themoralbrain

Een nieuw bioengineered fragmentpeptide van Vasostatin-1

Een nieuw bioengineered fragmentpeptide van Vasostatin-1 oefent farmacologische activiteiten van gladde spieren en anti-angiogene effecten uit through het blokkeren van de VEGFR-signaleringsroute

Chromogranine A (CgA) is een hydrofiel glycoproteïne dat wordt afgegeven door postganglionaire sympathische neuronen. CgA bestaat uit een enkele peptideketen die talrijke gepaarde basische residuen bevat, die typische splitsingsplaatsen in prohormonen zijn om bioactieve peptiden te genereren. Het wordt erkend als een diagnostische en prognostische serummarker voor neuro-endocriene tumoren. Vasostatine-1 is een van de meest geconserveerde regio’s van CgA en heeft numerous remmende biologische activiteiten. In deze studie werd een nieuw peptidefragment gesynthetiseerd dat drie typische functionele structuren van Vasostatin-1 bevat. Dit unieke bioengineered Vasostatin-1 Derived Peptide (genaamd V1DP) omvat een sterk geconserveerd domein tussen gewervelde soorten in het N-terminale gebied, bestaande uit een disulfidebrug gevormd door twee cysteïneresiduen op respectievelijk aminozuurposities 17 en 38. Trouwens, V1DP bevat twee significante tripeptide-herkenningssequenties: de aminozuurtriplets, RGD en KGD. Onze gegevens toonden aan dat V1DP een dosisafhankelijke relaxatie van de arteriële gladde spier van de rat kon induceren en ook de contractie-activiteit van de gladde spier van de baarmoeder van de rat kon verhogen. Wat nog belangrijker is, we ontdekten dat V1DP de proliferatie van kankercellen remt, de HUVEC-celmigratie moduleert en een anti-angiogenese-effect vertoont, zowel in vitro  en in  vivo. 

We hebben het feitelijke mechanisme van V1DP verder onderzocht en onze resultaten bevestigden dat V1DP de vasculaire endotheliale groeifactorreceptor (VEGFR) -signalering remt. We koppelden V1DP aan de apo-structuren van VEGFR2 en onderzochten de stabiliteit van het peptide in de eiwitpockets. Onze simulatie- en vrije-energieberekeningen gaven aan dat V1DP kan binden aan het katalytische domein en regulatoire domeinzakken, afhankelijk van of de conformationele toestand van het eiwit JM-in of JM-out is. Al met al suggereerden onze gegevens dat V1DP een rol speelt als regulator van de endotheelcelfunctie en farmacologische homeostase van gladde spieren. V1DP is een in water oplosbaar en biologisch stabiel peptide en zou zich verder kunnen ontwikkelen als een anti-angiogeen geneesmiddel voor de behandeling van kanker.

themoralbrain
themoralbrain

 

 

 

 

 

 

 

 

BCL-XL (Phospho-Ser62) Polyclonal Conjugated Antibody

C11066 100ul
EUR 397

Phospho-BCL-XL (Thr47) Blocking Peptide

AF3414-BP 1mg
EUR 195

BCL-XL Blocking Peptide

AF6414-BP 1mg
EUR 195

BCL-XL Blocking Peptide

AF6415-BP 1mg
EUR 195

Bcl-xL Blocking Peptide

3312BP-50
EUR 153

Bcl xL Blocking Peptide

33R-10466 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bcl xL antibody, catalog no. 20R-1516

Bcl-xL Blocking Peptide

33R-10707 50 ug
EUR 191
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bcl-xL antibody, catalog no. 70R-11750

Polyclonal BCL2L1 / BCL-XL Antibody (Ser62)

APG02242G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BCL2L1 / BCL-XL (Ser62). This antibody is tested and proven to work in the following applications:

BCL-XL (Phospho-Ser62) Colorimetric Cell-Based ELISA Kit

EKC2364 100ul
EUR 572

Bcl-xL Peptide

3341P 0.05 mg
EUR 164.75
Description: (CT) Bcl-xL peptide

Phospho-Myc (Ser62) Blocking Peptide

AF3054-BP 1mg
EUR 195

Phospho-BCL-XL (Ser62) Colorimetric Cell-Based ELISA Kit (OKAG01898)

OKAG01898 2 x 96 Wells
EUR 740
Description: Description of target: ;Species reactivity: Human: S62, Mouse: S62, Rat: S62;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: Phospho
Detection Method: Colorimetric 450 nm;Sensitivity:

Phospho-BCL-XL (Thr47) Antibody

AF3414 200ul
EUR 304
Description: Phospho-BCL-XL (Thr47) Antibody detects endogenous levels of BCL-XL only when phosphorylated at Threonine 47.

