Een nieuw bioengineered fragmentpeptide van Vasostatin-1 oefent farmacologische activiteiten van gladde spieren en anti-angiogene effecten uit through het blokkeren van de VEGFR-signaleringsroute
Chromogranine A (CgA) is een hydrofiel glycoproteïne dat wordt afgegeven door postganglionaire sympathische neuronen. CgA bestaat uit een enkele peptideketen die talrijke gepaarde basische residuen bevat, die typische splitsingsplaatsen in prohormonen zijn om bioactieve peptiden te genereren. Het wordt erkend als een diagnostische en prognostische serummarker voor neuro-endocriene tumoren. Vasostatine-1 is een van de meest geconserveerde regio’s van CgA en heeft numerous remmende biologische activiteiten. In deze studie werd een nieuw peptidefragment gesynthetiseerd dat drie typische functionele structuren van Vasostatin-1 bevat. Dit unieke bioengineered Vasostatin-1 Derived Peptide (genaamd V1DP) omvat een sterk geconserveerd domein tussen gewervelde soorten in het N-terminale gebied, bestaande uit een disulfidebrug gevormd door twee cysteïneresiduen op respectievelijk aminozuurposities 17 en 38. Trouwens, V1DP bevat twee significante tripeptide-herkenningssequenties: de aminozuurtriplets, RGD en KGD. Onze gegevens toonden aan dat V1DP een dosisafhankelijke relaxatie van de arteriële gladde spier van de rat kon induceren en ook de contractie-activiteit van de gladde spier van de baarmoeder van de rat kon verhogen. Wat nog belangrijker is, we ontdekten dat V1DP de proliferatie van kankercellen remt, de HUVEC-celmigratie moduleert en een anti-angiogenese-effect vertoont, zowel in vitro en in vivo.
We hebben het feitelijke mechanisme van V1DP verder onderzocht en onze resultaten bevestigden dat V1DP de vasculaire endotheliale groeifactorreceptor (VEGFR) -signalering remt. We koppelden V1DP aan de apo-structuren van VEGFR2 en onderzochten de stabiliteit van het peptide in de eiwitpockets. Onze simulatie- en vrije-energieberekeningen gaven aan dat V1DP kan binden aan het katalytische domein en regulatoire domeinzakken, afhankelijk van of de conformationele toestand van het eiwit JM-in of JM-out is. Al met al suggereerden onze gegevens dat V1DP een rol speelt als regulator van de endotheelcelfunctie en farmacologische homeostase van gladde spieren. V1DP is een in water oplosbaar en biologisch stabiel peptide en zou zich verder kunnen ontwikkelen als een anti-angiogeen geneesmiddel voor de behandeling van kanker.
BCL-XL (Phospho-Ser62) Polyclonal Conjugated Antibody |
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| C11066 | SAB | 100ul | EUR 476.4 |
Phospho-BCL-XL (Thr47) Blocking Peptide |
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| AF3414-BP | Affbiotech | 1mg | EUR 234 |
BCL-XL Blocking Peptide |
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| AF6414-BP | Affbiotech | 1mg | EUR 234 |
BCL-XL Blocking Peptide |
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| AF6415-BP | Affbiotech | 1mg | EUR 234 |
Bcl xL Blocking Peptide |
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| 33R-10466 | Fitzgerald | 50 ug | EUR 418.8 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bcl xL antibody, catalog no. 20R-1516 |
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Bcl-xL Blocking Peptide |
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| 33R-10707 | Fitzgerald | 50 ug | EUR 229.2 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bcl-xL antibody, catalog no. 70R-11750 |
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Bcl-xL Blocking Peptide |
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| 3312BP-50 | Biovision | EUR 183.6 | |
Polyclonal BCL2L1 / BCL-XL Antibody (Ser62) |
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| APG02242G | Leading Biology | 0.05mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BCL2L1 / BCL-XL (Ser62). This antibody is tested and proven to work in the following applications: |
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BCL-XL (Phospho-Ser62) Colorimetric Cell-Based ELISA Kit |
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| EKC2364 | BosterBio | 100ul | EUR 686.4 |
Bcl-xL Peptide |
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| 3341P | ProSci | 0.05 mg | EUR 197.7 |
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Description: (CT) Bcl-xL peptide |
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Phospho-Myc (Ser62) Blocking Peptide |
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| AF3054-BP | Affbiotech | 1mg | EUR 234 |
Phospho-BCL-XL (Ser62) Colorimetric Cell-Based ELISA Kit (OKAG01898) |
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| OKAG01898 | Aviva Systems Biology | 2 x 96 Wells | EUR 888 |
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Description: Description of target: ;Species reactivity: Human: S62, Mouse: S62, Rat: S62;Application: ELISA;Assay info: Assay Type: Cell-Based Subtype: Phospho Detection Method: Colorimetric 450 nm;Sensitivity: |
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Phospho-ATF2 (Ser62/44) Blocking Peptide |
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| AF3176-BP | Affbiotech | 1mg | EUR 234 |
Phospho-BCL-XL (Thr47) Antibody |
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| AF3414 | Affbiotech | 200ul | EUR 420 |
Phospho- BCL- XL (Thr47) Antibody |
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| ABF3414 | Lifescience Market | 100 ug | EUR 525.6 |
Bcl-x (phospho Ser62) Polyclonal Antibody |
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| ES7034-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against Bcl-x (phospho Ser62) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Bcl-x (phospho Ser62) Polyclonal Antibody |
