-BP 1mg
EUR 234

BTK Blocking Peptide

AF7854-BP 1mg
EUR 234

BTK Blocking Peptide

AF7855-BP 1mg
EUR 234

SF1 Blocking Peptide

AF7895-BP 1mg
EUR 234

Bad Blocking Peptide

AF7927-BP 1mg
EUR 234

AT2 Blocking Peptide

30R-AA024 100 ug
EUR 289.2
Description: A synthetic AT2 Blocking peptide for use as a blocking control in assays to test for specificity of AT2 antibody, catalog no. 70R-AR006

PKA Blocking Peptide

3115BP-50 each
EUR 183.6

Bax Blocking Peptide

3032BP-50 each
EUR 183.6

p53 Blocking Peptide

3036RBP-50 each
EUR 183.6

PBR Blocking Peptide

3044BP-50 each
EUR 183.6

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