Cellulaire veroudering bij hepatocellulair carcinoom geïnduceerd door een lang niet-coderend RNA-gecodeerd peptide PINT87aa door FOXM1-gemedieerde PHB2 te blokkeren
Rationale: Onlangs is aangetoond dat lange niet-coderende RNA’s (lncRNA’s), waarvan bekend is dat ze betrokken zijn bij de progressie van kanker bij de mens, coderen voor peptiden met biologische functies, maar de rol van door lncRNA gecodeerde peptiden bij cellulaire veroudering is grotendeels onontgonnen. We rapporteerden eerder de tumor-onderdrukkende rol van PINT87aa, een peptide dat wordt gecodeerd door het lange intergene niet-eiwit coderende RNA, p53-geïnduceerde transcript ( LINC-PINT). Hier hebben we de rol van PINT87aa bij cellulaire senescentie van hepatocellulair carcinoom (HCC) onderzocht.
Methoden: We onderzochten de functies van PINT87aa en afgeknotte PINT87aa in vitro door celproliferatie te volgen en voerden flowcytometrie uit, senescentie-geassocieerde β-galactosidase-kleuring, JC-1-kleuring die indicatief is voor mitochondriaal membraanpotentieel, de verhouding van het overlappende gebied van lichte keten Three bèta ( LC3B) en mitochondriale sondes en de verhouding van lysosomaal geassocieerd membraaneiwit 1 (LAMP1) overlapt met cytochroom c-oxidase-subeenheid 4I1 (COXIV) die mitofagie aangeeft. PINT87aa en afgeknotte PINT87aa-functies in vivo werden geverifieerd door subcutaan getransplanteerde tumoren in naakte muizen. De mogelijke binding tussen PINT87aa en forkhead subject M1 (FOXM1) werd voorspeld door middel van structurele analyse en geverifieerd door co-immunoprecipitatie en immunofluorescentie co-lokalisatie. Rescue-experimenten werden in vivo en in vitro uitgevoerd na overexpressie van FOXM1. Verder werden chromatine-immunoprecipitatie, polymerasekettingreactie en dual-luciferase-reportergentest uitgevoerd om FOXM1-binding aan de prohibitine 2 ( PHB2 ) -promotor te valideren .
Resultaten: PINT87aa was necessary verhoogd in het door waterstofperoxide geïnduceerde HCC-celsenescentiemodel. Overexpressie van PINT87aa induceerde groeiremming, cellulaire veroudering en verminderde mitofagie in vitro en in vivo . Daarentegen zou FOXM1 gain-of-function het aandeel senescente HCC-cellen gedeeltelijk kunnen verminderen en de mitofagie kunnen verbeteren. PINT87aa-overexpressie had geen invloed op de expressie van FOXM1 zelf, maar verminderde die van zijn doelwitgenen die betrokken zijn bij celcyclus en proliferatie, met establish PHB2, die betrokken was bij mitofagie en getranscribeerd door FOXM1. Structurele analyse gaf aan dat PINT87aa kon binden aan het DNA-bindende domein van FOXM1, wat werd bevestigd door co-immunoprecipitatie en immunofluorescentie co-lokalisatie. Verder hebben we aangetoond dat de afgeknotte vorm van 2 tot 39 aminozuren van het peptide effecten uitoefende die vergelijkbaar waren met de volledige vorm.
Conclusie: Onze studie stelde de rol enormous van PINT87aa als een nieuwe biomarker en een belangrijke regulator van cellulaire veroudering in HCC en identificeerde PINT87aa als een potentieel therapeutisch doelwit voor HCC.
UCP2 Blocking Peptide |
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| DF8626-BP | Affbiotech | 1mg | EUR 234 |
UCP3 Blocking Peptide |
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| DF6443-BP | Affbiotech | 1mg | EUR 234 |
UCP3 Blocking Peptide |
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| 20-abx161750 | Abbexa |
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0001 | Bachem | 1.0mg | EUR 544.8 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0005 | Bachem | 5.0mg | EUR 2067.6 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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Substance P reversed sequence Peptide |
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| 20-abx266314 | Abbexa |
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UCP2 Blocking Peptide (Mouse) |
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| 30R-AU001 | Fitzgerald | 100 ug | EUR 289.2 |
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Description: A synthetic UCP2 Blocking peptide for use as a blocking control in assays to test for specificity of UCP2 antibody, catalog no. 20R-UR001 |
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UCP3 C-terminal Blocking Peptide |
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| 30R-AU002 | Fitzgerald | 100 ug | EUR 289.2 |
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Description: A synthetic UCP3 C-terminal Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 C-terminal antibody, catalog no. 70R-UR004 |
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Rat Uncoupling Protein 3 (UCP3) Control/blocking peptide #3 |
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| UCP33-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rat Uncoupling Protein 4 (UCP4) Control/blocking peptide #2 |
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| UCP42-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Borrelia Vmp-like sequence expressed (VlsE) C6 peptide (>90%) for ELISA |
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| VLSE65-UL | Alpha Diagnostics | 100 ug | EUR 416.4 |
NET Blocking Peptide (Rat) |
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| 30R-AN036 | Fitzgerald | 100 ug | EUR 289.2 |
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Description: A synthetic NET Blocking peptide for use as a blocking control in assays to test for specificity of NET antibody, catalog no. 70R-NR004 |
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Mouse Uncoupling Protein 1 (UCP1) Control/blocking peptide # 1 |
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| UCP11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Uncoupling Protein 1 (UCP1) Control/blocking peptide # 2 |
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| UCP12-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Uncoupling Protein 2 (UCP2) Control/blocking peptide #1 |
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| UCP21-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Uncoupling Protein 2 (UCP2) Control/blocking peptide #2 |
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| UCP22-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 2 (UCP2) Control/blocking peptide #3 |
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| UCP23-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #1 |
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| UCP31-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #2 |
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| UCP32-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #4 |
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| UCP34-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 4 (UCP4) Control/blocking peptide #1 |
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| UCP41-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Borrelia Vmp-like sequence expressed (VlsE) C6 peptide-Biotin (>90%) for ELISA |
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| VLSE65-BTN | Alpha Diagnostics | 100 ug | EUR 489.6 |
Rat Calnuc Blocking Peptide |
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| 33R-2673 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NUCB1 antibody, catalog no. 70R-1118 |