Phospho- BCL- XL (Thr47) Antibody

ABF3414 100 ug
EUR 438

Phospho-ATF2 (Ser62/44) Blocking Peptide

AF3176-BP 1mg
EUR 195

Bcl-x (phospho Ser62) Polyclonal Antibody

ES7034-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Bcl-x (phospho Ser62) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Bcl-x (phospho Ser62) Polyclonal Antibody

ES7034-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Bcl-x (phospho Ser62) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Bcl-x (phospho Ser62) Polyclonal Antibody

ABP56035-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Bcl-x phospho Ser62) from Human, Mouse, Rat. This Bcl-x phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Bcl-x around the phosphorylation site of S62

Bcl-x (phospho Ser62) Polyclonal Antibody

ABP56035-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Bcl-x phospho Ser62) from Human, Mouse, Rat. This Bcl-x phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Bcl-x around the phosphorylation site of S62

Bcl-x (phospho Ser62) Polyclonal Antibody

ABP56035-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Bcl-x phospho Ser62) from Human, Mouse, Rat. This Bcl-x phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Bcl-x around the phosphorylation site of S62

Bcl-xL Antibody

24247-100ul 100ul
EUR 390

Bcl-XL Antibody

48688-100ul 100ul
EUR 333

Bcl-XL Antibody

48688-50ul 50ul
EUR 239

BCL-XL Antibody

AF6414 200ul
EUR 304
Description: BCL-XL Antibody detects endogenous levels of total BCL-XL.

BCL-XL Antibody

AF6415 200ul
EUR 304
Description: BCL-XL Antibody detects endogenous levels of total BCL-XL.

BCL- XL Antibody

ABF6414 100 ug
EUR 438

BCL- XL Antibody

ABF6415 100 ug
EUR 438

Bcl-xL Antibody

3312-100
EUR 359

Bcl-xL Antibody

3312-30T
EUR 146

BCL XL antibody

20R-2242 50 ug
EUR 281
Description: Rabbit polyclonal BCL XL antibody

Bcl xL antibody

20R-1516 100 ug
EUR 651
Description: Rabbit polyclonal Bcl xL antibody

Bcl-xL Antibody

3341-002mg 0.02 mg
EUR 171.82
Description: Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.

Bcl-xL Antibody

3341-01mg 0.1 mg
EUR 436.42
Description: Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.

Bcl-xL antibody

70R-11750 100 ug
EUR 470
Description: Rabbit polyclonal Bcl-xL antibody

Bcl-xL antibody

70R-21426 50 ul
EUR 435
Description: Rabbit polyclonal Bcl-xL antibody

BCL-XL antibody

70R-34417 100 ug
EUR 327
Description: Rabbit polyclonal BCL-XL antibody

Phospho-ENSA (Ser67) /ARPP19 (Ser62) Blocking Peptide

AF4381-BP 1mg
EUR 195

Bcl-Xl Polyclonal Antibody

ES8287-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/Mouse/Rat. This antibody is tested and validated for IHC

Bcl-Xl Polyclonal Antibody

ES8287-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/Mouse/Rat. This antibody is tested and validated for IHC

Bcl-Xl Polyclonal Antibody

EA258-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

Bcl-Xl Polyclonal Antibody

EA258-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

BCL-XL (pS62) Antibody

20-abx119182
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

BCL-XL (pT115) Antibody

20-abx119349
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

BCL-XL (pS62) Antibody

abx011693-100ug 100 ug
EUR 439

BCL-XL (pT47) Antibody

abx011695-100ug 100 ug
EUR 439

Bcl-Xl Polyclonal Antibody

ABP57290-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Bcl-Xl from Human, Mouse, Rat. This Bcl-Xl antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

Bcl-Xl Polyclonal Antibody

ABP57290-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Bcl-Xl from Human, Mouse, Rat. This Bcl-Xl antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

Bcl-Xl Polyclonal Antibody

ABP57290-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Bcl-Xl from Human, Mouse, Rat. This Bcl-Xl antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

Anti-Bcl-Xl antibody

STJ97501 200 µl
EUR 197
Description: Rabbit polyclonal to Bcl-Xl.