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| ES7034-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against Bcl-x (phospho Ser62) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Bcl-x (phospho Ser62) Polyclonal Antibody |
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| ABP56035-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of Bcl-x phospho Ser62) from Human, Mouse, Rat. This Bcl-x phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Bcl-x around the phosphorylation site of S62 |
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Bcl-x (phospho Ser62) Polyclonal Antibody |
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| ABP56035-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of Bcl-x phospho Ser62) from Human, Mouse, Rat. This Bcl-x phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Bcl-x around the phosphorylation site of S62 |
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Bcl-x (phospho Ser62) Polyclonal Antibody |
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| ABP56035-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of Bcl-x phospho Ser62) from Human, Mouse, Rat. This Bcl-x phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Bcl-x around the phosphorylation site of S62 |
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Phospho-ENSA (Ser67) /ARPP19 (Ser62) Blocking Peptide |
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| AF4381-BP | Affbiotech | 1mg | EUR 234 |
BCL-XL Antibody |
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| DF6015 | Affbiotech | 200ul | EUR 420 |
BCL-XL Antibody |
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| AF6414 | Affbiotech | 200ul | EUR 420 |
BCL-XL Antibody |
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| AF6415 | Affbiotech | 200ul | EUR 420 |
BCL-XL antibody |
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| 70R-34417 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal BCL-XL antibody |
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Bcl-xL antibody |
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| 70R-21426 | Fitzgerald | 50 ul | EUR 522 |
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Description: Rabbit polyclonal Bcl-xL antibody |
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Bcl-XL Antibody |
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| 48688-100ul | SAB | 100ul | EUR 399.6 |
Bcl-XL Antibody |
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| 48688-50ul | SAB | 50ul | EUR 286.8 |
Bcl-xL antibody |
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| 70R-11750 | Fitzgerald | 100 ug | EUR 564 |
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Description: Rabbit polyclonal Bcl-xL antibody |
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Bcl-xL Antibody |
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| 24247-100ul | SAB | 100ul | EUR 468 |
Bcl xL antibody |
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| 20R-1516 | Fitzgerald | 100 ug | EUR 781.2 |
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Description: Rabbit polyclonal Bcl xL antibody |
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BCL XL antibody |
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| 20R-2242 | Fitzgerald | 50 ug | EUR 337.2 |
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Description: Rabbit polyclonal BCL XL antibody |
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Bcl-xL Antibody |
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| 3312-100 | Biovision | EUR 430.8 | |
Bcl-xL Antibody |
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| 3312-30T | Biovision | EUR 175.2 | |
Bcl-xL Antibody |
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| 3341-002mg | ProSci | 0.02 mg | EUR 206.18 |
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Description: Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents. |
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Bcl-xL Antibody |
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| 3341-01mg | ProSci | 0.1 mg | EUR 523.7 |
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Description: Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents. |
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BCL- XL Antibody |
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| ABF6414 | Lifescience Market | 100 ug | EUR 525.6 |
BCL- XL Antibody |
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| ABF6415 | Lifescience Market | 100 ug | EUR 525.6 |
Phospho-BCL-10 (Ser138) Blocking Peptide |
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| AF8215-BP | Affbiotech | 1mg | EUR 234 |
Phospho-Bcl-6 (Ser343) Blocking Peptide |
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| AF8244-BP | Affbiotech | 1mg | EUR 234 |
Phospho-BCL-2 (Thr74) Blocking Peptide |
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| AF8465-BP | Affbiotech | 1mg | EUR 234 |
Phospho-BCL-3 (Ser402) Blocking Peptide |
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| AF8466-BP | Affbiotech | 1mg | EUR 234 |
Phospho-BCL-2 (Ser87) Blocking Peptide |
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| AF3138-BP | Affbiotech | 1mg | EUR 234 |
Phospho-BCL-2 (Thr69) Blocking Peptide |
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| AF3139-BP | Affbiotech | 1mg | EUR 234 |
Phospho-BCL-2 (Ser70) Blocking Peptide |
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| AF3140-BP | Affbiotech | 1mg | EUR 234 |
Phospho-Bcl-2 (Thr56) Blocking Peptide |
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| AF4400-BP | Affbiotech | 1mg | EUR 234 |
Phospho-BCL-3 (Ser41) Blocking Peptide |
