Een nieuw bioengineered fragmentpeptide van Vasostatin-1 oefent farmacologische activiteiten van gladde spieren en anti-angiogene effecten uit through het blokkeren van de VEGFR-signaleringsroute

Chromogranine A (CgA) is een hydrofiel glycoproteïne dat wordt afgegeven door postganglionaire sympathische neuronen. CgA bestaat uit een enkele peptideketen die talrijke gepaarde basische residuen bevat, die typische splitsingsplaatsen in prohormonen zijn om bioactieve peptiden te genereren. Het wordt erkend als een diagnostische en prognostische serummarker voor neuro-endocriene tumoren. Vasostatine-1 is een van de meest geconserveerde regio’s van CgA en heeft numerous remmende biologische activiteiten. In deze studie werd een nieuw peptidefragment gesynthetiseerd dat drie typische functionele structuren van Vasostatin-1 bevat. Dit unieke bioengineered Vasostatin-1 Derived Peptide (genaamd V1DP) omvat een sterk geconserveerd domein tussen gewervelde soorten in het N-terminale gebied, bestaande uit een disulfidebrug gevormd door twee cysteïneresiduen op respectievelijk aminozuurposities 17 en 38. Trouwens, V1DP bevat twee significante tripeptide-herkenningssequenties: de aminozuurtriplets, RGD en KGD. Onze gegevens toonden aan dat V1DP een dosisafhankelijke relaxatie van de arteriële gladde spier van de rat kon induceren en ook de contractie-activiteit van de gladde spier van de baarmoeder van de rat kon verhogen. Wat nog belangrijker is, we ontdekten dat V1DP de proliferatie van kankercellen remt, de HUVEC-celmigratie moduleert en een anti-angiogenese-effect vertoont, zowel in vitro  en in  vivo. 

We hebben het feitelijke mechanisme van V1DP verder onderzocht en onze resultaten bevestigden dat V1DP de vasculaire endotheliale groeifactorreceptor (VEGFR) -signalering remt. We koppelden V1DP aan de apo-structuren van VEGFR2 en onderzochten de stabiliteit van het peptide in de eiwitpockets. Onze simulatie- en vrije-energieberekeningen gaven aan dat V1DP kan binden aan het katalytische domein en regulatoire domeinzakken, afhankelijk van of de conformationele toestand van het eiwit JM-in of JM-out is. Al met al suggereerden onze gegevens dat V1DP een rol speelt als regulator van de endotheelcelfunctie en farmacologische homeostase van gladde spieren. V1DP is een in water oplosbaar en biologisch stabiel peptide en zou zich verder kunnen ontwikkelen als een anti-angiogeen geneesmiddel voor de behandeling van kanker.

 

 

 

 

 

 

 

 

BCL-XL (Phospho-Ser62) Polyclonal Conjugated Antibody
C11066	SAB	100ul	EUR 476.4

Phospho-BCL-XL (Thr47) Blocking Peptide
AF3414-BP	Affbiotech	1mg	EUR 234

Bcl-xL Blocking Peptide
33R-10707	Fitzgerald	50 ug	EUR 229.2
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bcl-xL antibody, catalog no. 70R-11750

Bcl xL Blocking Peptide
33R-10466	Fitzgerald	50 ug	EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bcl xL antibody, catalog no. 20R-1516

BCL-XL Blocking Peptide
AF6414-BP	Affbiotech	1mg	EUR 234

BCL-XL Blocking Peptide
AF6415-BP	Affbiotech	1mg	EUR 234

Bcl-xL Blocking Peptide
3312BP-50	Biovision	each	EUR 183.6

Polyclonal BCL2L1 / BCL-XL Antibody (Ser62)
APG02242G	Leading Biology	0.05mg	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human BCL2L1 / BCL-XL (Ser62). This antibody is tested and proven to work in the following applications:

BCL-XL (Phospho-Ser62) Colorimetric Cell-Based ELISA Kit
EKC2364	BosterBio	100ul	EUR 686.4