Mouse Bcl-XL Antibody

35630-05111 150 ug
EUR 261

Bcl-XL Conjugated Antibody

C48688 100ul
EUR 397

Polyclonal Bcl-xL Antibody

APG02228G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Bcl-xL . This antibody is tested and proven to work in the following applications:

Polyclonal Bcl-xL Antibody

APG02229G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Bcl-xL . This antibody is tested and proven to work in the following applications:

BCL-XL antibody (Thr115)

70R-34416 100 ug
EUR 327
Description: Rabbit polyclonal BCL-XL antibody (Thr115)

Bcl-xl protein

E20-80114 20ug
EUR 408

Bcl-xl protein

E20-80115 20ug
EUR 408

Phospho-BCL-3 (Ser41) Blocking Peptide

AF7256-BP 1mg
EUR 195

Phospho-BCL-10 (Ser138) Blocking Peptide

AF8215-BP 1mg
EUR 195

Phospho-Bcl-6 (Ser343) Blocking Peptide

AF8244-BP 1mg
EUR 195

Phospho-BCL-2 (Thr74) Blocking Peptide

AF8465-BP 1mg
EUR 195

Phospho-BCL-3 (Ser402) Blocking Peptide

AF8466-BP 1mg
EUR 195

Phospho-BCL-2 (Ser87) Blocking Peptide

AF3138-BP 1mg
EUR 195

Phospho-BCL-2 (Thr69) Blocking Peptide

AF3139-BP 1mg
EUR 195

Phospho-BCL-2 (Ser70) Blocking Peptide

AF3140-BP 1mg
EUR 195

Phospho-Bcl-2 (Thr56) Blocking Peptide

AF4400-BP 1mg
EUR 195

Apoptosis Regulator Bcl-X (BCL-XL) Antibody

20-abx011694
  • EUR 439.00
  • EUR 91.00
  • 100 ug
  • 10 ug

Apoptosis Regulator Bcl-X (BCL-XL) Antibody

abx011696-100ug 100 ug
EUR 439

Apoptosis Regulator Bcl-X (BCL-XL) Antibody

abx412040-01mg 0.1 mg
EUR 509

Anti-Bcl-XL/BCL2L1 Antibody

A00181 100ug/vial
EUR 334

BCL-XL (Ab-62) Antibody

21061-100ul 100ul
EUR 252

BCL-XL (Ab-62) Antibody

21061-50ul 50ul
EUR 187

Bcl-XL recombinant monoclonal antibody

A5091 100ul X 3
EUR 595
Description: A recombinant monoclonal antibody from rabbit against human Bcl-XL for WB, IHC,ELISA

Bcl-XL Rabbit mAb

A19703-100ul 100 ul
EUR 410

Bcl-XL Rabbit mAb

A19703-200ul 200 ul
EUR 571

Bcl-XL Rabbit mAb

A19703-20ul 20 ul
EUR 221

Bcl-XL Rabbit mAb

A19703-50ul 50 ul
EUR 287

pCDH- puro- Bcl- XL

PVT10290 2 ug
EUR 301

Bcl-xL Recombinant Protein

91-087 0.05 mg
EUR 542.75
Description: Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.

STMN1 (Phospho-Ser62) Antibody

20-abx012587
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Myc (Phospho-Ser62) Antibody

11311-100ul 100ul
EUR 252

Myc (Phospho-Ser62) Antibody

11311-50ul 50ul
EUR 187

Phospho-MYC (Ser62) Antibody

CSB-PA062361-
EUR 335
Description: A polyclonal antibody against Phospho-MYC (Ser62). Recognizes Phospho-MYC (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200

Phospho-MYC (Ser62) Antibody

CSB-PA062361-100ul 100ul
EUR 362
Description: A polyclonal antibody against Phospho-MYC (Ser62). Recognizes Phospho-MYC (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200

Phospho-BCL2L1 (Ser62) Antibody

CSB-PA786016-
EUR 335
Description: A polyclonal antibody against Phospho-BCL2L1 (Ser62). Recognizes Phospho-BCL2L1 (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;

Phospho-BCL2L1 (Ser62) Antibody

CSB-PA786016-100ul 100ul
EUR 362
Description: A polyclonal antibody against Phospho-BCL2L1 (Ser62). Recognizes Phospho-BCL2L1 (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;

Phospho-Myc (Ser62) Antibody

AF3054 200ul
EUR 304
Description: Phospho-Myc (Ser62) Antibody detects endogenous levels of Myc only when phosphorylated at Serine 62.