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Rabbit Anti-Borrelia Vmp-like sequence expressed (VlsE) C6 peptide IgG, aff pure |
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| VLSE61-A | Alpha Diagnostics | 100 ul | EUR 578.4 |
Rat GTRAP41 Control/blocking peptide |
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| GTRAP41-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rat GTRAP48 Control/blocking peptide |
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| GTRAP48-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
40787 Blocking Peptide |
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| 33R-2900 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT1 antibody, catalog no. 70R-9926 |
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hCG_1982709 Blocking Peptide |
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| 33R-3437 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1982709 antibody, catalog no. 70R-9054 |
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hCG_2042202 Blocking Peptide |
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| 33R-3770 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2042202 antibody, catalog no. 70R-9063 |
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hCG_1660138 Blocking Peptide |
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| 33R-4078 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1660138 antibody, catalog no. 70R-9044 |
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hCG_1646157 Blocking Peptide |
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| 33R-4162 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9034 |
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hCG_20426 Blocking Peptide |
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| 33R-4753 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8776 |
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hCG_2007354 Blocking Peptide |
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| 33R-5366 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2007354 antibody, catalog no. 70R-9061 |
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hCG_20426 Blocking Peptide |
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| 33R-5875 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8775 |
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HCG_1745121 Blocking Peptide |
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| 33R-6558 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1745121 antibody, catalog no. 70R-3903 |
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hCG_1646157 Blocking Peptide |
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| 33R-7420 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9035 |
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TK Blocking Peptide |
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| AF7678-BP | Affbiotech | 1mg | EUR 234 |
Rb Blocking Peptide |
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| AF7698-BP | Affbiotech | 1mg | EUR 234 |
T Blocking Peptide |
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| BF0015-BP | Affbiotech | 1mg | EUR 234 |
A1 Blocking Peptide |
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| 3401BP-50 | Biovision | each | EUR 183.6 |
Ub Blocking Peptide |
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| 20-abx063395 | Abbexa |
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E7 Blocking Peptide |
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| BF0311-BP | Affbiotech | 1mg | EUR 234 |
AR Blocking Peptide |
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| BF0418-BP | Affbiotech | 1mg | EUR 234 |
PR Blocking Peptide |
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| BF0581-BP | Affbiotech | 1mg | EUR 234 |
RB Blocking Peptide |
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| BF0614-BP | Affbiotech | 1mg | EUR 234 |
ER Blocking Peptide |
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| BF0674-BP | Affbiotech | 1mg | EUR 234 |
GK Blocking Peptide |
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| AF0829-BP | Affbiotech | 1mg | EUR 234 |
GR Blocking Peptide |
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| AF5004-BP | Affbiotech | 1mg | EUR 234 |
GR Blocking Peptide |
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| AF6066-BP | Affbiotech | 1mg | EUR 234 |
GR Blocking Peptide |
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| AF6067-BP | Affbiotech | 1mg | EUR 234 |
TK Blocking Peptide |
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| AF6068-BP | Affbiotech | 1mg | EUR 234 |
IR Blocking Peptide |
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| AF6098-BP | Affbiotech | 1mg | EUR 234 |
IR Blocking Peptide |
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| AF6099-BP | Affbiotech | 1mg | EUR 234 |
F7 Blocking Peptide |
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| 33R-1026 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DLG4 antibody, catalog no. 70R-4080 |
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GC Blocking Peptide |
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| 33R-10350 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10252 |
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A1 Blocking Peptide |
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| 33R-10744 | Fitzgerald | 50 ug | EUR 229.2 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of A1 antibody, catalog no. 70R-11802 |
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KC Blocking Peptide |
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| 33R-11041 | Fitzgerald | 50 ug | EUR 229.2 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KC antibody, catalog no. 70R-12298 |
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F2 Blocking Peptide |
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| 33R-1783 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F2 antibody, catalog no. 70R-8514 |
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PB Blocking Peptide |
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| 33R-2067 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of pb antibody, catalog no. 70R-2192 |
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AC Blocking Peptide |
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| 33R-3003 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ac antibody, catalog no. 70R-1978 |
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XK Blocking Peptide |
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| 33R-7655 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7274 |
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F7 Blocking Peptide |
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| 33R-7835 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F7 antibody, catalog no. 70R-9970 |
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PC Blocking Peptide |
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| 33R-8614 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PC antibody, catalog no. 70R-9828 |
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TH Blocking Peptide |