Phospho-Myc (Ser62) Blocking Peptide
AF3054-BP	Affbiotech	1mg	EUR 234

Bcl-xL Peptide
3341P	ProSci	0.05 mg	EUR 197.7
Description: (CT) Bcl-xL peptide

Phospho-BCL-XL (Ser62) Colorimetric Cell-Based ELISA Kit (OKAG01898)
OKAG01898	Aviva Systems Biology	2 x 96 Wells	EUR 888
Description: Description of target: ;Species reactivity: Human: S62, Mouse: S62, Rat: S62;Application: ELISA;Assay info: Assay Type: Cell-Based Subtype: Phospho Detection Method: Colorimetric 450 nm;Sensitivity:

Phospho-ATF2 (Ser62/44) Blocking Peptide
AF3176-BP	Affbiotech	1mg	EUR 234

Phospho- BCL- XL (Thr47) Antibody
ABF3414	Lifescience Market	100 ug	EUR 525.6

Phospho-BCL-XL (Thr47) Antibody
AF3414	Affbiotech	200ul	EUR 420

Bcl-x (phospho Ser62) Polyclonal Antibody
ABP56035-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Bcl-x phospho Ser62) from Human, Mouse, Rat. This Bcl-x phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Bcl-x around the phosphorylation site of S62

Bcl-x (phospho Ser62) Polyclonal Antibody
ABP56035-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Bcl-x phospho Ser62) from Human, Mouse, Rat. This Bcl-x phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Bcl-x around the phosphorylation site of S62

Bcl-x (phospho Ser62) Polyclonal Antibody
ABP56035-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Bcl-x phospho Ser62) from Human, Mouse, Rat. This Bcl-x phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Bcl-x around the phosphorylation site of S62

Bcl-x (phospho Ser62) Polyclonal Antibody
ES7034-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Bcl-x (phospho Ser62) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Bcl-x (phospho Ser62) Polyclonal Antibody
ES7034-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Bcl-x (phospho Ser62) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Phospho-ENSA (Ser67) /ARPP19 (Ser62) Blocking Peptide
AF4381-BP	Affbiotech	1mg	EUR 234

Bcl-xL antibody
70R-11750	Fitzgerald	100 ug	EUR 564
Description: Rabbit polyclonal Bcl-xL antibody

Bcl-xL antibody
70R-21426	Fitzgerald	50 ul	EUR 522
Description: Rabbit polyclonal Bcl-xL antibody

BCL-XL antibody
70R-34417	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal BCL-XL antibody

Bcl-XL Antibody
48688-100ul	SAB	100ul	EUR 399.6

Bcl-XL Antibody
48688-50ul	SAB	50ul	EUR 286.8

Bcl-xL Antibody
3341-002mg	ProSci	0.02 mg	EUR 206.18
Description: Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.

Bcl-xL Antibody
3341-01mg	ProSci	0.1 mg	EUR 523.7
Description: Bcl-xL Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis. These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene. Its high expression in tumors is correlated with advanced disease and poor prognosis. Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.

Bcl xL antibody
20R-1516	Fitzgerald	100 ug	EUR 781.2
Description: Rabbit polyclonal Bcl xL antibody

BCL XL antibody
20R-2242	Fitzgerald	50 ug	EUR 337.2
Description: Rabbit polyclonal BCL XL antibody

