Cellulaire veroudering bij hepatocellulair carcinoom geïnduceerd door een lang niet-coderend RNA-gecodeerd peptide PINT87aa door FOXM1-gemedieerde PHB2 te blokkeren
Rationale: Onlangs is aangetoond dat lange niet-coderende RNA’s (lncRNA’s), waarvan bekend is dat ze betrokken zijn bij de progressie van kanker bij de mens, coderen voor peptiden met biologische functies, maar de rol van door lncRNA gecodeerde peptiden bij cellulaire veroudering is grotendeels onontgonnen. We rapporteerden eerder de tumor-onderdrukkende rol van PINT87aa, een peptide dat wordt gecodeerd door het lange intergene niet-eiwit coderende RNA, p53-geïnduceerde transcript ( LINC-PINT). Hier hebben we de rol van PINT87aa bij cellulaire senescentie van hepatocellulair carcinoom (HCC) onderzocht.
Methoden: We onderzochten de functies van PINT87aa en afgeknotte PINT87aa in vitro door celproliferatie te volgen en voerden flowcytometrie uit, senescentie-geassocieerde β-galactosidase-kleuring, JC-1-kleuring die indicatief is voor mitochondriaal membraanpotentieel, de verhouding van het overlappende gebied van lichte keten Three bèta ( LC3B) en mitochondriale sondes en de verhouding van lysosomaal geassocieerd membraaneiwit 1 (LAMP1) overlapt met cytochroom c-oxidase-subeenheid 4I1 (COXIV) die mitofagie aangeeft. PINT87aa en afgeknotte PINT87aa-functies in vivo werden geverifieerd door subcutaan getransplanteerde tumoren in naakte muizen. De mogelijke binding tussen PINT87aa en forkhead subject M1 (FOXM1) werd voorspeld door middel van structurele analyse en geverifieerd door co-immunoprecipitatie en immunofluorescentie co-lokalisatie. Rescue-experimenten werden in vivo en in vitro uitgevoerd na overexpressie van FOXM1. Verder werden chromatine-immunoprecipitatie, polymerasekettingreactie en dual-luciferase-reportergentest uitgevoerd om FOXM1-binding aan de prohibitine 2 ( PHB2 ) -promotor te valideren .
Resultaten: PINT87aa was necessary verhoogd in het door waterstofperoxide geïnduceerde HCC-celsenescentiemodel. Overexpressie van PINT87aa induceerde groeiremming, cellulaire veroudering en verminderde mitofagie in vitro en in vivo . Daarentegen zou FOXM1 gain-of-function het aandeel senescente HCC-cellen gedeeltelijk kunnen verminderen en de mitofagie kunnen verbeteren. PINT87aa-overexpressie had geen invloed op de expressie van FOXM1 zelf, maar verminderde die van zijn doelwitgenen die betrokken zijn bij celcyclus en proliferatie, met establish PHB2, die betrokken was bij mitofagie en getranscribeerd door FOXM1. Structurele analyse gaf aan dat PINT87aa kon binden aan het DNA-bindende domein van FOXM1, wat werd bevestigd door co-immunoprecipitatie en immunofluorescentie co-lokalisatie. Verder hebben we aangetoond dat de afgeknotte vorm van 2 tot 39 aminozuren van het peptide effecten uitoefende die vergelijkbaar waren met de volledige vorm.
Conclusie: Onze studie stelde de rol enormous van PINT87aa als een nieuwe biomarker en een belangrijke regulator van cellulaire veroudering in HCC en identificeerde PINT87aa als een potentieel therapeutisch doelwit voor HCC.
anti- UCP5 antibody |
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| FNab09230 | FN Test | 100µg | EUR 702 |
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Description: Antibody raised against UCP5 |
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Anti-UCP5 antibody |
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| PAab09230 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-UCP5 antibody |
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| STJ190615 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Unconjugated Rabbit polyclonal to UCP5 |
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Substance P reversed sequence Peptide |
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| 20-abx266314 | Abbexa |
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0001 | Bachem | 1.0mg | EUR 544.8 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0005 | Bachem | 5.0mg | EUR 2067.6 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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UCP5 ELISA KIT|Human |
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| EF004049 | Lifescience Market | 96 Tests | EUR 826.8 |
NET Blocking Peptide (Rat) |
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| 30R-AN036 | Fitzgerald | 100 ug | EUR 289.2 |
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Description: A synthetic NET Blocking peptide for use as a blocking control in assays to test for specificity of NET antibody, catalog no. 70R-NR004 |
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Rat Calnuc Blocking Peptide |
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| 33R-2673 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NUCB1 antibody, catalog no. 70R-1118 |
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UCP3 Blocking Peptide (Rat) |
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| 30R-AU003 | Fitzgerald | 100 ug | EUR 307.2 |
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Description: A synthetic UCP3 Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 antibody, catalog no. 70R-UR005 |
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Rat C-Peptide ELISA Kit |
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| DLR-C-Peptide-Ra-48T | DL Develop | 48T | EUR 560.4 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Rat C-Peptide ELISA Kit |
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| DLR-C-Peptide-Ra-96T | DL Develop | 96T | EUR 726 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Rat C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Rat C-Peptide ELISA Kit |
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| RDR-C-Peptide-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 583.2 |
Rat C-Peptide ELISA Kit |
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| RDR-C-Peptide-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 806.4 |
Rat C-Peptide ELISA Kit |
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| RD-C-Peptide-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 558 |
Rat C-Peptide ELISA Kit |
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| RD-C-Peptide-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 771.6 |
(NANP)5 peptide (repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide |
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| NANP51-P | Alpha Diagnostics | 1 mg | EUR 416.4 |
(PPPPNAND)3 peptide (repeat-sequence peptide of the P. berghei circumsporozoite protein, CSP) control/blocking peptide |