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| 33R-3167 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-7854 |
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F8 Blocking Peptide |
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| 33R-3569 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F8 antibody, catalog no. 70R-9971 |
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NP Blocking Peptide |
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| 33R-3631 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NP antibody, catalog no. 70R-2286 |
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GC Blocking Peptide |
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| 33R-4418 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10253 |
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XK Blocking Peptide |
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| 33R-5017 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7169 |
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SI Blocking Peptide |
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| 33R-5258 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7230 |
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GK Blocking Peptide |
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| 33R-5595 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GK antibody, catalog no. 70R-4533 |
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TH Blocking Peptide |
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| 33R-6309 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-10442 |
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HB Blocking Peptide |
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| 33R-6336 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hb antibody, catalog no. 70R-3198 |
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N Blocking Peptide |
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| 33R-6561 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LSM8 antibody, catalog no. 70R-4590 |
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SI Blocking Peptide |
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| 33R-6891 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7205 |
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KC Blocking Peptide |
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| 5212BP-50 | Biovision | each | EUR 183.6 |
OR Blocking Peptide |
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| DF10250-BP | Affbiotech | 1mg | EUR 234 |
CP Blocking Peptide |
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| DF9369-BP | Affbiotech | 1mg | EUR 234 |
C7 Blocking Peptide |
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| DF9410-BP | Affbiotech | 1mg | EUR 234 |
MB Blocking Peptide |
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| DF7358-BP | Affbiotech | 1mg | EUR 234 |
FH Blocking Peptide |
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| DF7460-BP | Affbiotech | 1mg | EUR 234 |
AR Blocking Peptide |
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| DF6783-BP | Affbiotech | 1mg | EUR 234 |
C5 Blocking Peptide |
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| DF7719-BP | Affbiotech | 1mg | EUR 234 |
GC Blocking Peptide |
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| DF7840-BP | Affbiotech | 1mg | EUR 234 |
TG Blocking Peptide |
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| DF7885-BP | Affbiotech | 1mg | EUR 234 |
F5 Blocking Peptide |
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| DF8265-BP | Affbiotech | 1mg | EUR 234 |
Ob Blocking Peptide |
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| DF8583-BP | Affbiotech | 1mg | EUR 234 |
ST Blocking Peptide |
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| DF8616-BP | Affbiotech | 1mg | EUR 234 |
C6 Blocking Peptide |
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| DF3963-BP | Affbiotech | 1mg | EUR 234 |
C9 Blocking Peptide |
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| DF3964-BP | Affbiotech | 1mg | EUR 234 |
MB Blocking Peptide |
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| DF4194-BP | Affbiotech | 1mg | EUR 234 |
NT Blocking Peptide |
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| DF4245-BP | Affbiotech | 1mg | EUR 234 |
PC Blocking Peptide |
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| DF4364-BP | Affbiotech | 1mg | EUR 234 |
F3 Blocking Peptide |
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| DF6400-BP | Affbiotech | 1mg | EUR 234 |
HP Blocking Peptide |
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| DF6467-BP | Affbiotech | 1mg | EUR 234 |
F9 Blocking Peptide |
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| DF6474-BP | Affbiotech | 1mg | EUR 234 |
GK Blocking Peptide |
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| DF3151-BP | Affbiotech | 1mg | EUR 234 |
FX Blocking Peptide |
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| 20-abx161511 | Abbexa |
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GW Blocking Peptide |
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| 20-abx162574 | Abbexa |
|
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Rat UT2 Control/blocking peptide #1 |
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| RUT21-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
PEPT1 Blocking Peptide |
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| 20-abx063272 | Abbexa |
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SKI Blocking Peptide |
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| AF7536-BP | Affbiotech | 1mg | EUR 234 |
EED Blocking Peptide |
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| AF7558-BP | Affbiotech | 1mg | EUR 234 |
TXN Blocking Peptide |
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| AF7577-BP | Affbiotech | 1mg | EUR 234 |
Bim Blocking Peptide |
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| AF7620-BP | Affbiotech | 1mg | EUR 234 |
Bim Blocking Peptide |
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| AF7621-BP | Affbiotech | 1mg | EUR 234 |
LAT Blocking Peptide |
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| AF7625-BP | Affbiotech | 1mg | EUR 234 |
LAT Blocking Peptide |
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| AF7626-BP | Affbiotech | 1mg | EUR 234 |
DR6 Blocking Peptide |
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| AF7652-BP | Affbiotech | 1mg | EUR 234 |
PZR Blocking Peptide |
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| AF7665-BP | Affbiotech | 1mg | EUR 234 |
PZR Blocking Peptide |
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| AF7666-BP | Affbiotech | 1mg | EUR 234 |
PZR Blocking Peptide |
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| AF7667-BP | Affbiotech | 1mg | EUR 234 |
Myc Blocking Peptide |
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| AF7674-BP | Affbiotech | 1mg | EUR 234 |
p53 Blocking Peptide |
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| AF7685-BP | Affbiotech | 1mg | EUR 234 |
p53 Blocking Peptide |
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| AF7686-BP | Affbiotech | 1mg | EUR 234 |
APP Blocking Peptide |