Bcl-xL Antibody
24247-100ul	SAB	100ul	EUR 468

BCL- XL Antibody
ABF6414	Lifescience Market	100 ug	EUR 525.6

BCL- XL Antibody
ABF6415	Lifescience Market	100 ug	EUR 525.6

BCL-XL Antibody
DF6015	Affbiotech	200ul	EUR 420

BCL-XL Antibody
AF6414	Affbiotech	200ul	EUR 420

BCL-XL Antibody
AF6415	Affbiotech	200ul	EUR 420

Bcl-XL Antibody
R32762	NSJ Bioreagents	100ug	EUR 419

Bcl-xL Antibody
3312-100	Biovision	each	EUR 430.8

Bcl-xL Antibody
3312-30T	Biovision	each	EUR 175.2

Phospho-BCL-3 (Ser41) Blocking Peptide
AF7256-BP	Affbiotech	1mg	EUR 234

Phospho-BCL-10 (Ser138) Blocking Peptide
AF8215-BP	Affbiotech	1mg	EUR 234

Phospho-Bcl-6 (Ser343) Blocking Peptide
AF8244-BP	Affbiotech	1mg	EUR 234

Phospho-BCL-2 (Thr74) Blocking Peptide
AF8465-BP	Affbiotech	1mg	EUR 234

Phospho-BCL-3 (Ser402) Blocking Peptide
AF8466-BP	Affbiotech	1mg	EUR 234

Phospho-BCL-2 (Ser87) Blocking Peptide
AF3138-BP	Affbiotech	1mg	EUR 234

Phospho-BCL-2 (Thr69) Blocking Peptide
AF3139-BP	Affbiotech	1mg	EUR 234

Phospho-BCL-2 (Ser70) Blocking Peptide
AF3140-BP	Affbiotech	1mg	EUR 234

Phospho-Bcl-2 (Thr56) Blocking Peptide
AF4400-BP	Affbiotech	1mg	EUR 234

BCL-XL antibody (Thr115)
70R-34416	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal BCL-XL antibody (Thr115)

Mouse Bcl-XL Antibody
35630-05111	AssayPro	150 ug	EUR 313.2

Bcl-Xl Polyclonal Antibody
ABP57290-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Bcl-Xl from Human, Mouse, Rat. This Bcl-Xl antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

Bcl-Xl Polyclonal Antibody
ABP57290-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Bcl-Xl from Human, Mouse, Rat. This Bcl-Xl antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

Bcl-Xl Polyclonal Antibody
ABP57290-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Bcl-Xl from Human, Mouse, Rat. This Bcl-Xl antibody is for IHC-P. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen recombinant protein

BCL-XL (pT115) Antibody
20-abx119349	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

BCL-XL (pS62) Antibody
20-abx119182	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

BCL-XL (pS62) Antibody
abx011693-100ug	Abbexa	100 ug	EUR 526.8

BCL-XL (pT47) Antibody
abx011695-100ug	Abbexa	100 ug	EUR 526.8

Bcl-XL Conjugated Antibody
C48688	SAB	100ul	EUR 476.4

Polyclonal Bcl-xL Antibody
APG02228G	Leading Biology	0.1 mg	EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Bcl-xL . This antibody is tested and proven to work in the following applications:

Polyclonal Bcl-xL Antibody
APG02229G	Leading Biology	0.1mg	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Bcl-xL . This antibody is tested and proven to work in the following applications:

Bcl-Xl Polyclonal Antibody
EA258-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

Bcl-Xl Polyclonal Antibody
EA258-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/ Rat/ Mouse. This antibody is tested and validated for IHC

Bcl-Xl Polyclonal Antibody
ES8287-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/Mouse/Rat. This antibody is tested and validated for IHC

Bcl-Xl Polyclonal Antibody
ES8287-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Bcl-Xl from Human/Mouse/Rat. This antibody is tested and validated for IHC

Anti-Bcl-Xl antibody
STJ97501	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Bcl-Xl.

Bcl-xl protein
E20-80114	EnoGene	20ug	EUR 489.6

Bcl-xl protein
E20-80115	EnoGene	20ug	EUR 489.6

Heating Element Assembly for BactiZapper XL Tilt (B1001-XL), 115V
B1001-XL-RA	Benchmark Scientific	1 each	EUR 241.7

Apoptosis Regulator Bcl-X (BCL-XL) Antibody
20-abx011694	Abbexa	EUR 526.80 EUR 109.20	100 ug 10 ug

Apoptosis Regulator Bcl-X (BCL-XL) Antibody
abx011696-100ug	Abbexa	100 ug	EUR 526.8

Apoptosis Regulator Bcl-X (BCL-XL) Antibody
abx412040-01mg	Abbexa	0.1 mg	EUR 610.8

BCL-XL (Ab-62) Antibody
21061-100ul	SAB	100ul	EUR 302.4

BCL-XL (Ab-62) Antibody
21061-50ul	SAB	50ul	EUR 224.4

Bcl-XL recombinant monoclonal antibody
A5091	Bimake	100ul X 3	EUR 714
Description: A recombinant monoclonal antibody from rabbit against human Bcl-XL for WB, IHC,ELISA

Anti-Bcl-XL/BCL2L1 Antibody
A00181	BosterBio	100ug/vial	EUR 400.8

Myc (Phospho-Ser62) Antibody
11311-100ul	SAB	100ul	EUR 302.4

Myc (Phospho-Ser62) Antibody
11311-50ul	SAB	50ul	EUR 224.4

STMN1 (Phospho-Ser62) Antibody
20-abx012587	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