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| AF7256-BP | Affbiotech | 1mg | EUR 234 |
Bcl-Xl Polyclonal Antibody |
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| ABP57290-003ml | Abbkine | 0.03ml | EUR 189.6 |
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Description: A polyclonal antibody for detection of Bcl-Xl from Human, Mouse, Rat. This Bcl-Xl antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein |
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Bcl-Xl Polyclonal Antibody |
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| ABP57290-01ml | Abbkine | 0.1ml | EUR 346.8 |
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Description: A polyclonal antibody for detection of Bcl-Xl from Human, Mouse, Rat. This Bcl-Xl antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein |
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Bcl-Xl Polyclonal Antibody |
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| ABP57290-02ml | Abbkine | 0.2ml | EUR 496.8 |
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Description: A polyclonal antibody for detection of Bcl-Xl from Human, Mouse, Rat. This Bcl-Xl antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein |
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Bcl-XL Conjugated Antibody |
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| C48688 | SAB | 100ul | EUR 476.4 |
Bcl-Xl Polyclonal Antibody |
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| ES8287-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/Mouse/Rat. This antibody is tested and validated for IHC |
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Bcl-Xl Polyclonal Antibody |
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| ES8287-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/Mouse/Rat. This antibody is tested and validated for IHC |
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BCL-XL antibody (Thr115) |
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| 70R-34416 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal BCL-XL antibody (Thr115) |
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Mouse Bcl-XL Antibody |
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| 35630-05111 | AssayPro | 150 ug | EUR 313.2 |
BCL-XL (pS62) Antibody |
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| 20-abx119182 | Abbexa |
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BCL-XL (pT115) Antibody |
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| 20-abx119349 | Abbexa |
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BCL-XL (pS62) Antibody |
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| abx011693-100ug | Abbexa | 100 ug | EUR 526.8 |
BCL-XL (pT47) Antibody |
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| abx011695-100ug | Abbexa | 100 ug | EUR 526.8 |
Polyclonal Bcl-xL Antibody |
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| APG02228G | Leading Biology | 0.1 mg | EUR 790.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Bcl-xL . This antibody is tested and proven to work in the following applications: |
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Polyclonal Bcl-xL Antibody |
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| APG02229G | Leading Biology | 0.1mg | EUR 580.8 |
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Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Bcl-xL . This antibody is tested and proven to work in the following applications: |
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Bcl-Xl Polyclonal Antibody |
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| EA258-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/ Rat/ Mouse. This antibody is tested and validated for IHC |
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Bcl-Xl Polyclonal Antibody |
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| EA258-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/ Rat/ Mouse. This antibody is tested and validated for IHC |
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Anti-Bcl-Xl antibody |
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| STJ97501 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Rabbit polyclonal to Bcl-Xl. |
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Bcl-xl protein |
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| E20-80114 | EnoGene | 20ug | EUR 489.6 |
Bcl-xl protein |
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| E20-80115 | EnoGene | 20ug | EUR 489.6 |
Apoptosis Regulator Bcl-X (BCL-XL) Antibody |
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| 20-abx011694 | Abbexa |
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Apoptosis Regulator Bcl-X (BCL-XL) Antibody |
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| abx011696-100ug | Abbexa | 100 ug | EUR 526.8 |
Apoptosis Regulator Bcl-X (BCL-XL) Antibody |
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| abx412040-01mg | Abbexa | 0.1 mg | EUR 610.8 |
BCL-XL (Ab-62) Antibody |
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| 21061-100ul | SAB | 100ul | EUR 302.4 |
BCL-XL (Ab-62) Antibody |
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| 21061-50ul | SAB | 50ul | EUR 224.4 |
Bcl-XL recombinant monoclonal antibody |
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| A5091 | Bimake | 100ul X 3 | EUR 714 |
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Description: A recombinant monoclonal antibody from rabbit against human Bcl-XL for WB, IHC,ELISA |
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Anti-Bcl-XL/BCL2L1 Antibody |
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| A00181 | BosterBio | 100ug/vial | EUR 400.8 |