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| PPPP321-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Custom production of antibodies in 5 Rats using customer supplied antigen (std 63 days protocol) |
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| RAT-5 | Alpha Diagnostics | 1 | EUR 1365.6 |
(NVDP)4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide |
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| NVDP41-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Influenza A virus (H5N1) matrix protein 2 hybrid sequence Control/blocking peptide |
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| M2E11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
(DRAAGQPAG)3 (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) control/blocking peptide |
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| DRAA31-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rat GTRAP41 Control/blocking peptide |
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| GTRAP41-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rat GTRAP48 Control/blocking peptide |
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| GTRAP48-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
C-Peptide Blocking Peptide |
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| 3277BP-50 | Biovision | each | EUR 183.6 |
UBE2E3 Blocking Peptide |
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| DF10000-BP | Affbiotech | 1mg | EUR 234 |
UBE2G1 Blocking Peptide |
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| DF10001-BP | Affbiotech | 1mg | EUR 234 |
UBE2U Blocking Peptide |
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| DF10002-BP | Affbiotech | 1mg | EUR 234 |
KIAA0087 Blocking Peptide |
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| DF10003-BP | Affbiotech | 1mg | EUR 234 |
ATP6V1B2 Blocking Peptide |
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| DF10004-BP | Affbiotech | 1mg | EUR 234 |
ATP6V1G3 Blocking Peptide |
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| DF10005-BP | Affbiotech | 1mg | EUR 234 |
ATP6V0A2 Blocking Peptide |
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| DF10006-BP | Affbiotech | 1mg | EUR 234 |
VCAN Blocking Peptide |
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| DF10007-BP | Affbiotech | 1mg | EUR 234 |
GOLT1A Blocking Peptide |
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| DF10008-BP | Affbiotech | 1mg | EUR 234 |
SFT2D3 Blocking Peptide |
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| DF10009-BP | Affbiotech | 1mg | EUR 234 |
SEC22B Blocking Peptide |
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| DF10010-BP | Affbiotech | 1mg | EUR 234 |
TMEM37 Blocking Peptide |
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| DF10011-BP | Affbiotech | 1mg | EUR 234 |
CACNA1D Blocking Peptide |
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| DF10012-BP | Affbiotech | 1mg | EUR 234 |
CACNA1E Blocking Peptide |
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| DF10013-BP | Affbiotech | 1mg | EUR 234 |
CACNA1G Blocking Peptide |
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| DF10014-BP | Affbiotech | 1mg | EUR 234 |
ZNHIT1 Blocking Peptide |
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| DF10015-BP | Affbiotech | 1mg | EUR 234 |
ZFHX4 Blocking Peptide |
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| DF10016-BP | Affbiotech | 1mg | EUR 234 |
ZNF295 Blocking Peptide |
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| DF10017-BP | Affbiotech | 1mg | EUR 234 |
ZNF462 Blocking Peptide |
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| DF10018-BP | Affbiotech | 1mg | EUR 234 |
ZNF600 Blocking Peptide |
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| DF10019-BP | Affbiotech | 1mg | EUR 234 |
SLC30A2 Blocking Peptide |
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| DF10020-BP | Affbiotech | 1mg | EUR 234 |
SLC39A10 Blocking Peptide |
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| DF10021-BP | Affbiotech | 1mg | EUR 234 |
ZP2 Blocking Peptide |
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| DF10022-BP | Affbiotech | 1mg | EUR 234 |
CD164L2 Blocking Peptide |
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| DF10023-BP | Affbiotech | 1mg | EUR 234 |
CC50A Blocking Peptide |
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| DF10024-BP | Affbiotech | 1mg | EUR 234 |
CCNI Blocking Peptide |
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| DF10025-BP | Affbiotech | 1mg | EUR 234 |
CD2L5 Blocking Peptide |
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| DF10026-BP | Affbiotech | 1mg | EUR 234 |
CD2L6 Blocking Peptide |
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| DF10027-BP | Affbiotech | 1mg | EUR 234 |
CD2L7 Blocking Peptide |
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| DF10028-BP | Affbiotech | 1mg | EUR 234 |
MAGA2 Blocking Peptide |
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| DF10029-BP | Affbiotech | 1mg | EUR 234 |
MAGA3 Blocking Peptide |
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| DF10030-BP | Affbiotech | 1mg | EUR 234 |
MAGA6 Blocking Peptide |
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| DF10031-BP | Affbiotech | 1mg | EUR 234 |
MAGA8 Blocking Peptide |
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| DF10032-BP | Affbiotech | 1mg | EUR 234 |
MAGAB Blocking Peptide |
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| DF10033-BP | Affbiotech | 1mg | EUR 234 |
MAGAC Blocking Peptide |
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| DF10034-BP | Affbiotech | 1mg | EUR 234 |
MAGB2 Blocking Peptide |
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| DF10035-BP | Affbiotech | 1mg | EUR 234 |
MAGB3 Blocking Peptide |
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| DF10036-BP | Affbiotech | 1mg | EUR 234 |
MAGB6 Blocking Peptide |
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| DF10037-BP | Affbiotech | 1mg | EUR 234 |
MAGBA Blocking Peptide |
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| DF10038-BP | Affbiotech | 1mg | EUR 234 |
MAGBI Blocking Peptide |
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| DF10039-BP | Affbiotech | 1mg | EUR 234 |
MAGD2 Blocking Peptide |
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| DF10040-BP | Affbiotech | 1mg | EUR 234 |
MAGE2 Blocking Peptide |
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| DF10041-BP | Affbiotech | 1mg | EUR 234 |
MAGG1 Blocking Peptide |
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| DF10042-BP | Affbiotech | 1mg | EUR 234 |
MAGH1 Blocking Peptide |
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| DF10043-BP | Affbiotech | 1mg | EUR 234 |