Phospho- Myc (Ser62) Antibody
ABF3054	Lifescience Market	100 ug	EUR 525.6

Phospho-BCL2L1 (Ser62) Antibody
CSB-PA786016-100ul	Cusabio	100ul	EUR 434.4
Description: A polyclonal antibody against Phospho-BCL2L1 (Ser62). Recognizes Phospho-BCL2L1 (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;

Phospho-MYC (Ser62) Antibody
CSB-PA062361-100ul	Cusabio	100ul	EUR 434.4
Description: A polyclonal antibody against Phospho-MYC (Ser62). Recognizes Phospho-MYC (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200

Phospho-MYC (Ser62) Antibody
CSB-PA062361-	Cusabio	each	EUR 402
Description: A polyclonal antibody against Phospho-MYC (Ser62). Recognizes Phospho-MYC (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IF;WB:1:500-1:1000, IF:1:100-1:200

Phospho-BCL2L1 (Ser62) Antibody
CSB-PA786016-	Cusabio	each	EUR 402
Description: A polyclonal antibody against Phospho-BCL2L1 (Ser62). Recognizes Phospho-BCL2L1 (Ser62) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;

Bcl-xL Recombinant Protein
91-087	ProSci	0.05 mg	EUR 651.3
Description: Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.

Bcl-XL Rabbit mAb
A19703-100ul	Abclonal	100 ul	EUR 492

Bcl-XL Rabbit mAb
A19703-200ul	Abclonal	200 ul	EUR 685.2

Bcl-XL Rabbit mAb
A19703-20ul	Abclonal	20 ul	EUR 265.2

Bcl-XL Rabbit mAb
A19703-50ul	Abclonal	50 ul	EUR 344.4

pCDH- puro- Bcl- XL
PVT10290	Lifescience Market	2 ug	EUR 361.2

Bcl 6 Blocking Peptide
33R-10485	Fitzgerald	50 ug	EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of Bcl 6 antibody, catalog no. 20R-1556

BCL-3 Blocking Peptide
AF7756-BP	Affbiotech	1mg	EUR 234

Bcl-2 Blocking Peptide
BF9103-BP	Affbiotech	1mg	EUR 234

BCL-3 Blocking Peptide
DF10317-BP	Affbiotech	1mg	EUR 234

Bcl-2 Blocking Peptide
AF4700-BP	Affbiotech	1mg	EUR 234

BCL-2 Blocking Peptide
AF6139-BP	Affbiotech	1mg	EUR 234

BCL-2 Blocking Peptide
AF0769-BP	Affbiotech	1mg	EUR 234

Bcl-2 Blocking Peptide
3033BP-50	Biovision	each	EUR 183.6

Bcl-3 Blocking Peptide
3407BP-50	Biovision	each	EUR 183.6

Bcl-6 Blocking Peptide
3408BP-50	Biovision	each	EUR 183.6

Bcl-Rambo Blocking Peptide
3671BP-50	Biovision	each	EUR 183.6

Bcl-B Blocking Peptide
3695BP-50	Biovision	each	EUR 183.6

BactiZapper™ Tilt XL, MicroSterilizer with adjustable tilt angle, 115V
B1001-XL	Benchmark Scientific	1 each	EUR 626.6

Mouse Bcl-XL Antibody (Biotin Conjugate)
35630-05121	AssayPro	150 ug	EUR 442.8

Anti-Bcl-XL Rabbit Monoclonal Antibody
M00181-1	BosterBio	100ug/vial	EUR 476.4
Description: Rabbit Monoclonal Bcl-XL Antibody. Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D	Stressmarq	0.1ml	EUR 424.8
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is unconjugated.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-A390	Stressmarq	0.1ml	EUR 481.2
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 390.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-A488	Stressmarq	0.1ml	EUR 480
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 488.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-A565	Stressmarq	0.1ml	EUR 480
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 565.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-A594	Stressmarq	0.1ml	EUR 480
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 594.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-A633	Stressmarq	0.1ml	EUR 480
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 633.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-A655	Stressmarq	0.1ml	EUR 480
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 655.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-A680	Stressmarq	0.1ml	EUR 480
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 680.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-A700	Stressmarq	0.1ml	EUR 480
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to ATTO 700.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-ALP	Stressmarq	0.1ml	EUR 472.8
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Alkaline Phosphatase.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-APC	Stressmarq	0.1ml	EUR 478.8
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to APC .