Phospho- Myc (Ser62) Antibody

ABF3054 100 ug
EUR 438

BCL-2 Blocking Peptide

AF6139-BP 1mg
EUR 195

BCL-3 Blocking Peptide

AF7756-BP 1mg
EUR 195

Bcl-2 Blocking Peptide

BF9103-BP 1mg
EUR 195

BCL-2 Blocking Peptide

AF0769-BP 1mg
EUR 195

Bcl-2 Blocking Peptide

AF4700-BP 1mg
EUR 195

BCL-3 Blocking Peptide

DF10317-BP 1mg
EUR 195

Bcl-3 Blocking Peptide

3407BP-50
EUR 153

Ontwikkeling van een peptide dat DNA-herstel remt door de binding van Artemis en DNA Ligase IV te blokkeren om de radiogevoeligheid van tumoren te verbeteren

Doel:  Artemis en DNA-ligase IV zijn twee cruciale elementen in de NHEJ-route van DNA-herstel, die respectievelijk als nuclease en DNA-ligase fungeren. Verbeterde cellulaire stralingsgevoeligheid door remming van beide eiwitten draagt ​​bij aan een veelbelovende benadering om moleculaire gerichte radiosensitizers te ontwikkelen. De interactie tussen Artemis en DNA Ligase IV is vereist voor de activering van Artemis als nuclease bij 3′-overhangend DNA; daarom willen we een remmend peptide genereren dat gericht is op de interactie tussen Artemis en DNA Ligase IV voor de ontwikkeling van nieuwe radiosensitizers.

Methoden:  We hebben het peptide BAL gesynthetiseerd dat bestaat uit de interactieresiduen van Artemis met DNA-ligase IV. Het radiosensibilisatie-effect van BAL werd geëvalueerd door middel van een kolonievormingsassay. De effecten van BAL op door bestraling geïnduceerd DNA-herstel werden geëvalueerd met Western Blotting en immunofluorescentie. Effecten van BAL op celproliferatie, stopzetting van de celcyclus en celapoptose werden beoordeeld through CCK-Eight en flowcytometrie-assays. De mogelijke synergetische effecten van BAL en bestraling in vivo werden onderzocht in een xenograft muismodel.

Resultaten:  Resultaten tonen aan dat het gegenereerde peptide BAL dat de interactie tussen Artemis en DNA Ligase IV blokkeert, de stralingsgevoeligheid van GBC-SD- en Hela-cellijnen important verhoogt. BAL verlengt DNA-herstel na bestraling; BAL en bestraling vertonen synergetische effecten op celproliferatie, celcyclus en celapoptose; en deze functies zijn allemaal gerelateerd aan DNA-ligase IV. Ten slotte hebben we het endogene radiosensibilisatie-effect van BAL in een xenograft-muismodel bevestigd.

Conclusies:  Samenvattend, het remmende peptide BAL dat zich richt op Artemis en DNA Ligase IV-binding functioneert met succes als een nieuwe radiosensitizer die DNA-herstel vertraagt ​​en synergiseert met bestraling om celproliferatie te remmen, celcyclusstilstand te induceren en celapoptose te bevorderen.

Een oraal beschikbare PD-1/PD-L1-blokkerende peptide OPBP-1-geladen trimethylchitosan-hydrogel voor immunotherapie van kanker

Blokkade van het immuuncontrolepunt PD-1/PD-L1 met monoklonale antilichamen toonde ongekende klinische werkzaamheid bij veel kankers. Maar de oraal beschikbare remmers met een laag molecuulgewicht blijven in de kinderschoenen. In vergelijking met kleine moleculen vertoont peptide een betere selectiviteit en minder bijwerkingen, maar een slechte halfwaardetijd en een grote uitdaging om oraal te worden toegediend. Hier hebben we een proteolyse-resistente D-peptide OPBP-1 (Oral PD-L1 Binding Peptide 1) ontwikkeld die selectief PD-L1 kan binden, PD-1/PD-L1-interactie important kan blokkeren en IFN-γ (interferon γ) secretie kan verbeteren van CD8 + T-cellen in menselijke PBMC’s (perifere mononucleaire bloedcellen). OPBP-1 zou de tumorgroei in muriene colorectale CT26- en melanoom B16-OVA-modellen important kunnen remmen bij een relatief lage dosis van 0,5 mg/kg, met verbetering van de infiltratie en functie van CD8 +  T-cellen. Interessanter is dat orale afgifte van OPBP-1 geladen TMC (N, N, N-trimethylchitosan) hydrogel ( [email protected]) vertoonde een zeer goede orale biologische beschikbaarheid van OPBP-1 (52,8%) en verlengde halfwaardetijd (14,55 uur) bij ratten, en remde ook important de tumorgroei in het CT26-model. Concluderend hebben we een PD-1/PD-L1-blokkerend peptide OPBP-1 ontdekt en geoptimaliseerd, through en vervolgens geladen in een op TMC gebaseerd hydrogel oraal toedieningssysteem, om de orale biologische beschikbaarheid van het peptidegeneesmiddel maximaal te verhogen en de tumorgroei effectief te remmen. . Deze resultaten openden een nieuw perspectief voor de ontwikkeling van orale geneesmiddelen bij immunotherapie van kanker.