KITH_HHV1E Blocking Peptide |
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| DF10044-BP | Affbiotech | 1mg | EUR 234 |
CNBP Blocking Peptide |
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| DF10045-BP | Affbiotech | 1mg | EUR 234 |
HEN2 Blocking Peptide |
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| DF10046-BP | Affbiotech | 1mg | EUR 234 |
ATOH8 Blocking Peptide |
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| DF10047-BP | Affbiotech | 1mg | EUR 234 |
AKAP4 Blocking Peptide |
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| DF10048-BP | Affbiotech | 1mg | EUR 234 |
GFI1B Blocking Peptide |
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| DF10049-BP | Affbiotech | 1mg | EUR 234 |
DMRTA1 Blocking Peptide |
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| DF10050-BP | Affbiotech | 1mg | EUR 234 |
ZNF25 Blocking Peptide |
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| DF10051-BP | Affbiotech | 1mg | EUR 234 |
TSH3 Blocking Peptide |
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| DF10052-BP | Affbiotech | 1mg | EUR 234 |
LARP2 Blocking Peptide |
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| DF10053-BP | Affbiotech | 1mg | EUR 234 |
UL97 Blocking Peptide |
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| DF10054-BP | Affbiotech | 1mg | EUR 234 |
TRIM68 Blocking Peptide |
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| DF10055-BP | Affbiotech | 1mg | EUR 234 |
TCF2 Blocking Peptide |
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| DF10056-BP | Affbiotech | 1mg | EUR 234 |
ZNF839 Blocking Peptide |
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| DF10057-BP | Affbiotech | 1mg | EUR 234 |
PTRF Blocking Peptide |
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| DF10058-BP | Affbiotech | 1mg | EUR 234 |
CYFIP1 Blocking Peptide |
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| DF10059-BP | Affbiotech | 1mg | EUR 234 |
TRMT11 Blocking Peptide |
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| DF10060-BP | Affbiotech | 1mg | EUR 234 |
ZNF227 Blocking Peptide |
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| DF10061-BP | Affbiotech | 1mg | EUR 234 |
DMRTC2 Blocking Peptide |
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| DF10062-BP | Affbiotech | 1mg | EUR 234 |
YAF2 Blocking Peptide |
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| DF10063-BP | Affbiotech | 1mg | EUR 234 |
ASPM Blocking Peptide |
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| DF10064-BP | Affbiotech | 1mg | EUR 234 |
ZNF786 Blocking Peptide |
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| DF10065-BP | Affbiotech | 1mg | EUR 234 |
C16orf44 Blocking Peptide |
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| DF10066-BP | Affbiotech | 1mg | EUR 234 |
LZTR1 Blocking Peptide |
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| DF10067-BP | Affbiotech | 1mg | EUR 234 |
ZNF441 Blocking Peptide |
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| DF10068-BP | Affbiotech | 1mg | EUR 234 |
TUSC4 Blocking Peptide |
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| DF10069-BP | Affbiotech | 1mg | EUR 234 |
TP73 Blocking Peptide |
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| DF10070-BP | Affbiotech | 1mg | EUR 234 |
MINA Blocking Peptide |
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| DF10071-BP | Affbiotech | 1mg | EUR 234 |
CI098 Blocking Peptide |
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| DF10072-BP | Affbiotech | 1mg | EUR 234 |
DUX5 Blocking Peptide |
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| DF10073-BP | Affbiotech | 1mg | EUR 234 |
CIC Blocking Peptide |
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| DF10074-BP | Affbiotech | 1mg | EUR 234 |
NEB2 Blocking Peptide |
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| DF10075-BP | Affbiotech | 1mg | EUR 234 |
MYCBP Blocking Peptide |
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| DF10076-BP | Affbiotech | 1mg | EUR 234 |
ZNF577 Blocking Peptide |
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| DF10078-BP | Affbiotech | 1mg | EUR 234 |
HIPK3 Blocking Peptide |
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| DF10079-BP | Affbiotech | 1mg | EUR 234 |
POLM Blocking Peptide |
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| DF10080-BP | Affbiotech | 1mg | EUR 234 |
NOLA1 Blocking Peptide |
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| DF10081-BP | Affbiotech | 1mg | EUR 234 |
TF2L1 Blocking Peptide |
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| DF10082-BP | Affbiotech | 1mg | EUR 234 |
VPS54 Blocking Peptide |
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| DF10083-BP | Affbiotech | 1mg | EUR 234 |
RHCG Blocking Peptide |
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| DF10084-BP | Affbiotech | 1mg | EUR 234 |
RTDR1 Blocking Peptide |
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| DF10086-BP | Affbiotech | 1mg | EUR 234 |
JDP2 Blocking Peptide |
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| DF10087-BP | Affbiotech | 1mg | EUR 234 |
CDYL1 Blocking Peptide |
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| DF10088-BP | Affbiotech | 1mg | EUR 234 |
DUET Blocking Peptide |
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| DF10089-BP | Affbiotech | 1mg | EUR 234 |
CDY1 Blocking Peptide |
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| DF10090-BP | Affbiotech | 1mg | EUR 234 |
CCBE1 Blocking Peptide |
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| DF10092-BP | Affbiotech | 1mg | EUR 234 |
COX7B Blocking Peptide |
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| DF10093-BP | Affbiotech | 1mg | EUR 234 |
COX7A2L Blocking Peptide |
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| DF10094-BP | Affbiotech | 1mg | EUR 234 |
COX82 Blocking Peptide |
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| DF10095-BP | Affbiotech | 1mg | EUR 234 |
COX6A2 Blocking Peptide |
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| DF10096-BP | Affbiotech | 1mg | EUR 234 |
COX6B2 Blocking Peptide |
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| DF10097-BP | Affbiotech | 1mg | EUR 234 |
COX7A1 Blocking Peptide |
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| DF10098-BP | Affbiotech | 1mg | EUR 234 |
CYBA Blocking Peptide |
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| DF10099-BP | Affbiotech | 1mg | EUR 234 |
DEDD Blocking Peptide |
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| DF10100-BP | Affbiotech | 1mg | EUR 234 |
DNAJB2 Blocking Peptide |