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| AF7687-BP | Affbiotech | 1mg | EUR 234 |
Lck Blocking Peptide |
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| AF7694-BP | Affbiotech | 1mg | EUR 234 |
Lck Blocking Peptide |
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| AF7695-BP | Affbiotech | 1mg | EUR 234 |
LCK Blocking Peptide |
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| AF7696-BP | Affbiotech | 1mg | EUR 234 |
Fyn Blocking Peptide |
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| AF7697-BP | Affbiotech | 1mg | EUR 234 |
NPM Blocking Peptide |
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| AF7703-BP | Affbiotech | 1mg | EUR 234 |
Lyn Blocking Peptide |
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| AF7708-BP | Affbiotech | 1mg | EUR 234 |
HCK Blocking Peptide |
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| AF7711-BP | Affbiotech | 1mg | EUR 234 |
Bcr Blocking Peptide |
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| AF7715-BP | Affbiotech | 1mg | EUR 234 |
Bcr Blocking Peptide |
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| AF7716-BP | Affbiotech | 1mg | EUR 234 |
HS1 Blocking Peptide |
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| AF7726-BP | Affbiotech | 1mg | EUR 234 |
FER Blocking Peptide |
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| AF7737-BP | Affbiotech | 1mg | EUR 234 |
UBF Blocking Peptide |
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| AF7743-BP | Affbiotech | 1mg | EUR 234 |
MAK Blocking Peptide |
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| AF7757-BP | Affbiotech | 1mg | EUR 234 |
CBL Blocking Peptide |
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| AF7763-BP | Affbiotech | 1mg | EUR 234 |
AXL Blocking Peptide |
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| AF7793-BP | Affbiotech | 1mg | EUR 234 |
YB1 Blocking Peptide |
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| AF7832-BP | Affbiotech | 1mg | EUR 234 |
YB1 Blocking Peptide |
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| AF7833-BP | Affbiotech | 1mg | EUR 234 |
BTK Blocking Peptide |
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| AF7854-BP | Affbiotech | 1mg | EUR 234 |
BTK Blocking Peptide |
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| AF7855-BP | Affbiotech | 1mg | EUR 234 |
SF1 Blocking Peptide |
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| AF7895-BP | Affbiotech | 1mg | EUR 234 |
Bad Blocking Peptide |
|||
| AF7927-BP | Affbiotech | 1mg | EUR 234 |
AT2 Blocking Peptide |
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| 30R-AA024 | Fitzgerald | 100 ug | EUR 289.2 |
|
Description: A synthetic AT2 Blocking peptide for use as a blocking control in assays to test for specificity of AT2 antibody, catalog no. 70R-AR006 |
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PKA Blocking Peptide |
|||
| 3115BP-50 | Biovision | each | EUR 183.6 |
Bax Blocking Peptide |
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| 3032BP-50 | Biovision | each | EUR 183.6 |
p53 Blocking Peptide |
|||
| 3036RBP-50 | Biovision | each | EUR 183.6 |
PBR Blocking Peptide |
|||
| 3044BP-50 | Biovision | each | EUR 183.6 |
DR4 Blocking Peptide |
|||
| 3061BP-50 | Biovision | each | EUR 183.6 |
DR5 Blocking Peptide |
|||
| 3062BP-50 | Biovision | each | EUR 183.6 |
PPY Blocking Peptide |
|||
| BF0012-BP | Affbiotech | 1mg | EUR 234 |
ILK Blocking Peptide |
|||
| BF0030-BP | Affbiotech | 1mg | EUR 234 |
CD5 Blocking Peptide |
|||
| BF0031-BP | Affbiotech | 1mg | EUR 234 |
SRY Blocking Peptide |
|||
| BF0037-BP | Affbiotech | 1mg | EUR 234 |
SST Blocking Peptide |
|||
| BF0042-BP | Affbiotech | 1mg | EUR 234 |
CD6 Blocking Peptide |
|||
| BF0044-BP | Affbiotech | 1mg | EUR 234 |
EGF Blocking Peptide |
|||
| BF0066-BP | Affbiotech | 1mg | EUR 234 |
KDR Blocking Peptide |
|||
| BF0068-BP | Affbiotech | 1mg | EUR 234 |
AGT Blocking Peptide |
|||
| BF0069-BP | Affbiotech | 1mg | EUR 234 |
SYK Blocking Peptide |
|||
| BF0074-BP | Affbiotech | 1mg | EUR 234 |
FER Blocking Peptide |
|||
| BF0076-BP | Affbiotech | 1mg | EUR 234 |
LAL Blocking Peptide |
|||
| BF0079-BP | Affbiotech | 1mg | EUR 234 |
DCX Blocking Peptide |
|||
| BF0083-BP | Affbiotech | 1mg | EUR 234 |
CRK Blocking Peptide |
|||
| BF0088-BP | Affbiotech | 1mg | EUR 234 |
CEA Blocking Peptide |
|||
| BF0092-BP | Affbiotech | 1mg | EUR 234 |
TEC Blocking Peptide |
|||
| BF0100-BP | Affbiotech | 1mg | EUR 234 |
AAT Blocking Peptide |
|||
| BF0101-BP | Affbiotech | 1mg | EUR 234 |
FOS Blocking Peptide |
|||
| BF0115-BP | Affbiotech | 1mg | EUR 234 |
CRP Blocking Peptide |
|||
| BF0116-BP | Affbiotech | 1mg | EUR 234 |
BLK Blocking Peptide |
|||
| BF0124-BP | Affbiotech | 1mg | EUR 234 |
HK1 Blocking Peptide |
|||
| BF0126-BP | Affbiotech | 1mg | EUR 234 |
PGR Blocking Peptide |
|||
| BF0135-BP | Affbiotech | 1mg | EUR 234 |
FRK Blocking Peptide |
|||
| BF0136-BP | Affbiotech | 1mg | EUR 234 |
Biocide werkzaamheid van tutine en de invloed ervan op immuuncellen en expressie van groeiremmende en neurogliale peptiden in Mythimna separata (Lepidoptera: Noctuidae)
Mythimna separata Walker (Lepidoptera: Noctuidae) is een van de belangrijkste plagen die ernstige schade aan graangewassen kan veroorzaken. De ontwikkeling van botanische insecticiden met een lage toxiciteit en hoge prestaties wordt de focus van nieuw onderzoek naar pesticiden om M. separata te bestrijden. Tutin, een sesquiterpeenlactonverbinding die wordt verkregen uit Coriaria sinica Maxim, een inheemse Chinese language language giftige plant, heeft een antivoedingsmiddel, absorptie en maagvergiftiging tegen een verscheidenheid aan plagen. Om het toxische impression van tutine op de larven van M. separata te begrijpen, wilden we hun anti-voedingsmiddel, mortaliteit, verlamming, gewichtsverandering bepalen en de verspreiding van M. separata hemocyten onder verschillende concentraties van tutinebehandeling onderzoeken.
Weefselverdeling van het immuun-geassocieerde gengroei-blokkerende peptide (GBP) en neuroglian peptide (Nrg) werd gedetecteerd door reverse transcriptie polymerase kettingreactie (PCR). Verder werd real-time kwantitatieve PCR uitgevoerd om de expressieprofielen van GBP en Nrg te bepalen na verschillende concentraties van tutine-stimulatie. Onze resultaten onthulden dat tutine significante anti-feedant en insecticide activiteiten, verlamming, gewichtsverlies voor M. separata vertoonde . Bovendien had tutine een significante invloed op de morfologie van hemocyten en versterkte het de expressie van GBP en Nrg in M. separata.
Van stress afgeleide reactieve zuurstofsoorten stellen hemocyten in staat om activator van groeiblokkerend peptide (GBP) -verwerkingsenzym af te geven
Insectencytokinegroeiblokkerend peptide (GBP) wordt gesynthetiseerd als een inactieve voorloper, proGBP genaamd, die normaal in een significante concentratie aanwezig is in de hemolymfe van dieren zonder stress (Hayakawa, 1990, 1991). Onder stressomstandigheden wordt proGBP onmiddellijk omgezet tot actief GBP door een serineprotease en males denkt dat dit een belangrijke eerste stap is voor insecten om het hoofd te bieden aan door stress veroorzaakte nadelige effecten by the use of GBP-geïnduceerde fysiologische veranderingen.