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-APCCY7	Stressmarq	0.1ml	EUR 565.2
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to APC/Cy7.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-BI	Stressmarq	0.1ml	EUR 475.2
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Biotin.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-DY350	Stressmarq	0.1ml	EUR 496.8
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 350.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-DY405	Stressmarq	0.1ml	EUR 483.6
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 405.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-DY488	Stressmarq	0.1ml	EUR 471.6
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 488.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-DY594	Stressmarq	0.1ml	EUR 474
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 594.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-DY633	Stressmarq	0.1ml	EUR 468
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Dylight 633.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-FITC	Stressmarq	0.1ml	EUR 470.4
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to FITC.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-HRP	Stressmarq	0.1ml	EUR 465.6
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to HRP.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-P594	Stressmarq	0.1ml	EUR 488.4
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to PE/ATTO 594.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-PCP	Stressmarq	0.1ml	EUR 478.8
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to PerCP.

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-RPE	Stressmarq	0.1ml	EUR 476.4
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to RPE .

Antibody for Human Bcl-xL (pSer62)
SPC-1352D-STR	Stressmarq	0.1ml	EUR 477.6
Description: A polyclonal antibody for Bcl-xL (pSer62) from Human | Mouse | Rat. The antibody is produced in rabbit after immunization with human synthetic phospho-peptide from human Bcl-xL around the phosphorylation site of serine 62 (pSer62).. The Antibody is tested and validated for WB, IHC, ELISA assays with the following recommended dilutions: WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:5000). This Bcl-xL (pSer62) antibody is conjugated to Streptavidin.

TH (Phospho-Ser62) Polyclonal Antibody
12282-100ul	SAB	100ul	EUR 302.4

TH (Phospho-Ser62) Polyclonal Antibody
12282-50ul	SAB	50ul	EUR 224.4

Op18 (phospho Ser62) Polyclonal Antibody
ABP55090-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Op18 phospho Ser62) from Human, Mouse, Rat, Monkey. This Op18 phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Op18 around the phosphorylation site of S62

Op18 (phospho Ser62) Polyclonal Antibody
ABP55090-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Op18 phospho Ser62) from Human, Mouse, Rat, Monkey. This Op18 phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Op18 around the phosphorylation site of S62

Op18 (phospho Ser62) Polyclonal Antibody
ABP55090-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Op18 phospho Ser62) from Human, Mouse, Rat, Monkey. This Op18 phospho Ser62) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Op18 around the phosphorylation site of S62

Ontwikkeling van een peptide dat DNA-herstel remt door de binding van Artemis en DNA Ligase IV te blokkeren om de radiogevoeligheid van tumoren te verbeteren

Doel:  Artemis en DNA-ligase IV zijn twee cruciale elementen in de NHEJ-route van DNA-herstel, die respectievelijk als nuclease en DNA-ligase fungeren. Verbeterde cellulaire stralingsgevoeligheid door remming van beide eiwitten draagt ​​bij aan een veelbelovende benadering om moleculaire gerichte radiosensitizers te ontwikkelen. De interactie tussen Artemis en DNA Ligase IV is vereist voor de activering van Artemis als nuclease bij 3′-overhangend DNA; daarom willen we een remmend peptide genereren dat gericht is op de interactie tussen Artemis en DNA Ligase IV voor de ontwikkeling van nieuwe radiosensitizers.

Methoden:  We hebben het peptide BAL gesynthetiseerd dat bestaat uit de interactieresiduen van Artemis met DNA-ligase IV. Het radiosensibilisatie-effect van BAL werd geëvalueerd door middel van een kolonievormingsassay. De effecten van BAL op door bestraling geïnduceerd DNA-herstel werden geëvalueerd met Western Blotting en immunofluorescentie. Effecten van BAL op celproliferatie, stopzetting van de celcyclus en celapoptose werden beoordeeld through CCK-Eight en flowcytometrie-assays. De mogelijke synergetische effecten van BAL en bestraling in vivo werden onderzocht in een xenograft muismodel.