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| DF10101-BP | Affbiotech | 1mg | EUR 234 |
EMID2 Blocking Peptide |
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| DF10102-BP | Affbiotech | 1mg | EUR 234 |
FBF1 Blocking Peptide |
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| DF10103-BP | Affbiotech | 1mg | EUR 234 |
GRIK5 Blocking Peptide |
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| DF10104-BP | Affbiotech | 1mg | EUR 234 |
GRIP2 Blocking Peptide |
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| DF10105-BP | Affbiotech | 1mg | EUR 234 |
IL20L2 Blocking Peptide |
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| DF10106-BP | Affbiotech | 1mg | EUR 234 |
IL22RA2 Blocking Peptide |
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| DF10107-BP | Affbiotech | 1mg | EUR 234 |
IL28RA Blocking Peptide |
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| DF10108-BP | Affbiotech | 1mg | EUR 234 |
IFNW1 Blocking Peptide |
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| DF10109-BP | Affbiotech | 1mg | EUR 234 |
IGFL2 Blocking Peptide |
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| DF10110-BP | Affbiotech | 1mg | EUR 234 |
IGFL4 Blocking Peptide |
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| DF10111-BP | Affbiotech | 1mg | EUR 234 |
IL1F7 Blocking Peptide |
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| DF10112-BP | Affbiotech | 1mg | EUR 234 |
IL1F9 Blocking Peptide |
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| DF10113-BP | Affbiotech | 1mg | EUR 234 |
IL31R Blocking Peptide |
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| DF10114-BP | Affbiotech | 1mg | EUR 234 |
IFI6 Blocking Peptide |
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| DF10115-BP | Affbiotech | 1mg | EUR 234 |
KRT84 Blocking Peptide |
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| DF10116-BP | Affbiotech | 1mg | EUR 234 |
SETMAR Blocking Peptide |
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| DF10118-BP | Affbiotech | 1mg | EUR 234 |
CCNB3 Blocking Peptide |
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| DF10120-BP | Affbiotech | 1mg | EUR 234 |
MCM8 Blocking Peptide |
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| DF10122-BP | Affbiotech | 1mg | EUR 234 |
STRN Blocking Peptide |
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| DF10123-BP | Affbiotech | 1mg | EUR 234 |
KLF17 Blocking Peptide |
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| DF10124-BP | Affbiotech | 1mg | EUR 234 |
ORC3 Blocking Peptide |
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| DF10126-BP | Affbiotech | 1mg | EUR 234 |
PIK3C2G Blocking Peptide |
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| DF10131-BP | Affbiotech | 1mg | EUR 234 |
NPR1 Blocking Peptide |
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| DF10132-BP | Affbiotech | 1mg | EUR 234 |
NPR2 Blocking Peptide |
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| DF10133-BP | Affbiotech | 1mg | EUR 234 |
CAMKK1 Blocking Peptide |
|||
| DF10134-BP | Affbiotech | 1mg | EUR 234 |
CSNK1G3 Blocking Peptide |
|||
| DF10135-BP | Affbiotech | 1mg | EUR 234 |
DYRK2 Blocking Peptide |
|||
| DF10136-BP | Affbiotech | 1mg | EUR 234 |
NEK3 Blocking Peptide |
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| DF10137-BP | Affbiotech | 1mg | EUR 234 |
PAK6 Blocking Peptide |
|||
| DF10138-BP | Affbiotech | 1mg | EUR 234 |
PCTK2 Blocking Peptide |
|||
| DF10139-BP | Affbiotech | 1mg | EUR 234 |
SNF1LK2 Blocking Peptide |
|||
| DF10140-BP | Affbiotech | 1mg | EUR 234 |
RIPK3 Blocking Peptide |
|||
| DF10141-BP | Affbiotech | 1mg | EUR 234 |
TSSK6 Blocking Peptide |
|||
| DF10142-BP | Affbiotech | 1mg | EUR 234 |
KALRN Blocking Peptide |
|||
| DF10143-BP | Affbiotech | 1mg | EUR 234 |
TSSK1 Blocking Peptide |
|||
| DF10144-BP | Affbiotech | 1mg | EUR 234 |
TXK Blocking Peptide |
|||
| DF10145-BP | Affbiotech | 1mg | EUR 234 |
NRBP1 Blocking Peptide |
|||
| DF10146-BP | Affbiotech | 1mg | EUR 234 |
APOB48R Blocking Peptide |
|||
| DF10147-BP | Affbiotech | 1mg | EUR 234 |
APOC1 Blocking Peptide |
|||
| DF10148-BP | Affbiotech | 1mg | EUR 234 |
CD1B Blocking Peptide |
|||
| DF10150-BP | Affbiotech | 1mg | EUR 234 |
CEACAM8 Blocking Peptide |
|||
| DF10151-BP | Affbiotech | 1mg | EUR 234 |
LILRB5 Blocking Peptide |
|||
| DF10152-BP | Affbiotech | 1mg | EUR 234 |
Biocide werkzaamheid van tutine en de invloed ervan op immuuncellen en expressie van groeiremmende en neurogliale peptiden in Mythimna separata (Lepidoptera: Noctuidae)
Mythimna separata Walker (Lepidoptera: Noctuidae) is een van de belangrijkste plagen die ernstige schade aan graangewassen kan veroorzaken. De ontwikkeling van botanische insecticiden met een lage toxiciteit en hoge prestaties wordt de focus van nieuw onderzoek naar pesticiden om M. separata te bestrijden. Tutin, een sesquiterpeenlactonverbinding die wordt verkregen uit Coriaria sinica Maxim, een inheemse Chinese language language giftige plant, heeft een antivoedingsmiddel, absorptie en maagvergiftiging tegen een verscheidenheid aan plagen. Om het toxische impression van tutine op de larven van M. separata te begrijpen, wilden we hun anti-voedingsmiddel, mortaliteit, verlamming, gewichtsverandering bepalen en de verspreiding van M. separata hemocyten onder verschillende concentraties van tutinebehandeling onderzoeken.
Weefselverdeling van het immuun-geassocieerde gengroei-blokkerende peptide (GBP) en neuroglian peptide (Nrg) werd gedetecteerd door reverse transcriptie polymerase kettingreactie (PCR). Verder werd real-time kwantitatieve PCR uitgevoerd om de expressieprofielen van GBP en Nrg te bepalen na verschillende concentraties van tutine-stimulatie. Onze resultaten onthulden dat tutine significante anti-feedant en insecticide activiteiten, verlamming, gewichtsverlies voor M. separata vertoonde . Bovendien had tutine een significante invloed op de morfologie van hemocyten en versterkte het de expressie van GBP en Nrg in M. separata.
Van stress afgeleide reactieve zuurstofsoorten stellen hemocyten in staat om activator van groeiblokkerend peptide (GBP) -verwerkingsenzym af te geven
Insectencytokinegroeiblokkerend peptide (GBP) wordt gesynthetiseerd als een inactieve voorloper, proGBP genaamd, die normaal in een significante concentratie aanwezig is in de hemolymfe van dieren zonder stress (Hayakawa, 1990, 1991). Onder stressomstandigheden wordt proGBP onmiddellijk omgezet tot actief GBP door een serineprotease en males denkt dat dit een belangrijke eerste stap is voor insecten om het hoofd te bieden aan door stress veroorzaakte nadelige effecten by the use of GBP-geïnduceerde fysiologische veranderingen.