Het gedetailleerde mechanisme dat ten grondslag ligt aan de proteolytische verwerking van hemolymfe proGBP bij insecten onder stressomstandigheden blijft echter onbekend. Hier hebben we aangetoond dat proGBP-verwerking door ROS geïnduceerde afgifte van een eiwitachtige concern uit hemocyten vereist die het inactieve proGBP-verwerkingsenzym activeert. De afgifte van het activatoreiwit uit hemocyten wordt geïnitieerd door een verhoging van de cytoplasmatische Ca2 + -concentratie, geïnduceerd door ROS. Daarom concludeerden we dat door stress geïnduceerde activering van proGBP ROS-afhankelijke stimulatie van een intracellulaire calciumsignaleringsroute in hemocyten vereist, gevolgd door afgifte van de hemocyt-eiwitachtige concern die specifiek het proGBP-verwerkingsenzym activeert.
Lipopolysacharide beïnvloedt het plasma en hersenen farmacokinetiek van subcutaan toegediende HsTX1 [R14a], Okay V 1,3-blokkerende peptide
Okay<sub>V</sub>1.Three is een spanningsafhankelijk kaliumkanaal dat wordt opgereguleerd bij neuro-inflammatoire aandoeningen, zoals de ziekte van Alzheimer en de ziekte van Parkinson. HsTX1[R14A] is een krachtige en selectieve peptideblokker van Okay<sub>V</sub>1.Three met het potentieel om microgliale Okay<sub>V</sub>1.Three te blokkeren, maar de opname in de hersenen zal naar verwachting beperkt zijn vanwege de beperkende aard van de bloed-hersenbarrière. Om de perifere en hersenblootstelling te beoordelen , werd een LC-MS/MS-assay ontwikkeld om HsTX1[R14A]-concentraties in muizenplasma en hersenhomogenaat te kwantificeren die betrouwbaar en reproduceerbaar waren in het bereik van 6,7-66,7 nM (r<sup>2< /sup> = 0,9765) en 15-150 pmol/g (r<sup>2</sup> = 0,9984), respectievelijk.
Om te beoordelen of neuro-inflammatie de HsTX1[R14A]-dispositie beïnvloedde, kregen C57BL/6-muizen HsTX1[R14A] subcutaan (2 mg/kg) 24 uur na een intraperitoneale dosis Escherichia coli lipopolysaccharide (LPS), die vaak wordt gebruikt om neuro-inflammatie te induceren; hersen- en plasmaconcentraties van HsTX1[R14A] werden vervolgens gedurende 120 minuten gekwantificeerd. LPS-behandelingvertraagde de daling van de HsTX1[R14A]-plasmaconcentraties aanzienlijk, vermoedelijk als gevolg van een verminderde renale klaring, en leidde tot een substantiële opname van HsTX1[R14A] in de hersenen, vermoedelijk door verstoring van de inter-endotheliale tight junctions in de hersenen. Deze studie suggereert dat HsTX1[R14A] microglia kan bereiken in voldoende concentraties om Okay<sub>V</sub>1.Three te blokkeren bij neuro-inflammatoire aandoeningen, en daarom het potentieel heeft om neurodegeneratieve ziekten te verminderen.
UCP3 Blocking Peptide |
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| 30R-AU006 | Fitzgerald | 100 ug | EUR 289.2 |
|
Description: A synthetic UCP3 Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 antibody, catalog no. 20R-UR003 |
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UCP1 Blocking Peptide |
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| DF7720-BP | Affbiotech | 1mg | EUR 234 |
UCP3 Blocking Peptide |
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| DF6443-BP | Affbiotech | 1mg | EUR 234 |
UCP3 Blocking Peptide |
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| 20-abx161750 | Abbexa |
|
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Human Uncoupling Protein 2 (UCP2) Control/blocking peptide #3 |
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| UCP23-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0001 | Bachem | 1.0mg | EUR 544.8 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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Erythropoietin Mimetic Peptide Sequence 20 |
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| H-4344.0005 | Bachem | 5.0mg | EUR 2067.6 |
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Description: Sum Formula: C72H99N17O17S2; CAS# [203397-62-0] net |
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UCP3 Blocking Peptide (Rat) |
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| 30R-AU003 | Fitzgerald | 100 ug | EUR 307.2 |
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Description: A synthetic UCP3 Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 antibody, catalog no. 70R-UR005 |
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UCP5 Blocking Peptide (Rat) |
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| 30R-AU004 | Fitzgerald | 100 ug | EUR 262.8 |
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Description: A synthetic UCP5 peptide for use as a blocking control in assays to test for specificity of UCP5 antibody, catalog no. 20R-UR002 |
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Substance P reversed sequence Peptide |
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| 20-abx266314 | Abbexa |
|
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Mouse Uncoupling Protein 1 (UCP1) Control/blocking peptide # 1 |
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| UCP11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Uncoupling Protein 1 (UCP1) Control/blocking peptide # 2 |
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| UCP12-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
UCP3 C-terminal Blocking Peptide |
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| 30R-AU002 | Fitzgerald | 100 ug | EUR 289.2 |
|
Description: A synthetic UCP3 C-terminal Blocking peptide for use as a blocking control in assays to test for specificity of UCP3 C-terminal antibody, catalog no. 70R-UR004 |
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Mouse Lipin-1 Control/blocking peptide control/blocking peptide #1 |
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| LPN11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Lipin-2 Control/blocking peptide control/blocking peptide #1 |
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| LPN21-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Lipin-3 Control/blocking peptide control/blocking peptide #1 |
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| LPN31-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
GLUT4 Blocking peptide (Mouse) |
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| 30R-AG010 | Fitzgerald | 100 ug | EUR 289.2 |
|
Description: A synthetic GLUT4 Blocking peptide for use as a blocking control in assays to test for specificity of GLUT4 antibody, catalog no. 70R-GR014 |
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GLUT8 Blocking Peptide (Mouse) |
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| 30R-AG011 | Fitzgerald | 100 ug | EUR 289.2 |
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Description: A synthetic GLUT8 Blocking peptide for use as a blocking control in assays to test for specificity of GLUT8 antibody, catalog no. 70R-GR008 |
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mouse Splunc2 Blocking Peptide |
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| BF0461-BP | Affbiotech | 1mg | EUR 234 |
Borrelia Vmp-like sequence expressed (VlsE) C6 peptide (>90%) for ELISA |
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| VLSE65-UL | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Peptide YY (PYY) control/blocking peptide # 1 |
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| PYY11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
CLDN6 Mouse mAb Blocking Peptide |
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| BF8001-BP | Affbiotech | 1mg | EUR 234 |
HSP70 Mouse mAb Blocking Peptide |
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| BF9012-BP | Affbiotech | 1mg | EUR 234 |
PPAR Delta Blocking Peptide (Mouse) |
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| 30R-AC025 | Fitzgerald | 50 ug | EUR 301.2 |
|
Description: PPAR synthetic control neutralising peptide |
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Rat Uncoupling Protein 3 (UCP3) Control/blocking peptide #3 |
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| UCP33-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rat Uncoupling Protein 4 (UCP4) Control/blocking peptide #2 |