Bcl-xL Recombinant Protein |
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| 91-087 | ProSci | 0.05 mg | EUR 651.3 |
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Description: Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis. |
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Bcl-XL Rabbit mAb |
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| A19703-100ul | Abclonal | 100 ul | EUR 492 |
Bcl-XL Rabbit mAb |
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| A19703-200ul | Abclonal | 200 ul | EUR 685.2 |
Bcl-XL Rabbit mAb |
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| A19703-20ul | Abclonal | 20 ul | EUR 265.2 |
Bcl-XL Rabbit mAb |
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| A19703-50ul | Abclonal | 50 ul | EUR 344.4 |
pCDH- puro- Bcl- XL |
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| PVT10290 | Lifescience Market | 2 ug | EUR 361.2 |
Phospho-MYC (Ser62) Antibody |
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| CSB-PA062361- | Cusabio | EUR 402 | |
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Description: A polyclonal antibody against Phospho-MYC (Ser62). Recognizes Phospho-MYC (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200 |
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Phospho-MYC (Ser62) Antibody |
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| CSB-PA062361-100ul | Cusabio | 100ul | EUR 434.4 |
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Description: A polyclonal antibody against Phospho-MYC (Ser62). Recognizes Phospho-MYC (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200 |
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Phospho-BCL2L1 (Ser62) Antibody |
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| CSB-PA786016- | Cusabio | EUR 402 | |
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Description: A polyclonal antibody against Phospho-BCL2L1 (Ser62). Recognizes Phospho-BCL2L1 (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; |
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Phospho-BCL2L1 (Ser62) Antibody |
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| CSB-PA786016-100ul | Cusabio | 100ul | EUR 434.4 |
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Description: A polyclonal antibody against Phospho-BCL2L1 (Ser62). Recognizes Phospho-BCL2L1 (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF; |
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Myc (Phospho-Ser62) Antibody |
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| 11311-100ul | SAB | 100ul | EUR 302.4 |
Myc (Phospho-Ser62) Antibody |
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| 11311-50ul | SAB | 50ul | EUR 224.4 |
STMN1 (Phospho-Ser62) Antibody |
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| 20-abx012587 | Abbexa |
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Phospho- Myc (Ser62) Antibody |
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| ABF3054 | Lifescience Market | 100 ug | EUR 525.6 |
BCL-3 Blocking Peptide |
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| DF10317-BP | Affbiotech | 1mg | EUR 234 |
BCL-3 Blocking Peptide |
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| AF7756-BP | Affbiotech | 1mg | EUR 234 |
Bcl-2 Blocking Peptide |
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| AF4700-BP | Affbiotech | 1mg | EUR 234 |
BCL-2 Blocking Peptide |
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| AF6139-BP | Affbiotech | 1mg | EUR 234 |
BCL-2 Blocking Peptide |
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| AF0769-BP | Affbiotech | 1mg | EUR 234 |
Bcl-B Blocking Peptide |
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| 3695BP-50 | Biovision | EUR 183.6 | |
Bcl 6 Blocking Peptide |
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| 33R-10485 | Fitzgerald | 50 ug | EUR 418.8 |
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Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bcl 6 antibody, catalog no. 20R-1556 |
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Bcl-Rambo Blocking Peptide |
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| 3671BP-50 | Biovision | EUR 183.6 | |
Bcl-3 Blocking Peptide |
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| 3407BP-50 | Biovision | EUR 183.6 | |
Bcl-6 Blocking Peptide |
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| 3408BP-50 | Biovision | EUR 183.6 | |
Bcl-2 Blocking Peptide |
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| 3033BP-50 | Biovision | EUR 183.6 | |
Bcl-2 Blocking Peptide |
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| BF9103-BP | Affbiotech | 1mg | EUR 234 |
Mouse Bcl-XL Antibody (Biotin Conjugate) |
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| 35630-05121 | AssayPro | 150 ug | EUR 442.8 |
Anti-Bcl-XL Rabbit Monoclonal Antibody |
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| M00181-1 | BosterBio | 100ug/vial | EUR 476.4 |