Resultaten:  Resultaten tonen aan dat het gegenereerde peptide BAL dat de interactie tussen Artemis en DNA Ligase IV blokkeert, de stralingsgevoeligheid van GBC-SD- en Hela-cellijnen important verhoogt. BAL verlengt DNA-herstel na bestraling; BAL en bestraling vertonen synergetische effecten op celproliferatie, celcyclus en celapoptose; en deze functies zijn allemaal gerelateerd aan DNA-ligase IV. Ten slotte hebben we het endogene radiosensibilisatie-effect van BAL in een xenograft-muismodel bevestigd.

Conclusies:  Samenvattend, het remmende peptide BAL dat zich richt op Artemis en DNA Ligase IV-binding functioneert met succes als een nieuwe radiosensitizer die DNA-herstel vertraagt ​​en synergiseert met bestraling om celproliferatie te remmen, celcyclusstilstand te induceren en celapoptose te bevorderen.

Een oraal beschikbare PD-1/PD-L1-blokkerende peptide OPBP-1-geladen trimethylchitosan-hydrogel voor immunotherapie van kanker

Blokkade van het immuuncontrolepunt PD-1/PD-L1 met monoklonale antilichamen toonde ongekende klinische werkzaamheid bij veel kankers. Maar de oraal beschikbare remmers met een laag molecuulgewicht blijven in de kinderschoenen. In vergelijking met kleine moleculen vertoont peptide een betere selectiviteit en minder bijwerkingen, maar een slechte halfwaardetijd en een grote uitdaging om oraal te worden toegediend. Hier hebben we een proteolyse-resistente D-peptide OPBP-1 (Oral PD-L1 Binding Peptide 1) ontwikkeld die selectief PD-L1 kan binden, PD-1/PD-L1-interactie important kan blokkeren en IFN-γ (interferon γ) secretie kan verbeteren van CD8 ⁺ T-cellen in menselijke PBMC’s (perifere mononucleaire bloedcellen). OPBP-1 zou de tumorgroei in muriene colorectale CT26- en melanoom B16-OVA-modellen important kunnen remmen bij een relatief lage dosis van 0,5 mg/kg, met verbetering van de infiltratie en functie van CD8 ⁺  T-cellen. Interessanter is dat orale afgifte van OPBP-1 geladen TMC (N, N, N-trimethylchitosan) hydrogel ( [email protected]) vertoonde een zeer goede orale biologische beschikbaarheid van OPBP-1 (52,8%) en verlengde halfwaardetijd (14,55 uur) bij ratten, en remde ook important de tumorgroei in het CT26-model. Concluderend hebben we een PD-1/PD-L1-blokkerend peptide OPBP-1 ontdekt en geoptimaliseerd, through en vervolgens geladen in een op TMC gebaseerd hydrogel oraal toedieningssysteem, om de orale biologische beschikbaarheid van het peptidegeneesmiddel maximaal te verhogen en de tumorgroei effectief te remmen. . Deze resultaten openden een nieuw perspectief voor de ontwikkeling van orale geneesmiddelen bij immunotherapie van kanker.

Intermoleculaire interactieanalyses op SARS-CoV-2 Spike Protein Receptor Binding Area en Human Angiotensine-Changing Enzyme 2 Receptor-blocking Antibody/Peptide met behulp van fragmentmoleculaire orbitale berekening

Het spike-glycoproteïne (S-proteïne) bemiddelt SARS-CoV-2 binnenkomst through intermoleculaire interactie met humaan angiotensine-converterend enzym 2. Het receptorbindende domein (RBD) van het S-proteïne wordt als cruciaal beschouwd voor deze interactie en fungeert als het doelwit van talrijke neutraliserende antilichamen en antivirale peptiden. Deze studie gebruikte de fragment moleculaire orbitale methode om de interacties tussen de RBD en antilichamen/peptiden te analyseren en cruciale residuen te extraheren die als epitopen kunnen worden gebruikt. De interacties geëvalueerd als interfragment interactie energiewaarden tussen de RBD en 12 antilichamen / peptiden toonden een redelijk goede correlatie met de experimentele activiteit pICso ₅₀  ( R ² = 0,540). Negen residuen (T415, Ok417, Y421, F456, A475, F486, N487, N501 en Y505) werden bevestigd als cruciaal. Analyses van de ontleding van de energie van een paar interacties toonden aan dat waterstofbruggen, elektrostatische interacties en π-orbitale interacties belangrijk zijn. Onze resultaten bieden essentiële informatie voor het begrijpen van SARS-CoV-2-antilichaam / peptide-binding en kunnen een rol spelen in het toekomstige ontwerp van antilichaam / antivirale geneesmiddelen.