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| UCP42-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rat Uncoupling Protein 5 (UCP5) Control/blocking peptide #1 |
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| UCP51-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse AQP12 control/blocking peptide |
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| AQP125-P | Alpha Diagnostics | 100 ug | EUR 182.4 |
Mouse Agouti Control/blocking peptide |
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| AGO11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse CYP1B1 control/blocking peptide |
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| CYP1B12-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Moesin control/blocking peptide |
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| MSN11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Klotho Control/blocking peptide |
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| KL11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #1 |
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| UCP31-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #2 |
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| UCP32-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 3 (UCP3) Control/blocking peptide #4 |
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| UCP34-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 4 (UCP4) Control/blocking peptide #1 |
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| UCP41-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Human Uncoupling Protein 5 (UCP5) Control/blocking peptide #2 |
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| UCP52-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Angiopoietin 1 Blocking Peptide (Mouse) |
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| 30R-AA012 | Fitzgerald | 100 ug | EUR 307.2 |
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Description: A synthetic Angiopoietin 1 Blocking peptide for use as a blocking control in assays to test for specificity of Angiopoietin 1 antibody, catalog no. 70R-AR004 |
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Fibronectin Mouse mAb Blocking Peptide |
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| BF9010-BP | Affbiotech | 1mg | EUR 234 |
Borrelia Vmp-like sequence expressed (VlsE) C6 peptide-Biotin (>90%) for ELISA |
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| VLSE65-BTN | Alpha Diagnostics | 100 ug | EUR 489.6 |
HIF1 alpha Mouse mAb Blocking Peptide |
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| BF8002-BP | Affbiotech | 1mg | EUR 234 |
Control/Blocking peptide Mouse BCL-2 |
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| BCL21-C | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Aven Control/blocking peptide # 2 |
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| AVEN12-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Per1 Control/blocking peptide #1 |
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| PER11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Per2 Control/blocking peptide #1 |
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| PER21-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Per3 Control/blocking peptide #1 |
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| PER31-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Collagen III Mouse mAb Blocking Peptide |
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| BF9208-BP | Affbiotech | 1mg | EUR 234 |
Mouse Clock Control/blocking peptide # 1 |
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| CLO11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Leptin Control/blocking peptide # 1 |
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| OB11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Leptin Control/blocking peptide # 2 |
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| OB12-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Rabbit Anti-Borrelia Vmp-like sequence expressed (VlsE) C6 peptide IgG, aff pure |
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| VLSE61-A | Alpha Diagnostics | 100 ul | EUR 578.4 |
ErbB-2/HER2 Mouse mAb Blocking Peptide |
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| BF9201-BP | Affbiotech | 1mg | EUR 234 |
Mouse/Human AQP11 control/blocking peptide |
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| AQP115-P | Alpha Diagnostics | 100 ug | EUR 182.4 |
alpha-tubulin Mouse mAb Blocking Peptide |
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| BF9210-BP | Affbiotech | 1mg | EUR 234 |
Mouse Meckelin (Mks3) Control/blocking peptide |
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| AB-23268-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse Hephaestin (Hp) control/blocking peptide |
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| HEPH11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Vasoactive intestinal peptide (VIP) Control/blocking peptide #1 |
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| VIP16-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Neprilysin (NEP) Control/blocking peptide |
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| NEP11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Merlin 2 Control/blocking peptide #1 |
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| MERL21-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse PiT1 (GLVR1) Control/blocking peptide #1 |
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| PIT11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Orexin-B Control/blocking peptide # 1 |
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| OXB11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse dermatopontin (Dpt) Control/blocking peptide |
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| AB-23026-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse p/CIP/p300 Control/blocking peptide # 1 |
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| CIP11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse p/CIP/p300 Control/blocking peptide # 2 |
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| CIP12-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Annexin A3 (Anxa3) Control/Blocking peptide |
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| ANX311-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Neuromedin U control/blocking peptide # 4 |
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| NMU71-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
Control/Blocking peptide for Mouse Vimentin (Vim) |
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| VIM11-C | Alpha Diagnostics | 100 ug | EUR 196.8 |
Mouse Tubby Protein Control/blocking peptide # 1 |
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| TUBBY11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
40787 Blocking Peptide |
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| 33R-2900 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SEPT1 antibody, catalog no. 70R-9926 |
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hCG_1982709 Blocking Peptide |
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| 33R-3437 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1982709 antibody, catalog no. 70R-9054 |
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hCG_2042202 Blocking Peptide |
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| 33R-3770 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2042202 antibody, catalog no. 70R-9063 |
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hCG_1660138 Blocking Peptide |
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| 33R-4078 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1660138 antibody, catalog no. 70R-9044 |
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hCG_1646157 Blocking Peptide |
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| 33R-4162 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9034 |
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hCG_20426 Blocking Peptide |
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| 33R-4753 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8776 |
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hCG_2007354 Blocking Peptide |