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Description: Rabbit Monoclonal Bcl-XL Antibody. Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D | Stressmarq | 0.1ml | EUR 424.8 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is unconjugated. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-A390 | Stressmarq | 0.1ml | EUR 481.2 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 390. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-A488 | Stressmarq | 0.1ml | EUR 480 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 488. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-A565 | Stressmarq | 0.1ml | EUR 480 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 565. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-A594 | Stressmarq | 0.1ml | EUR 480 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 594. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-A633 | Stressmarq | 0.1ml | EUR 480 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 633. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-A655 | Stressmarq | 0.1ml | EUR 480 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 655. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-A680 | Stressmarq | 0.1ml | EUR 480 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 680. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-A700 | Stressmarq | 0.1ml | EUR 480 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 700. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-ALP | Stressmarq | 0.1ml | EUR 472.8 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Alkaline Phosphatase. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-APC | Stressmarq | 0.1ml | EUR 478.8 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to APC . |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-APCCY7 | Stressmarq | 0.1ml | EUR 565.2 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to APC/Cy7. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-BI | Stressmarq | 0.1ml | EUR 475.2 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Biotin. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-DY350 | Stressmarq | 0.1ml | EUR 496.8 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 350. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-DY405 | Stressmarq | 0.1ml | EUR 483.6 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 405. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-DY488 | Stressmarq | 0.1ml | EUR 471.6 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 488. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-DY594 | Stressmarq | 0.1ml | EUR 474 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 594. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-DY633 | Stressmarq | 0.1ml | EUR 468 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 633. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-FITC | Stressmarq | 0.1ml | EUR 470.4 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to FITC. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-HRP | Stressmarq | 0.1ml | EUR 465.6 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to HRP. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-P594 | Stressmarq | 0.1ml | EUR 488.4 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to PE/ATTO 594. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-PCP | Stressmarq | 0.1ml | EUR 478.8 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to PerCP. |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-RPE | Stressmarq | 0.1ml | EUR 476.4 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to RPE . |
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Antibody for Human Bcl-xL (pSer62) |
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| SPC-1352D-STR | Stressmarq | 0.1ml | EUR 477.6 |
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Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Streptavidin. |
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BCL-XL (Phospho-Thr47) Colorimetric Cell-Based ELISA Kit |
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| EKC2190 | BosterBio | 100ul | EUR 686.4 |
BCL-XL Cell ELISA Kit |
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| abx595060-96tests | Abbexa | 96 tests | EUR 764.4 |
anti-BCL-XL (Ab-62) |
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| LF-PA20050 | Abfrontier | 100 ul | EUR 400.8 |
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Description: Rabbit polyclonal to BCL-XL |
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Phospho-ATF2 (Ser62/Ser44) Antibody |
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| AF3176 | Affbiotech | 200ul | EUR 420 |
Phospho-ENSA (Ser67/Ser62) Antibody |
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| AF4381 | Affbiotech | 200ul | EUR 540 |
Phospho-c-Myc (Ser62) Antibody |
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| AF3054 | Affbiotech | 200ul | EUR 420 |
TH (phospho Ser62) Polyclonal Antibody |
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| ES7384-100ul | ELK Biotech | 100ul | EUR 334.8 |
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Description: A Rabbit Polyclonal antibody against TH (phospho Ser62) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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TH (phospho Ser62) Polyclonal Antibody |
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| ES7384-50ul | ELK Biotech | 50ul | EUR 248.4 |
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Description: A Rabbit Polyclonal antibody against TH (phospho Ser62) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
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Ontwikkeling van een peptide dat DNA-herstel remt door de binding van Artemis en DNA Ligase IV te blokkeren om de radiogevoeligheid van tumoren te verbeteren
Doel: Artemis en DNA-ligase IV zijn twee cruciale elementen in de NHEJ-route van DNA-herstel, die respectievelijk als nuclease en DNA-ligase fungeren. Verbeterde cellulaire stralingsgevoeligheid door remming van beide eiwitten draagt bij aan een veelbelovende benadering om moleculaire gerichte radiosensitizers te ontwikkelen. De interactie tussen Artemis en DNA Ligase IV is vereist voor de activering van Artemis als nuclease bij 3′-overhangend DNA; daarom willen we een remmend peptide genereren dat gericht is op de interactie tussen Artemis en DNA Ligase IV voor de ontwikkeling van nieuwe radiosensitizers.