Alpha-bungarotoxin, CF680r
9-00003	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF640r
9-00004	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF640r
9-00004	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF488a
9-00005	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF488a
9-00005	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF568
9-00006	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF568
9-00006	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF594
9-00007	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin CF594
9-00007	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF633
9-00009	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 500uG

Alpha-bungarotoxin, CF633
9-00009	Biotium	EUR 592.80 EUR 193.20	500uG 100uG
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin
00010-1	Biotium	1MG	EUR 201.6
Description: Minimum order quantity: 1 unit of 1MG

Fluorescein-Alpha-bungarotoxin
00011	Biotium	500uG	EUR 440.4
Description: Minimum order quantity: 1 unit of 500uG

Tetramethylrhodamine-Alpha-bungarotoxin
00012	Biotium	500uG	EUR 459.6
Description: Minimum order quantity: 1 unit of 500uG

Fluorescein-alpha-bungarotoxin: (10x50ug)
00013	Biotium	10ST	EUR 500.4
Description: Minimum order quantity: 1 unit of 10ST

Tetramethylrhodamine-alpha-bungarotoxin: (10x50ug)
00014	Biotium	10ST	EUR 559.2
Description: Minimum order quantity: 1 unit of 10ST

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (500ug)
00015	Biotium	500uG	EUR 559.2
Description: Minimum order quantity: 1 unit of 500uG

Sulforhodamine 101-a-bungarotoxin (Texas Red--a-bungarotoxin): (10x50ug)
00016	Biotium	10ST	EUR 627.6
Description: Minimum order quantity: 1 unit of 10ST

Biotin-xx-a-bungarotoxin
00017	Biotium	500uG	EUR 519.6
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate
9-00018	Biotium	EUR 592.80 EUR 193.20	500uG 100ug
Description: Minimum order quantity: 1 unit of 500uG

Alpha-Bungarotoxin, CF555 conjugate
9-00018	Biotium	EUR 592.80 EUR 193.20	500uG 100ug
Description: Minimum order quantity: 1 unit of 100ug

Biotin-cAMP, diisopropylethylammonium salt:
00020	Biotium	1MG	EUR 376.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cAMP, diisopropylethylammonium salt: (20x50ug)
00020-1	Biotium	20ST	EUR 501.6
Description: Minimum order quantity: 1 unit of 20ST

Biotin-cGMP, diisopropylethylammonium salt:
00021	Biotium	1MG	EUR 412.8
Description: Minimum order quantity: 1 unit of 1MG

Biotin-cGMP, diisopropylethylammonium salt: (20x50ug)
00021-1	Biotium	20ST	EUR 537.6
Description: Minimum order quantity: 1 unit of 20ST

Cyanine 644-cAMP:
00022	Biotium	1MG	EUR 589.2
Description: Minimum order quantity: 1 unit of 1MG

Cyanine 644-cAMP: (20x50ug)
00022-1	Biotium	20ST	EUR 750
Description: Minimum order quantity: 1 unit of 20ST

Fluorescein Methotrexate, triammonium salt:
00023	Biotium	1MG	EUR 337.2
Description: Minimum order quantity: 1 unit of 1MG

Staurosporine
00025	Biotium	100uG	EUR 166.8
Description: Minimum order quantity: 1 unit of 100uG

Alpha-bungarotoxin, CF543
00026	Biotium	500uG	EUR 592.8
Description: Minimum order quantity: 1 unit of 500uG

Rhodamine phalloidin 300u
00027	Biotium	300	EUR 414
Description: Minimum order quantity: 1 unit of 300

Biotin-xx-phalloidin
00028	Biotium	100U	EUR 513.6
Description: Minimum order quantity: 1 unit of 100U

Fluorescein-phalloidin
00030	Biotium	300U	EUR 414
Description: Minimum order quantity: 1 unit of 300U

Rhodamine 110 phalloidin
00032	Biotium	300ST	EUR 414
Description: Minimum order quantity: 1 unit of 300ST