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| 33R-5366 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_2007354 antibody, catalog no. 70R-9061 |
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hCG_20426 Blocking Peptide |
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| 33R-5875 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_20426 antibody, catalog no. 70R-8775 |
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HCG_1745121 Blocking Peptide |
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| 33R-6558 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1745121 antibody, catalog no. 70R-3903 |
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hCG_1646157 Blocking Peptide |
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| 33R-7420 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hCG_1646157 antibody, catalog no. 70R-9035 |
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TK Blocking Peptide |
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| AF7678-BP | Affbiotech | 1mg | EUR 234 |
Rb Blocking Peptide |
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| AF7698-BP | Affbiotech | 1mg | EUR 234 |
T Blocking Peptide |
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| BF0015-BP | Affbiotech | 1mg | EUR 234 |
A1 Blocking Peptide |
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| 3401BP-50 | Biovision | each | EUR 183.6 |
Ub Blocking Peptide |
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| 20-abx063395 | Abbexa |
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E7 Blocking Peptide |
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| BF0311-BP | Affbiotech | 1mg | EUR 234 |
AR Blocking Peptide |
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| BF0418-BP | Affbiotech | 1mg | EUR 234 |
PR Blocking Peptide |
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| BF0581-BP | Affbiotech | 1mg | EUR 234 |
RB Blocking Peptide |
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| BF0614-BP | Affbiotech | 1mg | EUR 234 |
ER Blocking Peptide |
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| BF0674-BP | Affbiotech | 1mg | EUR 234 |
GK Blocking Peptide |
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| AF0829-BP | Affbiotech | 1mg | EUR 234 |
GR Blocking Peptide |
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| AF5004-BP | Affbiotech | 1mg | EUR 234 |
GR Blocking Peptide |
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| AF6066-BP | Affbiotech | 1mg | EUR 234 |
GR Blocking Peptide |
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| AF6067-BP | Affbiotech | 1mg | EUR 234 |
TK Blocking Peptide |
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| AF6068-BP | Affbiotech | 1mg | EUR 234 |
IR Blocking Peptide |
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| AF6098-BP | Affbiotech | 1mg | EUR 234 |
IR Blocking Peptide |
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| AF6099-BP | Affbiotech | 1mg | EUR 234 |
F7 Blocking Peptide |
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| 33R-1026 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DLG4 antibody, catalog no. 70R-4080 |
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GC Blocking Peptide |
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| 33R-10350 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10252 |
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A1 Blocking Peptide |
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| 33R-10744 | Fitzgerald | 50 ug | EUR 229.2 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of A1 antibody, catalog no. 70R-11802 |
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KC Blocking Peptide |
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| 33R-11041 | Fitzgerald | 50 ug | EUR 229.2 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of KC antibody, catalog no. 70R-12298 |
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F2 Blocking Peptide |
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| 33R-1783 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F2 antibody, catalog no. 70R-8514 |
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PB Blocking Peptide |
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| 33R-2067 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of pb antibody, catalog no. 70R-2192 |
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AC Blocking Peptide |
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| 33R-3003 | Fitzgerald | 100 ug | EUR 216 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of ac antibody, catalog no. 70R-1978 |
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XK Blocking Peptide |
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| 33R-7655 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7274 |
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F7 Blocking Peptide |
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| 33R-7835 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F7 antibody, catalog no. 70R-9970 |
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PC Blocking Peptide |
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| 33R-8614 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of PC antibody, catalog no. 70R-9828 |
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TH Blocking Peptide |
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| 33R-3167 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-7854 |
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F8 Blocking Peptide |
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| 33R-3569 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of F8 antibody, catalog no. 70R-9971 |
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NP Blocking Peptide |
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| 33R-3631 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NP antibody, catalog no. 70R-2286 |
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GC Blocking Peptide |
|||
| 33R-4418 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GC antibody, catalog no. 70R-10253 |
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XK Blocking Peptide |
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| 33R-5017 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of XK antibody, catalog no. 70R-7169 |
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SI Blocking Peptide |
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| 33R-5258 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7230 |
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GK Blocking Peptide |
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| 33R-5595 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of GK antibody, catalog no. 70R-4533 |
|||
TH Blocking Peptide |
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| 33R-6309 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TH antibody, catalog no. 70R-10442 |
|||
HB Blocking Peptide |
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| 33R-6336 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of hb antibody, catalog no. 70R-3198 |
|||
N Blocking Peptide |
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| 33R-6561 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of LSM8 antibody, catalog no. 70R-4590 |
|||
SI Blocking Peptide |
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| 33R-6891 | Fitzgerald | 100 ug | EUR 216 |
|
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of SI antibody, catalog no. 70R-7205 |
|||
KC Blocking Peptide |
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| 5212BP-50 | Biovision | each | EUR 183.6 |
OR Blocking Peptide |
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| DF10250-BP | Affbiotech | 1mg | EUR 234 |
CP Blocking Peptide |
|||
| DF9369-BP | Affbiotech | 1mg | EUR 234 |
C7 Blocking Peptide |
|||
| DF9410-BP | Affbiotech | 1mg | EUR 234 |
MB Blocking Peptide |
|||
| DF7358-BP | Affbiotech | 1mg | EUR 234 |
FH Blocking Peptide |
|||
| DF7460-BP | Affbiotech | 1mg | EUR 234 |
AR Blocking Peptide |
|||
| DF6783-BP | Affbiotech | 1mg | EUR 234 |
C5 Blocking Peptide |
|||