Methoden: We hebben het peptide BAL gesynthetiseerd dat bestaat uit de interactieresiduen van Artemis met DNA-ligase IV. Het radiosensibilisatie-effect van BAL werd geëvalueerd door middel van een kolonievormingsassay. De effecten van BAL op door bestraling geïnduceerd DNA-herstel werden geëvalueerd met Western Blotting en immunofluorescentie. Effecten van BAL op celproliferatie, stopzetting van de celcyclus en celapoptose werden beoordeeld through CCK-Eight en flowcytometrie-assays. De mogelijke synergetische effecten van BAL en bestraling in vivo werden onderzocht in een xenograft muismodel.
Resultaten: Resultaten tonen aan dat het gegenereerde peptide BAL dat de interactie tussen Artemis en DNA Ligase IV blokkeert, de stralingsgevoeligheid van GBC-SD- en Hela-cellijnen important verhoogt. BAL verlengt DNA-herstel na bestraling; BAL en bestraling vertonen synergetische effecten op celproliferatie, celcyclus en celapoptose; en deze functies zijn allemaal gerelateerd aan DNA-ligase IV. Ten slotte hebben we het endogene radiosensibilisatie-effect van BAL in een xenograft-muismodel bevestigd.
Conclusies: Samenvattend, het remmende peptide BAL dat zich richt op Artemis en DNA Ligase IV-binding functioneert met succes als een nieuwe radiosensitizer die DNA-herstel vertraagt en synergiseert met bestraling om celproliferatie te remmen, celcyclusstilstand te induceren en celapoptose te bevorderen.
Een oraal beschikbare PD-1/PD-L1-blokkerende peptide OPBP-1-geladen trimethylchitosan-hydrogel voor immunotherapie van kanker
Blokkade van het immuuncontrolepunt PD-1/PD-L1 met monoklonale antilichamen toonde ongekende klinische werkzaamheid bij veel kankers. Maar de oraal beschikbare remmers met een laag molecuulgewicht blijven in de kinderschoenen. In vergelijking met kleine moleculen vertoont peptide een betere selectiviteit en minder bijwerkingen, maar een slechte halfwaardetijd en een grote uitdaging om oraal te worden toegediend. Hier hebben we een proteolyse-resistente D-peptide OPBP-1 (Oral PD-L1 Binding Peptide 1) ontwikkeld die selectief PD-L1 kan binden, PD-1/PD-L1-interactie important kan blokkeren en IFN-γ (interferon γ) secretie kan verbeteren van CD8 + T-cellen in menselijke PBMC’s (perifere mononucleaire bloedcellen). OPBP-1 zou de tumorgroei in muriene colorectale CT26- en melanoom B16-OVA-modellen important kunnen remmen bij een relatief lage dosis van 0,5 mg/kg, met verbetering van de infiltratie en functie van CD8 + T-cellen. Interessanter is dat orale afgifte van OPBP-1 geladen TMC (N, N, N-trimethylchitosan) hydrogel ( [email protected]) vertoonde een zeer goede orale biologische beschikbaarheid van OPBP-1 (52,8%) en verlengde halfwaardetijd (14,55 uur) bij ratten, en remde ook important de tumorgroei in het CT26-model. Concluderend hebben we een PD-1/PD-L1-blokkerend peptide OPBP-1 ontdekt en geoptimaliseerd, through en vervolgens geladen in een op TMC gebaseerd hydrogel oraal toedieningssysteem, om de orale biologische beschikbaarheid van het peptidegeneesmiddel maximaal te verhogen en de tumorgroei effectief te remmen. . Deze resultaten openden een nieuw perspectief voor de ontwikkeling van orale geneesmiddelen bij immunotherapie van kanker.
Intermoleculaire interactieanalyses op SARS-CoV-2 Spike Protein Receptor Binding Area en Human Angiotensine-Changing Enzyme 2 Receptor-blocking Antibody/Peptide met behulp van fragmentmoleculaire orbitale berekening
Het spike-glycoproteïne (S-proteïne) bemiddelt SARS-CoV-2 binnenkomst through intermoleculaire interactie met humaan angiotensine-converterend enzym 2. Het receptorbindende domein (RBD) van het S-proteïne wordt als cruciaal beschouwd voor deze interactie en fungeert als het doelwit van talrijke neutraliserende antilichamen en antivirale peptiden. Deze studie gebruikte de fragment moleculaire orbitale methode om de interacties tussen de RBD en antilichamen/peptiden te analyseren en cruciale residuen te extraheren die als epitopen kunnen worden gebruikt. De interacties geëvalueerd als interfragment interactie energiewaarden tussen de RBD en 12 antilichamen / peptiden toonden een redelijk goede correlatie met de experimentele activiteit pICso 50 ( R 2 = 0,540). Negen residuen (T415, Ok417, Y421, F456, A475, F486, N487, N501 en Y505) werden bevestigd als cruciaal. Analyses van de ontleding van de energie van een paar interacties toonden aan dat waterstofbruggen, elektrostatische interacties en π-orbitale interacties belangrijk zijn. Onze resultaten bieden essentiële informatie voor het begrijpen van SARS-CoV-2-antilichaam / peptide-binding en kunnen een rol spelen in het toekomstige ontwerp van antilichaam / antivirale geneesmiddelen.