Intermoleculaire interactieanalyses op SARS-CoV-2 Spike Protein Receptor Binding Area en Human Angiotensine-Changing Enzyme 2 Receptor-blocking Antibody/Peptide met behulp van fragmentmoleculaire orbitale berekening

Het spike-glycoproteïne (S-proteïne) bemiddelt SARS-CoV-2 binnenkomst through intermoleculaire interactie met humaan angiotensine-converterend enzym 2. Het receptorbindende domein (RBD) van het S-proteïne wordt als cruciaal beschouwd voor deze interactie en fungeert als het doelwit van talrijke neutraliserende antilichamen en antivirale peptiden. Deze studie gebruikte de fragment moleculaire orbitale methode om de interacties tussen de RBD en antilichamen/peptiden te analyseren en cruciale residuen te extraheren die als epitopen kunnen worden gebruikt. De interacties geëvalueerd als interfragment interactie energiewaarden tussen de RBD en 12 antilichamen / peptiden toonden een redelijk goede correlatie met de experimentele activiteit pICso 50  ( 2 = 0,540). Negen residuen (T415, Ok417, Y421, F456, A475, F486, N487, N501 en Y505) werden bevestigd als cruciaal. Analyses van de ontleding van de energie van een paar interacties toonden aan dat waterstofbruggen, elektrostatische interacties en π-orbitale interacties belangrijk zijn. Onze resultaten bieden essentiële informatie voor het begrijpen van SARS-CoV-2-antilichaam / peptide-binding en kunnen een rol spelen in het toekomstige ontwerp van antilichaam / antivirale geneesmiddelen.

Alpha-bungarotoxin, CF680r

9-00003
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF640r

9-00004
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF640r

9-00004
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF488a

9-00005
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF488a

9-00005
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF568

9-00006
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF568

9-00006
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF594

9-00007
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF594

9-00007
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF633

9-00009
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF633

9-00009
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin

00010-1 1MG
EUR 168
Description: Minimum order quantity: 1 unit of 1MG

Fluorescein-Alpha-bungarotoxin

00011 500uG
EUR 367
Description: Minimum order quantity: 1 unit of 500uG

Tetramethylrhodamine-Alpha-bungarotoxin

00012 500uG
EUR 383
Description: Minimum order quantity: 1 unit of 500uG

Fluorescein-alpha-bungarotoxin: (10x50ug)

00013 10ST
EUR 417
Description: Minimum order quantity: 1 unit of 10ST

Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug)

00014 10ST
EUR 466
Description: Minimum order quantity: 1 unit of 10ST

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug)

00015 500uG
EUR 466
Description: Minimum order quantity: 1 unit of 500uG

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug)

00016 10ST
EUR 523
Description: Minimum order quantity: 1 unit of 10ST

Biotin-xx-a-bungarotoxin

00017 500uG
EUR 433
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate

9-00018
  • EUR 494.00
  • EUR 161.00
  • 500uG
  • 100ug
Description: Minimum order quantity: 1 unit of 100ug

Biotin-cAMP, diisopropylethylammonium salt:

00020 1MG
EUR 314
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cAMP, diisopropylethylammonium salt: (20x50ug)

00020-1 20ST
EUR 418
Description: Minimum order quantity: 1 unit of 20ST

Biotin-cGMP, diisopropylethylammonium salt:

00021 1MG
EUR 344
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cGMP, diisopropylethylammonium salt: (20x50ug)

00021-1 20ST
EUR 448
Description: Minimum order quantity: 1 unit of 20ST

Cyanine 644-cAMP:

00022 1MG
EUR 491
Description: Minimum order quantity: 1 unit of 1MG

Cyanine 644-cAMP: (20x50ug)