Sulforhodamine 101 (Texas-Red) Phalloidin
00033	Biotium	300EU	EUR 414
Description: Minimum order quantity: 1 unit of 300EU

Phalloidin, CF405M
00034	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF405M
00034-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

CF488A-cAMP
00036	Biotium	100ug	EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

CF640R-cAMP
00037	Biotium	100ug	EUR 206.4
Description: Minimum order quantity: 1 unit of 100ug

Phalloidin, CF555
00040	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF555
00040-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF647
00041	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF647
00041-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF488A
00042	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF488A
00042-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF543
00043	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF543
00043-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF568
00044	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF568
00044-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF594
00045	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF594
00045-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF633
00046	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF633
00046-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660R
00047	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660R
00047-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680R
00048	Biotium	300U	EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680R
00048-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF350
00049	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF350
00049-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF640R
00050	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF640R
00050-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF532
00051	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF532
00051-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF660C
00052	Biotium	300U	EUR 530.4
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF660C
00052-T	Biotium	50U	EUR 159.6
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF680
00053	Biotium	300U	EUR 559.2
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF680
00053-T	Biotium	50U	EUR 176.4
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF430
00054	Biotium	300U	EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF430
00054-T	Biotium	50U	EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Phalloidin, CF440
00055	Biotium	300U	EUR 538.8
Description: Minimum order quantity: 1 unit of 300U

Phalloidin, CF440
00055-T	Biotium	50U	EUR 166.8
Description: Minimum order quantity: 1 unit of 50U

Cholera Toxin Subunit B, CF488A conjugate
00070	Biotium	100ug	EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF568 conjugate
00071	Biotium	100ug	EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF594 conjugate
00072	Biotium	100ug	EUR 313.2
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF640R conjugate
00073	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF532 conjugate
00074	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF543 conjugate
00075	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF620R conjugate
00076	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF633 conjugate
00077	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF660R conjugate
00078	Biotium	100ug	EUR 316.8
Description: Minimum order quantity: 1 unit of 100ug

Cholera Toxin Subunit B, CF680R conjugate
00079	Biotium	100ug	EUR 338.4
Description: Minimum order quantity: 1 unit of 100ug

Human Transferrin, CF488A conjugate
00081	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF543 conjugate
00082	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF568 conjugate
00083	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF594 conjugate
00084	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF640R conjugate
00085	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF680R conjugate
00086	Biotium	1mg	EUR 178.8
Description: Minimum order quantity: 1 unit of 1mg

Human Transferrin, CF750 conjugate
00087	Biotium	1mg	EUR 186
Description: Minimum order quantity: 1 unit of 1mg

HIV-1 tat recombinant antigen
00110-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 tat recombinant antigen
00110-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 tat recombinant antigen full length 15 kDa

HIV-1 GAG P24 Recombinant Antigen
00111-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen
00111-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 nef recombinant antigen
00112-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 nef recombinant antigen
00112-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 nef recombinant antigen a.a 3 to a.a 190 of the HIV-1 nef region 20 kDa

HIV-1 env gp41 recombinant antigen
00113-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-1 env gp41 recombinant antigen
00113-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV-1 env gp41 recombinant antigen a.a 466 to a.a 753 of the HIV-1 env region 32 kDa

HIV-2 GP 36 Recombinant Antigen
00114-V-01mg	Virogen	0,1 mg	EUR 321
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HIV-2 GP 36 Recombinant Antigen
00114-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HIV -2 env gp36 recombinant antigen a.a 390 to a.a 702 of the HIV-2 env region 34 kDa

HCV core recombinant antigen
00115-V-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen
00115-V-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa

HCV core recombinant antigen, Biotin conjugate
00115-V-B-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, Biotin conjugate
00115-V-B-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Biotin conjugate.

HCV core recombinant antigen, FITC conjugate
00115-V-F-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, FITC conjugate
00115-V-F-1000ug	Virogen	1000 ug	EUR 1539
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa. Fluorescein conjugate.

HCV core recombinant antigen, Rhodamine
00115-V-R-01mg	Virogen	0,1 mg	EUR 321
Description: HCV core recombinant antigen a.a 2 to a.a 192 of HCV polyprotein 22 kDa . Rhodamine conjugate.