Het gedetailleerde mechanisme dat ten grondslag ligt aan de proteolytische verwerking van hemolymfe proGBP bij insecten onder stressomstandigheden blijft echter onbekend. Hier hebben we aangetoond dat proGBP-verwerking door ROS geïnduceerde afgifte van een eiwitachtige concern uit hemocyten vereist die het inactieve proGBP-verwerkingsenzym activeert. De afgifte van het activatoreiwit uit hemocyten wordt geïnitieerd door een verhoging van de cytoplasmatische Ca2 + -concentratie, geïnduceerd door ROS. Daarom concludeerden we dat door stress geïnduceerde activering van proGBP ROS-afhankelijke stimulatie van een intracellulaire calciumsignaleringsroute in hemocyten vereist, gevolgd door afgifte van de hemocyt-eiwitachtige concern die specifiek het proGBP-verwerkingsenzym activeert.
Lipopolysacharide beïnvloedt het plasma en hersenen farmacokinetiek van subcutaan toegediende HsTX1 [R14a], Okay V 1,3-blokkerende peptide
Okay<sub>V</sub>1.Three is een spanningsafhankelijk kaliumkanaal dat wordt opgereguleerd bij neuro-inflammatoire aandoeningen, zoals de ziekte van Alzheimer en de ziekte van Parkinson. HsTX1[R14A] is een krachtige en selectieve peptideblokker van Okay<sub>V</sub>1.Three met het potentieel om microgliale Okay<sub>V</sub>1.Three te blokkeren, maar de opname in de hersenen zal naar verwachting beperkt zijn vanwege de beperkende aard van de bloed-hersenbarrière. Om de perifere en hersenblootstelling te beoordelen , werd een LC-MS/MS-assay ontwikkeld om HsTX1[R14A]-concentraties in muizenplasma en hersenhomogenaat te kwantificeren die betrouwbaar en reproduceerbaar waren in het bereik van 6,7-66,7 nM (r<sup>2< /sup> = 0,9765) en 15-150 pmol/g (r<sup>2</sup> = 0,9984), respectievelijk.
Om te beoordelen of neuro-inflammatie de HsTX1[R14A]-dispositie beïnvloedde, kregen C57BL/6-muizen HsTX1[R14A] subcutaan (2 mg/kg) 24 uur na een intraperitoneale dosis Escherichia coli lipopolysaccharide (LPS), die vaak wordt gebruikt om neuro-inflammatie te induceren; hersen- en plasmaconcentraties van HsTX1[R14A] werden vervolgens gedurende 120 minuten gekwantificeerd. LPS-behandelingvertraagde de daling van de HsTX1[R14A]-plasmaconcentraties aanzienlijk, vermoedelijk als gevolg van een verminderde renale klaring, en leidde tot een substantiële opname van HsTX1[R14A] in de hersenen, vermoedelijk door verstoring van de inter-endotheliale tight junctions in de hersenen. Deze studie suggereert dat HsTX1[R14A] microglia kan bereiken in voldoende concentraties om Okay<sub>V</sub>1.Three te blokkeren bij neuro-inflammatoire aandoeningen, en daarom het potentieel heeft om neurodegeneratieve ziekten te verminderen.
Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| DLR-UCP2-Ra-96T | DL Develop | 96T | EUR 861.6 |
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Uncoupling Protein 2, Mitochondrial (UCP2) in samples from tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Human Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RD-UCP2-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 625.2 |
Human Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RD-UCP2-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 867.6 |
Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RD-UCP2-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 668.4 |
Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RD-UCP2-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 930 |
Human Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RDR-UCP2-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 652.8 |
Human Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RDR-UCP2-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 907.2 |
Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RDR-UCP2-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 699.6 |
Rat Uncoupling Protein 2, Mitochondrial (UCP2) ELISA Kit |
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| RDR-UCP2-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 973.2 |
Human Uncoupling Protein 2 (UCP2) Control/blocking peptide #3 |
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| UCP23-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Substance P reversed sequence Peptide |
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| 20-abx266314 | Abbexa |
|
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0001 | Bachem | 1.0mg | EUR 544.8 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0005 | Bachem | 5.0mg | EUR 2067.6 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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GLUT4 Blocking peptide (Mouse) |
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| 30R-AG010 | Fitzgerald | 100 ug | EUR 289.2 |
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Description: A synthetic GLUT4 Blocking peptide for use as a blocking control in assays to test for specificity of GLUT4 antibody, catalog no. 70R-GR014 |
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GLUT8 Blocking Peptide (Mouse) |
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| 30R-AG011 | Fitzgerald | 100 ug | EUR 289.2 |
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Description: A synthetic GLUT8 Blocking peptide for use as a blocking control in assays to test for specificity of GLUT8 antibody, catalog no. 70R-GR008 |
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mouse Splunc2 Blocking Peptide |
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| BF0461-BP | Affbiotech | 1mg | EUR 234 |
(NANP)5 peptide (repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide |
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| NANP51-P | Alpha Diagnostics | 1 mg | EUR 416.4 |
(PPPPNAND)3 peptide (repeat-sequence peptide of the P. berghei circumsporozoite protein, CSP) control/blocking peptide |
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| PPPP321-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse C-Peptide ELISA Kit |
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| DLR-C-Peptide-Mu-48T | DL Develop | 48T | EUR 540 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse C-Peptide ELISA Kit |
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| DLR-C-Peptide-Mu-96T | DL Develop | 96T | EUR 698.4 |
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Description: A competitive inhibition quantitative ELISA assay kit for detection of Mouse C-Peptide in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
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Mouse C-Peptide ELISA Kit |
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| RDR-C-Peptide-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 558 |
Mouse C-Peptide ELISA Kit |
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| RDR-C-Peptide-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 771.6 |
Mouse C-Peptide ELISA Kit |
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| RD-C-Peptide-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 535.2 |
Mouse C-Peptide ELISA Kit |
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| RD-C-Peptide-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 738 |
Mouse UCP2 shRNA Plasmid |
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| 20-abx973302 | Abbexa |
|
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UCP2 Recombinant Protein (Mouse) |