Alpha-bungarotoxin, CF680r |
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| 9-00003 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF640r |
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| 9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF640r |
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| 9-00004 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin CF488a |
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| 9-00005 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF568 |
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| 9-00006 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin CF594 |
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| 9-00007 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-bungarotoxin, CF633 |
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| 9-00009 | Biotium |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin |
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| 00010-1 | Biotium | 1MG | EUR 201.6 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Fluorescein-Alpha-bungarotoxin |
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| 00011 | Biotium | 500uG | EUR 440.4 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Tetramethylrhodamine-Alpha-bungarotoxin |
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| 00012 | Biotium | 500uG | EUR 459.6 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Fluorescein-alpha-bungarotoxin: (10x50ug) |
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| 00013 | Biotium | 10ST | EUR 500.4 |
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Description: Minimum order quantity: 1 unit of 10ST |
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Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug) |
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| 00014 | Biotium | 10ST | EUR 559.2 |
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Description: Minimum order quantity: 1 unit of 10ST |
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Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug) |
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| 00015 | Biotium | 500uG | EUR 559.2 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug) |
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| 00016 | Biotium | 10ST | EUR 627.6 |
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Description: Minimum order quantity: 1 unit of 10ST |
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Biotin-xx-a-bungarotoxin |
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| 00017 | Biotium | 500uG | EUR 519.6 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 500uG |
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Alpha-Bungarotoxin, CF555 conjugate |
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| 9-00018 | Biotium |
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Description: Minimum order quantity: 1 unit of 100ug |
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Biotin-cAMP, diisopropylethylammonium salt: |
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| 00020 | Biotium | 1MG | EUR 376.8 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Biotin-cAMP, diisopropylethylammonium salt: (20x50ug) |
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| 00020-1 | Biotium | 20ST | EUR 501.6 |
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Description: Minimum order quantity: 1 unit of 20ST |
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Biotin-cGMP, diisopropylethylammonium salt: |
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| 00021 | Biotium | 1MG | EUR 412.8 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Biotin-cGMP, diisopropylethylammonium salt: (20x50ug) |
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| 00021-1 | Biotium | 20ST | EUR 537.6 |
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Description: Minimum order quantity: 1 unit of 20ST |
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Cyanine 644-cAMP: |
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| 00022 | Biotium | 1MG | EUR 589.2 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Cyanine 644-cAMP: (20x50ug) |
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| 00022-1 | Biotium | 20ST | EUR 750 |
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Description: Minimum order quantity: 1 unit of 20ST |
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Fluorescein Methotrexate, triammonium salt: |
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| 00023 | Biotium | 1MG | EUR 337.2 |
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Description: Minimum order quantity: 1 unit of 1MG |
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Staurosporine |
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| 00025 | Biotium | 100uG | EUR 166.8 |
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Description: Minimum order quantity: 1 unit of 100uG |
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Alpha-bungarotoxin, CF543 |
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| 00026 | Biotium | 500uG | EUR 592.8 |
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Description: Minimum order quantity: 1 unit of 500uG |
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Rhodamine phalloidin 300u |
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| 00027 | Biotium | 300 | EUR 414 |
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Description: Minimum order quantity: 1 unit of 300 |
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Biotin-xx-phalloidin |
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| 00028 | Biotium | 100U | EUR 513.6 |
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Description: Minimum order quantity: 1 unit of 100U |
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Fluorescein-phalloidin |
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| 00030 | Biotium | 300U | EUR 414 |
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Description: Minimum order quantity: 1 unit of 300U |
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Rhodamine 110 phalloidin |
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| 00032 | Biotium | 300ST | EUR 414 |
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Description: Minimum order quantity: 1 unit of 300ST |
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Sulforhodamine 101 (Texas-Red) Phalloidin |
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| 00033 | Biotium | 300EU | EUR 414 |
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Description: Minimum order quantity: 1 unit of 300EU |
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Phalloidin, CF405M |
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| 00034 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF405M |
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| 00034-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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CF488A-cAMP |
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| 00036 | Biotium | 100ug | EUR 206.4 |
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Description: Minimum order quantity: 1 unit of 100ug |
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CF640R-cAMP |
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| 00037 | Biotium | 100ug | EUR 206.4 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Phalloidin, CF555 |
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| 00040 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF555 |
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| 00040-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF647 |
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| 00041 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF647 |
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| 00041-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF488A |
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| 00042 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF488A |
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| 00042-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF543 |
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| 00043 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF543 |
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| 00043-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF568 |
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| 00044 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF568 |
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| 00044-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF594 |
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| 00045 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF594 |
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| 00045-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF633 |
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| 00046 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF633 |