00022-1 20ST
EUR 625
Description: Minimum order quantity: 1 unit of 20ST

Fluorescein Methotrexate, triammonium salt:

00023 1MG
EUR 281
Description: Minimum order quantity: 1 unit of 1MG

Staurosporine

00025 100uG
EUR 139
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF543

00026 500uG
EUR 494
Description: Minimum order quantity: 1 unit of 500uG

Rhodamine phalloidin 300u

00027 300
EUR 345
Description: Minimum order quantity: 1 unit of 300

Biotin-xx-phalloidin

00028 100U
EUR 428
Description: Minimum order quantity: 1 unit of 100U

Fluorescein-phalloidin

00030 300U
EUR 345
Description: Minimum order quantity: 1 unit of 300U

Rhodamine 110 phalloidin

00032 300ST
EUR 345
Description: Minimum order quantity: 1 unit of 300ST

Sulforhodamine 101 (Texas-Red) Phalloidin

00033 300EU
EUR 345
Description: Minimum order quantity: 1 unit of 300EU

Phalloidin, CF405M

00034 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF405M

00034-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

CF488A-cAMP

00036 100ug
EUR 172
Description: Minimum order quantity: 1 unit of 100ug

CF640R-cAMP

00037 100ug
EUR 172
Description: Minimum order quantity: 1 unit of 100ug

Phalloidin, CF555

00040 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555

00040-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF647

00041 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF647

00041-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF488A

00042 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF488A

00042-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF543

00043 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF543

00043-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF568

00044 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF568

00044-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF594

00045 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF594

00045-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF633

00046 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF633

00046-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660R

00047 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660R

00047-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680R

00048 300U
EUR 466
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680R

00048-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF350

00049 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF350

00049-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF640R

00050 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF640R

00050-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF532

00051 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF532

00051-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660C

00052 300U
EUR 442
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660C

00052-T 50U
EUR 133
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680

00053 300U
EUR 466
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680

00053-T 50U
EUR 147
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF430

00054 300U
EUR 449
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF430

00054-T 50U
EUR 139
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF440

00055 300U
EUR 449
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF440

00055-T 50U
EUR 139
Description: Minimum order quantity: 1 unit of 50U

Cholera Toxin Subunit B, CF488A conjugate

00070 100ug
EUR 261
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF568 conjugate

00071 100ug
EUR 261
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF594 conjugate

00072 100ug
EUR 261
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF640R conjugate

00073 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF532 conjugate

00074 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF543 conjugate

00075 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF620R conjugate

00076 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF633 conjugate

00077 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF660R conjugate

00078 100ug
EUR 264
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF680R conjugate

00079 100ug
EUR 282
Description: Minimum order quantity: 1 unit of 100ug

Human Transferrin, CF488A conjugate

00081 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF543 conjugate

00082 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF568 conjugate

00083 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF594 conjugate

00084 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF640R conjugate

00085 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF680R conjugate

00086 1mg
EUR 149
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF750 conjugate

00087 1mg
EUR 155
Description: Minimum order quantity: 1 unit of 1mg

HIV-1 tat recombinant antigen

00110-V-01mg 0,1 mg
EUR 267.5
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 tat recombinant antigen

00110-V-1000ug 1000 ug
EUR 1282.5
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-01mg 0,1 mg
EUR 267.5
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-1000ug 1000 ug
EUR 1282.5
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 nef recombinant antigen

00112-V-01mg 0,1 mg
EUR 267.5
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 nef recombinant antigen

00112-V-1000ug 1000 ug
EUR 1282.5
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 env gp41 recombinant antigen

00113-V-01mg 0,1 mg
EUR 267.5
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 env gp41 recombinant antigen

00113-V-1000ug 1000 ug
EUR 1282.5
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-2 GP 36 Recombinant Antigen

00114-V-01mg 0,1 mg
EUR 267.5
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HIV-2 GP 36 Recombinant Antigen

00114-V-1000ug 1000 ug
EUR 1282.5
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HCV core recombinant antigen

00115-V-01mg 0,1 mg
EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen

00115-V-1000ug 1000 ug
EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen, Biotin conjugate

00115-V-B-01mg 0,1 mg
EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, Biotin conjugate

00115-V-B-1000ug 1000 ug
EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, FITC conjugate

00115-V-F-01mg 0,1 mg
EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, FITC conjugate

00115-V-F-1000ug 1000 ug
EUR 1282.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, Rhodamine

00115-V-R-01mg 0,1 mg
EUR 267.5
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.

Leave a Reply

Your email address will not be published.