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| RP182948 | ABM | 100 ug | Ask for price |
(NVDP)4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control/blocking peptide |
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| NVDP41-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Influenza A virus (H5N1) matrix protein 2 hybrid sequence Control/blocking peptide |
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| M2E11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
(DRAAGQPAG)3 (repeat-sequence peptide of the P. vivax circumsporozoite protein, CSP) control/blocking peptide |
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| DRAA31-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Lipin-1 Control/blocking peptide control/blocking peptide #1 |
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| LPN11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Lipin-2 Control/blocking peptide control/blocking peptide #1 |
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| LPN21-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Lipin-3 Control/blocking peptide control/blocking peptide #1 |
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| LPN31-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
UCP2 Antibody |
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| 1-CSB-PA060040 | Cusabio |
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|
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000 |
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UCP2 Antibody |
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| 1-CSB-PA299698 | Cusabio |
|
|
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:10-1:50 |
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UCP2 Antibody |
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| DF8626 | Affbiotech | 200ul | EUR 420 |
UCP2 siRNA |
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| 20-abx938928 | Abbexa |
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UCP2 siRNA |
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| 20-abx938929 | Abbexa |
|
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UCP2 Antibody |
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| 1-CSB-PA025555EA01HU | Cusabio |
|
|
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
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UCP2 Antibody |
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| 1-CSB-PA025555GA01HU | Cusabio |
|
|
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
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UCP2 Antibody |
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| 1-CSB-PA032095 | Cusabio |
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|
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Description: A polyclonal antibody against UCP2. Recognizes UCP2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100 |
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UCP2 antibody |
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| 70R-UR002 | Fitzgerald | 100 ug | EUR 768 |
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Description: Affinity purified Rabbit polyclonal UCP2 antibody |
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UCP2 antibody |
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| 70R-UR003 | Fitzgerald | 100 ug | EUR 768 |
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Description: Affinity purified Rabbit polyclonal UCP2 antibody |
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UCP2 antibody |
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| 70R-21145 | Fitzgerald | 50 ul | EUR 522 |
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Description: Rabbit polyclonal UCP2 antibody |
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UCP2 antibody |
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| 20R-UR001 | Fitzgerald | 100 ug | EUR 807.6 |
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Description: Rabbit polyclonal UCP2 antibody |
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UCP2 Antibody |
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| 40280-100ul | SAB | 100ul | EUR 302.4 |
UCP2 Antibody |
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| ABD8626 | Lifescience Market | 100 ug | EUR 525.6 |
UCP2 siRNA |
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| 20-abx905933 | Abbexa |
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anti-UCP2 |
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| YF-PA15210 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse polyclonal to UCP2 |
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anti-UCP2 |
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| YF-PA15211 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse polyclonal to UCP2 |
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anti-UCP2 |
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| YF-PA15212 | Abfrontier | 50 ug | EUR 435.6 |
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Description: Mouse polyclonal to UCP2 |
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anti-UCP2 |
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| YF-PA15213 | Abfrontier | 100 ug | EUR 483.6 |
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Description: Rabbit polyclonal to UCP2 |
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UCP2 Antibody |
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| R33648-100UG | NSJ Bioreagents | 100 ug | EUR 399 |
C-Peptide Blocking Peptide |
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| 3277BP-50 | Biovision | each | EUR 183.6 |
Mouse CYP1B1 control/blocking peptide |
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| CYP1B12-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Agouti Control/blocking peptide |
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| AGO11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Angiopoietin 1 Blocking Peptide (Mouse) |
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| 30R-AA012 | Fitzgerald | 100 ug | EUR 307.2 |
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Description: A synthetic Angiopoietin 1 Blocking peptide for use as a blocking control in assays to test for specificity of Angiopoietin 1 antibody, catalog no. 70R-AR004 |
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PPAR Delta Blocking Peptide (Mouse) |
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| 30R-AC025 | Fitzgerald | 50 ug | EUR 301.2 |
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Description: PPAR synthetic control neutralising peptide |
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CLDN6 Mouse mAb Blocking Peptide |
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| BF8001-BP | Affbiotech | 1mg | EUR 234 |
Fibronectin Mouse mAb Blocking Peptide |
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| BF9010-BP | Affbiotech | 1mg | EUR 234 |
HSP70 Mouse mAb Blocking Peptide |
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| BF9012-BP | Affbiotech | 1mg | EUR 234 |
Mouse AQP12 control/blocking peptide |
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| AQP125-P | Alpha Diagnostics | 100 ug | EUR 182.4 |
Mouse Klotho Control/blocking peptide |
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| KL11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Moesin control/blocking peptide |