| DF7719-BP | Affbiotech | 1mg | EUR 234 |
GC Blocking Peptide |
|||
| DF7840-BP | Affbiotech | 1mg | EUR 234 |
TG Blocking Peptide |
|||
| DF7885-BP | Affbiotech | 1mg | EUR 234 |
F5 Blocking Peptide |
|||
| DF8265-BP | Affbiotech | 1mg | EUR 234 |
Ob Blocking Peptide |
|||
| DF8583-BP | Affbiotech | 1mg | EUR 234 |
ST Blocking Peptide |
|||
| DF8616-BP | Affbiotech | 1mg | EUR 234 |
C6 Blocking Peptide |
|||
| DF3963-BP | Affbiotech | 1mg | EUR 234 |
C9 Blocking Peptide |
|||
| DF3964-BP | Affbiotech | 1mg | EUR 234 |
MB Blocking Peptide |
|||
| DF4194-BP | Affbiotech | 1mg | EUR 234 |
NT Blocking Peptide |
|||
| DF4245-BP | Affbiotech | 1mg | EUR 234 |
PC Blocking Peptide |
|||
| DF4364-BP | Affbiotech | 1mg | EUR 234 |
F3 Blocking Peptide |
|||
| DF6400-BP | Affbiotech | 1mg | EUR 234 |
HP Blocking Peptide |
|||
| DF6467-BP | Affbiotech | 1mg | EUR 234 |
F9 Blocking Peptide |
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| DF6474-BP | Affbiotech | 1mg | EUR 234 |
GK Blocking Peptide |
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| DF3151-BP | Affbiotech | 1mg | EUR 234 |
FX Blocking Peptide |
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| 20-abx161511 | Abbexa |
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GW Blocking Peptide |
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| 20-abx162574 | Abbexa |
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Mouse pannexin 3 (Panx3) Control/blocking peptide |
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| AB-23242-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse pannexin 3 (Panx3) Control/blocking peptide |
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| AB-23243-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse pannexin 3 (Panx3) Control/blocking peptide |
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| AB-23244-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse pannexin 1 (Panx1) Control/blocking peptide |
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| AB-23246-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse pannexin 1 (Panx1) Control/blocking peptide |
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| AB-23247-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse pannexin 2 (Panx2) Control/blocking peptide |
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| AB-23260-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse aquaporin 2 (AQP2) Control/blocking peptide |
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| AB-23265-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse pannexin 1 (Panx1) Control/blocking peptide |
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| AB-23016-P | Alpha Diagnostics | 100ug | EUR 196.8 |
Mouse/Human Mahogany Control/blocking peptide #1 |
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| MAHG11-P | Alpha Diagnostics | 100 ug | EUR 196.8 |
PEPT1 Blocking Peptide |
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| 20-abx063272 | Abbexa |
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SKI Blocking Peptide |
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| AF7536-BP | Affbiotech | 1mg | EUR 234 |
EED Blocking Peptide |
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| AF7558-BP | Affbiotech | 1mg | EUR 234 |
TXN Blocking Peptide |
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| AF7577-BP | Affbiotech | 1mg | EUR 234 |
Bim Blocking Peptide |
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| AF7620-BP | Affbiotech | 1mg | EUR 234 |
Bim Blocking Peptide |
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| AF7621-BP | Affbiotech | 1mg | EUR 234 |
LAT Blocking Peptide |
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| AF7625-BP | Affbiotech | 1mg | EUR 234 |
LAT Blocking Peptide |
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| AF7626-BP | Affbiotech | 1mg | EUR 234 |
DR6 Blocking Peptide |
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| AF7652-BP | Affbiotech | 1mg | EUR 234 |
PZR Blocking Peptide |
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| AF7665-BP | Affbiotech | 1mg | EUR 234 |
PZR Blocking Peptide |
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| AF7666-BP | Affbiotech | 1mg | EUR 234 |
PZR Blocking Peptide |
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| AF7667-BP | Affbiotech | 1mg | EUR 234 |
Myc Blocking Peptide |
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| AF7674-BP | Affbiotech | 1mg | EUR 234 |
p53 Blocking Peptide |
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| AF7685-BP | Affbiotech | 1mg | EUR 234 |
p53 Blocking Peptide |
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| AF7686-BP | Affbiotech | 1mg | EUR 234 |
APP Blocking Peptide |
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| AF7687-BP | Affbiotech | 1mg | EUR 234 |
Lck Blocking Peptide |
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| AF7694-BP | Affbiotech | 1mg | EUR 234 |
Lck Blocking Peptide |
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| AF7695-BP | Affbiotech | 1mg | EUR 234 |
LCK Blocking Peptide |
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| AF7696-BP | Affbiotech | 1mg | EUR 234 |
Fyn Blocking Peptide |
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| AF7697-BP | Affbiotech | 1mg | EUR 234 |
NPM Blocking Peptide |
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| AF7703-BP | Affbiotech | 1mg | EUR 234 |
Lyn Blocking Peptide |
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| AF7708-BP | Affbiotech | 1mg | EUR 234 |
HCK Blocking Peptide |
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| AF7711-BP | Affbiotech | 1mg | EUR 234 |
Bcr Blocking Peptide |
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| AF7715-BP | Affbiotech | 1mg | EUR 234 |
Bcr Blocking Peptide |
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| AF7716-BP | Affbiotech | 1mg | EUR 234 |
HS1 Blocking Peptide |
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| AF7726-BP | Affbiotech | 1mg | EUR 234 |
FER Blocking Peptide |
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| AF7737-BP | Affbiotech | 1mg | EUR 234 |
UBF Blocking Peptide |
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| AF7743-BP | Affbiotech | 1mg | EUR 234 |
MAK Blocking Peptide |
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| AF7757-BP | Affbiotech | 1mg | EUR 234 |
CBL Blocking Peptide |
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| AF7763-BP | Affbiotech | 1mg | EUR 234 |
AXL Blocking Peptide |
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| AF7793-BP | Affbiotech | 1mg | EUR 234 |
YB1 Blocking Peptide |
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| AF7832-BP | Affbiotech | 1mg | EUR 234 |
YB1 Blocking Peptide |
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| AF7833-BP | Affbiotech | 1mg | EUR 234 |
BTK Blocking Peptide |
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| AF7854-BP | Affbiotech | 1mg | EUR 234 |
BTK Blocking Peptide |
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| AF7855-BP | Affbiotech | 1mg | EUR 234 |
SF1 Blocking Peptide |
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| AF7895-BP | Affbiotech | 1mg | EUR 234 |
Bad Blocking Peptide |
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| AF7927-BP | Affbiotech | 1mg | EUR 234 |
AT2 Blocking Peptide |
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| 30R-AA024 | Fitzgerald | 100 ug | EUR 289.2 |
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Description: A synthetic AT2 Blocking peptide for use as a blocking control in assays to test for specificity of AT2 antibody, catalog no. 70R-AR006 |
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PKA Blocking Peptide |
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| 3115BP-50 | Biovision | each | EUR 183.6 |
Bax Blocking Peptide |
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| 3032BP-50 | Biovision | each | EUR 183.6 |
p53 Blocking Peptide |
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| 3036RBP-50 | Biovision | each | EUR 183.6 |
PBR Blocking Peptide |
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| 3044BP-50 | Biovision | each | EUR 183.6 |