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| 00046-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF660R |
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| 00047 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660R |
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| 00047-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF680R |
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| 00048 | Biotium | 300U | EUR 559.2 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680R |
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| 00048-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF350 |
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| 00049 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF350 |
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| 00049-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF640R |
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| 00050 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF640R |
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| 00050-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF532 |
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| 00051 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF532 |
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| 00051-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF660C |
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| 00052 | Biotium | 300U | EUR 530.4 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF660C |
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| 00052-T | Biotium | 50U | EUR 159.6 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF680 |
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| 00053 | Biotium | 300U | EUR 559.2 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF680 |
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| 00053-T | Biotium | 50U | EUR 176.4 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF430 |
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| 00054 | Biotium | 300U | EUR 538.8 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF430 |
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| 00054-T | Biotium | 50U | EUR 166.8 |
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Description: Minimum order quantity: 1 unit of 50U |
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Phalloidin, CF440 |
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| 00055 | Biotium | 300U | EUR 538.8 |
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Description: Minimum order quantity: 1 unit of 300U |
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Phalloidin, CF440 |
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| 00055-T | Biotium | 50U | EUR 166.8 |
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Description: Minimum order quantity: 1 unit of 50U |
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Cholera Toxin Subunit B, CF488A conjugate |
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| 00070 | Biotium | 100ug | EUR 313.2 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF568 conjugate |
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| 00071 | Biotium | 100ug | EUR 313.2 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF594 conjugate |
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| 00072 | Biotium | 100ug | EUR 313.2 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF640R conjugate |
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| 00073 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF532 conjugate |
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| 00074 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF543 conjugate |
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| 00075 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF620R conjugate |
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| 00076 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF633 conjugate |
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| 00077 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF660R conjugate |
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| 00078 | Biotium | 100ug | EUR 316.8 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Cholera Toxin Subunit B, CF680R conjugate |
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| 00079 | Biotium | 100ug | EUR 338.4 |
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Description: Minimum order quantity: 1 unit of 100ug |
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Human Transferrin, CF488A conjugate |
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| 00081 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF543 conjugate |
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| 00082 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF568 conjugate |
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| 00083 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF594 conjugate |
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| 00084 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF640R conjugate |
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| 00085 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF680R conjugate |
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| 00086 | Biotium | 1mg | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 1mg |
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Human Transferrin, CF750 conjugate |
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| 00087 | Biotium | 1mg | EUR 186 |
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Description: Minimum order quantity: 1 unit of 1mg |
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HIV-1 tat recombinant antigen |
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| 00110-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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HIV-1 tat recombinant antigen |
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| 00110-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV-1 tat recombinant antigen full length 15 kDa |
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HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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HIV-1 GAG P24 Recombinant Antigen |
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| 00111-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa |
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HIV-1 nef recombinant antigen |
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| 00112-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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HIV-1 nef recombinant antigen |
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| 00112-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa |
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HIV-1 env gp41 recombinant antigen |
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| 00113-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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HIV-1 env gp41 recombinant antigen |
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| 00113-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa |
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HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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HIV-2 GP 36 Recombinant Antigen |
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| 00114-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa |
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HCV core recombinant antigen |
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| 00115-V-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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HCV core recombinant antigen |
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| 00115-V-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa |
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HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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HCV core recombinant antigen, Biotin conjugate |
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| 00115-V-B-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate. |
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HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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HCV core recombinant antigen, FITC conjugate |
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| 00115-V-F-1000ug | Virogen | 1000 ug | EUR 1539 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate. |
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HCV core recombinant antigen, Rhodamine |
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| 00115-V-R-01mg | Virogen | 0,1 mg | EUR 321 |
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Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate. |
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