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| MSN11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
UCP2 ELISA Kit (Mouse) (OKAN05918) |
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| OKAN05918 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
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Description: Description of target: ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.059 ng/mL |
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UCP2 ELISA Kit (Mouse) (OKEH05261) |
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| OKEH05261 | Aviva Systems Biology | 96 Wells | EUR 794.4 |
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Description: Description of target: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.089 ng/mL |
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Ucp2 ORF Vector (Mouse) (pORF) |
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| ORF060984 | ABM | 1.0 ug DNA | EUR 607.2 |
UCP2 ELISA Kit (Mouse) (OKCD08189) |
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| OKCD08189 | Aviva Systems Biology | 96 Wells | EUR 1201.2 |
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Description: Description of target: UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity).;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 0.059ng/mL |
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Mouse Peptide YY (PYY) control/blocking peptide # 1 |
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| PYY11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
UBE2E3 Blocking Peptide |
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| DF10000-BP | Affbiotech | 1mg | EUR 234 |
UBE2G1 Blocking Peptide |
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| DF10001-BP | Affbiotech | 1mg | EUR 234 |
UBE2U Blocking Peptide |
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| DF10002-BP | Affbiotech | 1mg | EUR 234 |
KIAA0087 Blocking Peptide |
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| DF10003-BP | Affbiotech | 1mg | EUR 234 |
ATP6V1B2 Blocking Peptide |
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| DF10004-BP | Affbiotech | 1mg | EUR 234 |
ATP6V1G3 Blocking Peptide |
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| DF10005-BP | Affbiotech | 1mg | EUR 234 |
ATP6V0A2 Blocking Peptide |
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| DF10006-BP | Affbiotech | 1mg | EUR 234 |
VCAN Blocking Peptide |
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| DF10007-BP | Affbiotech | 1mg | EUR 234 |
GOLT1A Blocking Peptide |
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| DF10008-BP | Affbiotech | 1mg | EUR 234 |
SFT2D3 Blocking Peptide |
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| DF10009-BP | Affbiotech | 1mg | EUR 234 |
SEC22B Blocking Peptide |
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| DF10010-BP | Affbiotech | 1mg | EUR 234 |
TMEM37 Blocking Peptide |
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| DF10011-BP | Affbiotech | 1mg | EUR 234 |
CACNA1D Blocking Peptide |
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| DF10012-BP | Affbiotech | 1mg | EUR 234 |
CACNA1E Blocking Peptide |
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| DF10013-BP | Affbiotech | 1mg | EUR 234 |
CACNA1G Blocking Peptide |
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| DF10014-BP | Affbiotech | 1mg | EUR 234 |
ZNHIT1 Blocking Peptide |
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| DF10015-BP | Affbiotech | 1mg | EUR 234 |
ZFHX4 Blocking Peptide |
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| DF10016-BP | Affbiotech | 1mg | EUR 234 |
ZNF295 Blocking Peptide |
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| DF10017-BP | Affbiotech | 1mg | EUR 234 |
ZNF462 Blocking Peptide |
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| DF10018-BP | Affbiotech | 1mg | EUR 234 |
ZNF600 Blocking Peptide |
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| DF10019-BP | Affbiotech | 1mg | EUR 234 |
SLC30A2 Blocking Peptide |
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| DF10020-BP | Affbiotech | 1mg | EUR 234 |
SLC39A10 Blocking Peptide |
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| DF10021-BP | Affbiotech | 1mg | EUR 234 |
ZP2 Blocking Peptide |
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| DF10022-BP | Affbiotech | 1mg | EUR 234 |
CD164L2 Blocking Peptide |
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| DF10023-BP | Affbiotech | 1mg | EUR 234 |
CC50A Blocking Peptide |
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| DF10024-BP | Affbiotech | 1mg | EUR 234 |
CCNI Blocking Peptide |
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| DF10025-BP | Affbiotech | 1mg | EUR 234 |
CD2L5 Blocking Peptide |
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| DF10026-BP | Affbiotech | 1mg | EUR 234 |
CD2L6 Blocking Peptide |
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| DF10027-BP | Affbiotech | 1mg | EUR 234 |
CD2L7 Blocking Peptide |
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| DF10028-BP | Affbiotech | 1mg | EUR 234 |
MAGA2 Blocking Peptide |
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| DF10029-BP | Affbiotech | 1mg | EUR 234 |
MAGA3 Blocking Peptide |
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| DF10030-BP | Affbiotech | 1mg | EUR 234 |
MAGA6 Blocking Peptide |
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| DF10031-BP | Affbiotech | 1mg | EUR 234 |
MAGA8 Blocking Peptide |
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| DF10032-BP | Affbiotech | 1mg | EUR 234 |
MAGAB Blocking Peptide |
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| DF10033-BP | Affbiotech | 1mg | EUR 234 |
MAGAC Blocking Peptide |
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| DF10034-BP | Affbiotech | 1mg | EUR 234 |
MAGB2 Blocking Peptide |
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| DF10035-BP | Affbiotech | 1mg | EUR 234 |
MAGB3 Blocking Peptide |
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| DF10036-BP | Affbiotech | 1mg | EUR 234 |
MAGB6 Blocking Peptide |
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| DF10037-BP | Affbiotech | 1mg | EUR 234 |
MAGBA Blocking Peptide |
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| DF10038-BP | Affbiotech | 1mg | EUR 234 |
MAGBI Blocking Peptide |
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| DF10039-BP | Affbiotech | 1mg | EUR 234 |
MAGD2 Blocking Peptide |
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| DF10040-BP | Affbiotech | 1mg | EUR 234 |
MAGE2 Blocking Peptide |
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| DF10041-BP | Affbiotech | 1mg | EUR 234 |
MAGG1 Blocking Peptide |
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| DF10042-BP | Affbiotech | 1mg | EUR 234 |
MAGH1 Blocking Peptide |
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| DF10043-BP | Affbiotech | 1mg | EUR 234 |
KITH_HHV1E Blocking Peptide |
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| DF10044-BP | Affbiotech | 1mg | EUR 234 |
CNBP Blocking Peptide |
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| DF10045-BP | Affbiotech | 1mg | EUR 234 |
HEN2 Blocking Peptide |
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| DF10046-BP | Affbiotech | 1mg | EUR 234 |
ATOH8 Blocking Peptide |
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| DF10047-BP | Affbiotech | 1mg | EUR 234 |
AKAP4 Blocking Peptide |
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| DF10048-BP | Affbiotech | 1mg | EUR 234 |
GFI1B Blocking Peptide |
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| DF10049-BP | Affbiotech | 1mg | EUR 234 |
DMRTA1 Blocking Peptide |
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| DF10050-BP | Affbiotech | 1mg | EUR 234 |
ZNF25 Blocking Peptide |
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| DF10051-BP | Affbiotech | 1mg | EUR 234 |
TSH3 Blocking Peptide |
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| DF10052-BP | Affbiotech | 1mg | EUR 234 |
LARP2 Blocking Peptide |
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| DF10053-BP | Affbiotech | 1mg | EUR 234 |
UL97 Blocking Peptide |
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| DF10054-BP | Affbiotech | 1mg | EUR 234 |
TRIM68 Blocking Peptide |
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| DF10055-BP | Affbiotech | 1mg | EUR 234 |
TCF2 Blocking Peptide |
|||
| DF10056-BP | Affbiotech | 1mg | EUR 234 |
ZNF839 Blocking Peptide |
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| DF10057-BP | Affbiotech | 1mg | EUR 234 |
PTRF Blocking Peptide |
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| DF10058-BP | Affbiotech | 1mg | EUR 234 |
CYFIP1 Blocking Peptide |
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| DF10059-BP | Affbiotech | 1mg | EUR 234 |
TRMT11 Blocking Peptide |
|||
| DF10060-BP | Affbiotech | 1mg | EUR 234 |
ZNF227 Blocking Peptide |
|||
| DF10061-BP | Affbiotech | 1mg | EUR 234 |
DMRTC2 Blocking Peptide |
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| DF10062-BP | Affbiotech | 1mg | EUR 234 |
YAF2 Blocking Peptide |
|||
| DF10063-BP | Affbiotech | 1mg | EUR 234 |
ASPM Blocking Peptide |
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| DF10064-BP | Affbiotech | 1mg | EUR 234 |
ZNF786 Blocking Peptide |
|||
| DF10065-BP | Affbiotech | 1mg | EUR 234 |
C16orf44 Blocking Peptide |
|||
| DF10066-BP | Affbiotech | 1mg | EUR 234 |
LZTR1 Blocking Peptide |
|||
| DF10067-BP | Affbiotech | 1mg | EUR 234 |
ZNF441 Blocking Peptide |
|||
| DF10068-BP | Affbiotech | 1mg | EUR 234 |
TUSC4 Blocking Peptide |
|||
| DF10069-BP | Affbiotech | 1mg | EUR 234 |
TP73 Blocking Peptide |
|||
| DF10070-BP | Affbiotech | 1mg | EUR 234 |
MINA Blocking Peptide |
|||
| DF10071-BP | Affbiotech | 1mg | EUR 234 |
CI098 Blocking Peptide |
|||
| DF10072-BP | Affbiotech | 1mg | EUR 234 |
DUX5 Blocking Peptide |
|||
| DF10073-BP | Affbiotech | 1mg | EUR 234 |
CIC Blocking Peptide |
|||
| DF10074-BP | Affbiotech | 1mg | EUR 234 |
NEB2 Blocking Peptide |
|||
| DF10075-BP | Affbiotech | 1mg | EUR 234 |
MYCBP Blocking Peptide |
|||
| DF10076-BP | Affbiotech | 1mg | EUR 234 |
ZNF577 Blocking Peptide |
|||
| DF10078-BP | Affbiotech | 1mg | EUR 234 |
HIPK3 Blocking Peptide |
|||
| DF10079-BP | Affbiotech | 1mg | EUR 234 |
POLM Blocking Peptide |
|||
| DF10080-BP | Affbiotech | 1mg | EUR 234 |
NOLA1 Blocking Peptide |
|||
| DF10081-BP | Affbiotech | 1mg | EUR 234 |
TF2L1 Blocking Peptide |
|||
| DF10082-BP | Affbiotech | 1mg | EUR 234 |
VPS54 Blocking Peptide |
|||
| DF10083-BP | Affbiotech | 1mg | EUR 234 |
RHCG Blocking Peptide |
|||
| DF10084-BP | Affbiotech | 1mg | EUR 234 |
RTDR1 Blocking Peptide |
|||
| DF10086-BP | Affbiotech | 1mg | EUR 234 |
JDP2 Blocking Peptide |
|||
| DF10087-BP | Affbiotech | 1mg | EUR 234 |
CDYL1 Blocking Peptide |
|||
| DF10088-BP | Affbiotech | 1mg | EUR 234 |
DUET Blocking Peptide |
|||
| DF10089-BP | Affbiotech | 1mg | EUR 234 |
CDY1 Blocking Peptide |
|||
| DF10090-BP | Affbiotech | 1mg | EUR 234 |
CCBE1 Blocking Peptide |
|||
| DF10092-BP | Affbiotech | 1mg | EUR 234 |
COX7B Blocking Peptide |
|||
| DF10093-BP | Affbiotech | 1mg | EUR 234 |
COX7A2L Blocking Peptide |
|||
| DF10094-BP | Affbiotech | 1mg | EUR 234 |
COX82 Blocking Peptide |
|||
| DF10095-BP | Affbiotech | 1mg | EUR 234 |
COX6A2 Blocking Peptide |
|||
| DF10096-BP | Affbiotech | 1mg | EUR 234 |
COX6B2 Blocking Peptide |
|||
| DF10097-BP | Affbiotech | 1mg | EUR 234 |
COX7A1 Blocking Peptide |
|||
| DF10098-BP | Affbiotech | 1mg | EUR 234 |
CYBA Blocking Peptide |
|||
| DF10099-BP | Affbiotech | 1mg | EUR 234 |
DEDD Blocking Peptide |
|||
| DF10100-BP | Affbiotech | 1mg | EUR 234 |
DNAJB2 Blocking Peptide |
|||
| DF10101-BP | Affbiotech | 1mg | EUR 234 |
EMID2 Blocking Peptide |
|||
| DF10102-BP | Affbiotech | 1mg | EUR 234 |
FBF1 Blocking Peptide |
|||
| DF10103-BP | Affbiotech | 1mg | EUR 234 |
GRIK5 Blocking Peptide |
|||
| DF10104-BP | Affbiotech | 1mg | EUR 234 |
GRIP2 Blocking Peptide |
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| DF10105-BP | Affbiotech | 1mg | EUR 234 |
IL20L2 Blocking Peptide |
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| DF10106-BP | Affbiotech | 1mg | EUR 234 |
IL22RA2 Blocking Peptide |
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| DF10107-BP | Affbiotech | 1mg | EUR 234 |
IL28RA Blocking Peptide |
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| DF10108-BP | Affbiotech | 1mg | EUR 234 |
IFNW1 Blocking Peptide |
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| DF10109-BP | Affbiotech | 1mg | EUR 234 |
IGFL2 Blocking Peptide |
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| DF10110-BP | Affbiotech | 1mg | EUR 234 |
IGFL4 Blocking Peptide |
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| DF10111-BP | Affbiotech | 1mg | EUR 234 |
IL1F7 Blocking Peptide |
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| DF10112-BP | Affbiotech | 1mg | EUR 234 |
IL1F9 Blocking Peptide |
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| DF10113-BP | Affbiotech | 1mg | EUR 234 |
IL31R Blocking Peptide |
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| DF10114-BP | Affbiotech | 1mg | EUR 234 |
IFI6 Blocking Peptide |
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| DF10115-BP | Affbiotech | 1mg | EUR 234 |
KRT84 Blocking Peptide |
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| DF10116-BP | Affbiotech | 1mg | EUR 234 |
SETMAR Blocking Peptide |
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| DF10118-BP | Affbiotech | 1mg | EUR 234 |
CCNB3 Blocking Peptide |
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| DF10120-BP | Affbiotech | 1mg | EUR 234 |
MCM8 Blocking Peptide |
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| DF10122-BP | Affbiotech | 1mg | EUR 234 |
STRN Blocking Peptide |
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| DF10123-BP | Affbiotech | 1mg | EUR 234 |
KLF17 Blocking Peptide |
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| DF10124-BP | Affbiotech | 1mg | EUR 234 |
ORC3 Blocking Peptide |
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| DF10126-BP | Affbiotech | 1mg | EUR 234 |
PIK3C2G Blocking Peptide |
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| DF10131-BP | Affbiotech | 1mg | EUR 234 |
NPR1 Blocking Peptide |
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| DF10132-BP | Affbiotech | 1mg | EUR 234 |
NPR2 Blocking Peptide |
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| DF10133-BP | Affbiotech | 1mg | EUR 234 |